supported by the Key Funding Project of Hunan Provincial Health Commission(A202303057091);the Nephrology Medical Development Research Fund Project(20220316ZN),China.
Objective:IgA nephropathy(IgAN)is the most common primary glomerular disease in China,but its pathogenesis remains unclear.This study aims to explore the regulatory role of the mammalian target of rapamycin(mTOR)signa...
Most of the literature focused on the proliferative forms of the lupic Glomerulonephritis. Clinicians are increasingly confronted with cases of lupic nephropathy purely mesangial (class II). The aim of our study is to...
The work was supported by the National Natural Science Foundation of China(No.81473257);the Qing Lan project,the Natural Science Foundation of Jiangsu Province(No.BK20151155);the“333”Foundation of Jiangsu Province(No.BRA2015329);the Key Natural Science Foundation of Jiangsu Higher Education Institutions of China(No.15KJA310005);the Jiangsu Overseas Research&Training Program for University Young&Middle-aged Teachers and Presidents,the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD);the Science and Technology Project of Xuzhou(No.KC18202).
Extracellular matrix(ECM)deposition following reactive oxygen species(ROS)overproduction has a key role in diabetic nephropathy(DN),thus,antioxidant therapy is considered as a promising strategy for treating DN.Here,w...
The purpose of this study was to analyze the clinical efficacy of laparoscopic total mesorectal excision for the treatment of middle and low rectal cancer.First,30 patients who received treatment in the hospital from ...
Supported by Monographic Research of Capital Traditional Chinese Medicine(No.3500-11723360)
OBJECTIVE: To investigate the effect of the clinical effective prescription of Qingre Lishi Yishen decoction(QRLS) on the activation of mesangial cells in immunoglobulin A nephropathy(IgAN) rats.METHODS: IgAN rat’s m...
Supported by Hangzhou Health Technology Project:Study of the Relationship Between Mitofusin 2 And Cyclosporine A Nephropathy(No.2018A52);National Natural Science Foundation of China:Study on Mechanism of Centella Asiatica Compound in the Treatment of Iga Nephropathy by Regulating Mesangial Cell Proliferation via Mitofusin 2(No.81373631)
OBJECTIVE:To investigate the effect of mitofusin 2 (Mfn2) and its downstream signaling pathway on glomerular mesangial cells (GMCs) proliferation in IgA nephropathy (IgAN),as well as the mechanism of action of Jixueca...
the National Natural Science Foundation of China (Nos. 81473169 and 81130060).
Mesangial proliferative glomerulonephritis (MsPGN),one of the most common glomerulonephritis pathological types,often leads to end-stage renal disease over a prolonged period.But the current treatment of MsPGN is non-...
Objective:To observe the expression of Long non-coding RNA antisense mitochondrial non-coding RNA-2 (ASncmtRNA-2) in high glucose (HG) treated human renal mesangial cells (HRMCs) and the role of ASncmtRNA-2 in oxidati...