ISCHEMIC

作品数:605被引量:1976H指数:20
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相关领域:医药卫生更多>>
相关作者:王文孙芳玲张丽艾厚喜蒋莹更多>>
相关机构:首都医科大学北京大学上海交通大学附属第六人民医院青岛大学更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划中国博士后科学基金北京市自然科学基金更多>>
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  • 期刊=Neural Regeneration Researchx
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Neuronal autosis:the self-destructive side of autophagy involved in hypoxic-ischemic neuronal death
《Neural Regeneration Research》2025年第12期3517-3518,共2页Vanessa Ginet Pauline Depierre Julien Puyal 
supported by grants from the Swiss National Science Foundation(310030-182332 and 310030L-208141)(to JP)。
The challenge of protecting the brain resides in the unique characteristics of neurons,as they are postmitotic,long-lived,excitable,and polarized cells with long and fragile axons and dendrites.The complexity of the m...
关键词:DEATH HYPOXIC polarized 
Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage
《Neural Regeneration Research》2025年第9期2454-2463,共10页Victoria Jiménez Carretero IrisÁlvarez-Merz Jorge Hernández-Campano Sergei A.Kirov Jesús M.Hernández-Guijo 
supported by MICIU(grant number PID2021-128133NB-100/AEI/FEDER10.13039/501100011033 to JMHG);by the National Institutes of Health(grant number R01 NS083858 to SAK);the Intramural Grants Program IGPP00057(to SAK);VIC enjoys a FPU contract from the Comunidad de Madrid(PIPF-2022/SAL-GL-25948)。
The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is well-documented.Nevertheless,the role of non-excitatory amino acids in brain damage following a stroke ...
关键词:cell swelling N-methyl-D-aspartate receptor non-excitatory amino acids STROKE synaptic transmission 
The potential mechanism and clinical application value of remote ischemic conditioning in stroke被引量:1
《Neural Regeneration Research》2025年第6期1613-1627,共15页Yajun Zhu Xiaoguo Li Xingwei Lei Liuyang Tang Daochen Wen Bo Zeng Xiaofeng Zhang Zichao Huang Zongduo Guo 
supported partly by the National Natural Science Foundation of China,No.82071332;the Chongqing Natural Science Foundation Joint Fund for Innovation and Development,No.CSTB2023NSCQ-LZX0041 (both to ZG)。
Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may...
关键词:Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke NEUROINFLAMMATION neuroprotection Notch1 PI3K remote ischemic conditioning STROKE 
Next-generation regenerative therapy for ischemic stroke using peripheral blood mononuclear cells
《Neural Regeneration Research》2024年第11期2341-2342,共2页Masato Kanazawa Itaru Ninomiya Yutaka Otsu Masahiro Hatakeyama 
supported by the JSPS KAKENHI Grant-in-Aid for Scientific Research(Grant number:21K19441,22H03183)(to MK);Early-Career Scientists(Grant number:21K15185)(to IN)and(Grant number:20K16485)(to MH).
Stroke is the second leading cause of death and the third leading cause of disability worldwide after heart disease.Researchers predict that stroke deaths and permanent disabilities will increase worldwide by the year...
关键词:ISCHEMIC DEATH CEREBRAL 
Reduction of epinephrine in the lumbar spinal cord following repetitive blast-induced traumatic brain injury in rats
《Neural Regeneration Research》2024年第7期1548-1552,共5页Shigeharu Tsuda Mustafa Golam Jiamei Hou Kevin K.W.Wang Floyd J.Thompson Prodip Bose 
supported by the United States Department of Veterans Affairs Rehabilitation Research and Development Service (RR&D)[Merit Review Award numbers B3123-I/101 RX003123 and B3986-R/I01 RX003986-01A1]。
Traumatic brain inju ry-induced unfavorable outcomes in human patients have independently been associated with dysregulated levels of monoamines,especially epinephrine,although few preclinical studies have examined th...
关键词:balance blood flow cardiovascular system central nervous system EPINEPHRINE ischemic damage lumbar spinal cord muscle tone repeated blast SPASTICITY traumatic brain injury 
The presence of functional blood vessels in the ischemic core provides a therapeutic target for stroke recovery被引量:1
《Neural Regeneration Research》2023年第12期2653-2654,共2页Gary P.Morris Brad A.Sutherland 
funding support from the National Health and Medical Research Council (NHMRC;application id:2003351) of Australia (to BAS)。
Ischemic stro ke occurs when a blood vessel in the brain is occluded.In the immediate aftermath.blood flow becomes deficient in regions supplied by the blocked vessel.This leads to the development of a core region,whe...
关键词:al. THERAPEUTIC MAINTAIN 
Targeting TRPM2- and TRPM4-extrasynaptic N-methyl-D-aspartate receptor coupling in ischemic stroke被引量:1
《Neural Regeneration Research》2023年第11期2383-2384,共2页Pengyu Zong Cindy X.Li Jianlin Feng Lixia Yue 
National Institute of Health (R01-HL143750);American Heart Association (19TPA34890022) to LY。
Ischemic stroke represents a heavy burden on public health.Currently,recanalization is the only effective therapy for ischemic stroke in a small population of eligible patients.However,there is no effective adjunct me...
关键词:ASPARTATE ISCHEMIC MEDICATION 
Reperfusion after hypoxia-ischemia exacerbates brain injury with compensatory activation of the antiferroptosis system:based on a novel rat model被引量:3
《Neural Regeneration Research》2023年第10期2229-2236,共8页Tian-Lei Zhang Zhi-Wei Zhang Wei Lin Xin-Ru Lin Ke-Xin Lin Ming-Chu Fang Jiang-Hu Zhu Xiao-Ling Guo Zhen-Lang Lin 
supported by the National Natural Science Foundation of China,No.82271747(to ZLL);Medical and Health Science and Technology Program of Zhejiang Province of China,No.2023RC048(to WL)。
Hypoxic-ischemic encephalopathy,which predisposes to neonatal death and neurological sequelae,has a high morbidity,but there is still a lack of effective prevention and treatment in clinical practice.To better underst...
关键词:ferroptosis hypoxic-ischemic brain injury hypoxic-ischemic encephalopathy hypoxic-ischemic reperfusion brain injury mitochondria model proteomic analysis REPERFUSION Rice-Vannucci transmission electron microscopy 
Sex-biased autophagy as a potential mechanism mediating sex differences in ischemic stroke outcome被引量:4
《Neural Regeneration Research》2023年第1期31-37,共7页Brian Noh Louise D.McCullough Jose F.Moruno-Manchon 
supported by the American Heart Association (856061) to JFMM;by the NINDS (R01 5R01NS108779 and 5R01NS094543) to LDM
Stroke is the second leading cause of death and a major cause of disability worldwide,and biological sex is an important determining factor in stroke incidence and pathology.From childhood through adulthood,men have a...
关键词:AUTOPHAGY brain ESTROGEN gonadal hormones NEURODEGENERATION neuron stroke X-CHROMOSOME 
Homer signaling pathways as effective therapeutic targets for ischemic and traumatic brain injuries and retinal lesions被引量:4
《Neural Regeneration Research》2022年第7期1454-1461,共8页Xiu-Quan Wu Ning Su Zhou Fei Fei Fei 
supported by the National Natural Science Foundation of China,Nos.81600738(to FF),81771239(to ZF),81801300(to NS)。
Ischemic and traumatic insults to the central nervous system account for most serious acute and fatal brain injuries and are usually characterized by primary and secondary damage.Secondary damage presents the greatest...
关键词:brain injury calcium signaling cerebral ischemia dendritic spine glutamate receptor Homer scaffolding protein neuron NEUROPROTECTION retinal ganglion cell review traumatic brain injury 
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