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support from the National Natural Science Foundation of China(NSFC,No.82373798,No.52103182);Youth Interdisciplinary Special Fund of Zhongnan Hospital of Wuhan University(Grant No.ZNQNJC2023002);Young Talents Project of Hubei Province Administration of Traditional Chinese Medicine(No.ZY2023Q014).
Delays in infected wound healing are usually a result of bacterial infection and local inflammation,which imposes a significant and often underappreciated burden on patients and society.Current therapies for chronic w...
supported by Grants from National Natural Science Foundation of China(Grant No.s 31900950 and 32000944);the Project Supported by Natural Science Basic Research Plan in Shaanxi Province of China(Grant No.2024JC-YBMS-706);Collaborative Innovation Project of Zigong Medical Big Data and Artificial Intelligence Research Institute(Grant No.2023-YGY-1-02);Key Science and Technology Plan Project of Zigong(Grant No.2022ZCNKY07)。
Androgenetic alopecia(AGA),the most prevalent clinical hair loss,lacks safe and effective treatments due to downregulated angiogenic genes and insufficient vascularization in the perifollicular microenvironment of the...
supported by the National Natural Science Foundation of China (grant No.81972514,32371412 and 32071349);Zhejiang Provincial Natural Science Foundation of China under Grant No.LY23H060008 and LY24C100001;National Health Commission Scientific Research Fund&Zhejiang Provincial Medical and Health Major Science and Technology Plan Project:WKJ-ZJ-2428.
Low back pain is among the most grave public health concerns worldwide and the major clinical manifestation of intervertebral disc degeneration(IVDD).The destruction of annulus fibrosus(AF)is the primary cause of IVDD...
supported by National Key R&D Program of China(Grant number 2021YFB3800900);National Natural Science Foundation of China(Grant numbers 52073013,22122501,52221006 and 52161145410);Beijing Outstanding Young Scientist Program(No.BJJWZYJH01201910010024);approved by the Ethical Committee of Chinese Academy of Medical Sciences(CAMS).
High levels of cell-free DNA(cfDNA)induce psoriasis.Currently,the treatment of psoriasis has the disadvantages of penetration difficulty,suppression of normal immunity,and skin irritation.In this study,biguanide chito...
supported by the National Additive Manufacturing Innovative Cluster(NAMIC)POC Funding,Agency for Science,Technology and Research(A*STAR)Career Development Fund and BMRC Central Research Fund(CRF,ATR);NHG Medical Technologies&Innovations(CMTi)and National Health Innovation Centre Singapore(NHIC)Joint MedTech Grant.
Microneedles(MNs)is an emerging technology that employs needles ranging from 10 to 1000μm in height,as a minimally invasive technique for various procedures such as therapeutics,disease monitoring and diagnostics.The...
supported by the grant from the Guangdong Basic and Applied Basic Research Foundation(2020B1515130002);Collaborative Research with World-leading Research Groups from The Hong Kong Polytechnic University(P0039523);National Excellent Young Scientists Fund(Hong Kong and Macao),National Natural Science Foundation of China(No.82122002);National Natural Science Foundation of China(No.U1909218);the Science Fund for Creative Research Groups of the National Natural Science Foundation of China(No.T2121004).
Microneedle, as a novel drug delivery system, has attracted widespread attention due to its non-invasiveness, painless and simple administration, controllable drug delivery, and diverse cargo loading capacity. Althoug...
This work was funded by the National Natural Science Foundation of China(No.31860263 to Xiaolei Wang,No.82060095 to Weimin Zhou),Key Youth Project of Jiangxi Province(20202ACB216002 to Xiaolei Wang),Key Research and Development Project of Jiangxi Province(20212BBG73004 to Xiaolei Wang,20171ACG70008 to Weimin Zhou);Natural Science Foundation of Jiangxi Province(911135755018 to Weimin Zhou).
Drug-eluting balloon(DEB)angioplasty has emerged as an effective treatment for cardiovascular and cerebrovascular diseases.However,distal embolism and late lumen restenosis could be caused by drug loss during DEB hand...
A.S.would like to acknowledge the financial support from the Canadian Institutes of Health Research(CIHR)through a postdoctoral fellowship as well as the startup fund from The Pennsylvania State University;A.K.would like to acknowledge funding from the National Institutes of Health(1R01EB023052,1R01HL140618,CA257558,DK130566).We acknowledge UCLA CFAR grant 5P30 AI028697 and the UCLA AIDS Institute.The authors thank Profs.S.Li and M.Butte at UCLA for providing cryo-sectioning equipment and lab space for the blood coagulation tests,respectively.The authors also thank Prof.K.J.Lee for his advice on microneedle fabrication.
Blood loss by hemorrhaging wounds accounts for over one-third of~5 million trauma fatalities worldwide every year.If not controlled in a timely manner,exsanguination can take lives within a few minutes.Developing new ...