EXTRACELLULAR_MATRIX

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Stem cell therapy for intervertebral disc degeneration:Clinical progress with exosomes and gene vectors
《World Journal of Stem Cells》2025年第4期20-35,共16页Zhi-Peng Li Han Li Yu-Hua Ruan Peng Wang Meng-Ting Zhu Wei-Ping Fu Rui-Bo Wang Xiao-Dong Tang Qi Zhang Sen-Li Li He Yin Cheng-Jin Li Yi-Gong Tian Rui-Ning Han Yao-Bin Wang Chang-Jiang Zhang 
Supported by Henan Province Key Research and Development Program,No.231111311000;Henan Provincial Science and Technology Research Project,No.232102310411;Henan Province Medical Science and Technology Key Project,No.LHGJ20220566 and No.LHGJ20240365;Henan Province Medical Education Research Project,No.WJLX2023079;and Zhengzhou Medical and Health Technology Innovation Guidance Program,No.2024YLZDJH022.
Intervertebral disc degeneration is a leading cause of lower back pain and is characterized by pathological processes such as nucleus pulposus cell apoptosis,extracellular matrix imbalance,and annulus fibrosus rupture...
关键词：EXOSOMES Extracellular matrix repair Gene vector system Hypoxic environment Intervertebral disc degeneration Mesenchymal stem cells Regenerative medicine Stem cell therapy 
Exosomes from umbilical cord mesenchymal stromal cells promote the collagen production of fibroblasts from pelvic organ prolapse
《World Journal of Stem Cells》2024年第6期708-727,共20页Lei-Mei Xu Xin-Xin Yu Ning Zhang Yi-Song Chen 
Supported by the National Natural Science Foundation of China,No.81671439;the Science and Technology Commission of Shanghai Municipality,No.21Y11906700 and No.20Y11907300;the Medical Innovation Research Project of the Science and Technology Commission of Shanghai Municipality,No.22Y11906500。
BACKGROUND Pelvic organ prolapse(POP)involves pelvic organ herniation into the vagina due to pelvic floor tissue laxity,and vaginal structure is an essential factor.In POP,the vaginal walls exhibit abnormal collagen d...
关键词：Pelvic organ prolapse EXOSOMES FIBROBLASTS Human umbilical cord mesenchymal stromal cells Extracellular matrix Collagen I 
Deer antler stem cell niche: An interesting perspective被引量：1
《World Journal of Stem Cells》2024年第5期479-485,共7页Claudia Cavallini Elena Olivi Riccardo Tassinari Chiara Zannini Gregorio Ragazzini Martina Marcuzzi Valentina Taglioli Carlo Ventura 
In recent years,there has been considerable exploration into methods aimed at enhancing the regenerative capacity of transplanted and/or tissue-resident cells.Biomaterials,in particular,have garnered significant inter...
关键词：Extracellular matrix Antler stem cells Stem cell niche Regenerative medicine Decellularized scaffolds Cell memory 
High quality repair of osteochondral defects in rats using the extracellular matrix of antler stem cells被引量：1
《World Journal of Stem Cells》2024年第2期176-190,共15页Yu-Su Wang Wen-Hui Chu Jing-Jie Zhai Wen-Ying Wang Zhong-Mei He Quan-Min Zhao Chun-Yi Li 
National Natural Science Foundation of China,No.U20A20403;This study was conducted in accordance with the Animal Ethics Committee of the Institute of Antler Science and Product Technology,Changchun Sci-Tech University(AEC No:CKARI202309).
BACKGROUND Cartilage defects are some of the most common causes of arthritis.Cartilage lesions caused by inflammation,trauma or degenerative disease normally result in osteochondral defects.Previous studies have shown...
关键词：Osteochondral defect repair Mesenchymal stem cells Extracellular matrix DECELLULARIZATION Antler stem cells Reserve mesenchymal cells Xenogeneic 
Creating rat hepatocyte organoid as an in vitro model for drug testing
《World Journal of Stem Cells》2020年第10期1184-1195,共12页Yu-Ting He Xing-Long Zhu Sheng-Fu Li Bing-Qi Zhang Yi Li Qiong Wu Yun-Lin Zhang Yan-Yan Zhou Li Li Ya-Na Qi Ji Bao Hong Bu 
National Natural Science Foundation of China,No.81770618;Key R&D(Major Science and Technology Project)Project of Sichuan Science and Technology Department,No.2019YFS0138;Technological Innovation Project of Chengdu New Industrial Technology Research Institute,No.2018-CY02-00046-GX;and the 1.3.5 Project for Disciplines of Excellence,West China Hospital,No.ZYGD18012.
BACKGROUND Liver organoids have recently been applied as models for liver disease and drug screening,especially when combined with liver-on-a-chip technologies.Compared to hepatocyte-like cells,primary hepatocytes hav...
关键词：Organoid Primary hepatocytes Stem cells Liver therapies Extracellular matrix Drug screening 
Decellularized adipose matrix provides an inductive microenvironment for stem cells in tissue regeneration被引量：3
《World Journal of Stem Cells》2020年第7期585-603,共19页Ji-Zhong Yang Li-Hong Qiu Shao-Heng Xiong Juan-Li Dang Xiang-Ke Rong Meng-Meng Hou Kai Wang Zhou Yu Cheng-Gang Yi 
Stem cells play a key role in tissue regeneration due to their self-renewal and multidirectional differentiation,which are continuously regulated by signals from the extracellular matrix(ECM)microenvironment.Therefore...
关键词：Extracellular matrix Decellularized adipose matrix Decellularized adipose tissue Adipose-derived extracellular matrix Adipose tissue extracellular matrix Adipose matrix Stem cells Soft tissue regeneration Decellularization methods 
Amyotrophic lateral sclerosis as a protein level,non-genomic disease:Therapy with S2RM exosome released molecules被引量：2
《World Journal of Stem Cells》2017年第11期187-202,共16页Greg Maguire 
Amyotrophic lateral sclerosis(ALS) is a rapidly progressing neurodegenerative disease that leads to death. No effective treatments are currently available. Based on data from epidemiological, etiological, laboratory, ...
关键词：Amyotrophic lateral sclerosis Proteins Stem cells Extracellular matrix Exposome Heat shock protein Stem cell molecules 
Neural differentiation from pluripotent stem cells:The role of natural and synthetic extracellular matrix
《World Journal of Stem Cells》2014年第1期11-23,共13页Yan Li Meimei Liu Yuanwei Yan Shang-Tian Yang 
Supported by FSU start up fund and FSU Research Foundation GAP award;partial support from National Science Foundation,No.1342192
Neural cells differentiated from pluripotent stem cells(PSCs), including both embryonic stem cells and induced pluripotent stem cells, provide a powerful tool for drug screening, disease modeling and regenerative medi...
关键词：PLURIPOTENT stem cells Neural DIFFERENTIATION EXTRACELLULAR matrix Three-dimensional DRUG screening 
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