MICRONEEDLES

作品数:81被引量:205H指数:9
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相关领域:医药卫生更多>>
相关机构:安徽医科大学更多>>
相关期刊:《BMEMat(BioMedical Engineering Materials)》《Frontiers of Materials Science》《Advances in Chemical Engineering and Science》《Microsystems & Nanoengineering》更多>>
相关基金:国家自然科学基金高等学校学科创新引智计划中国博士后科学基金泰国研究基金更多>>
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  • 期刊=Bioactive Materialsx
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Accelerated infected wound healing by probiotic-based living microneedles with long-acting antibacterial effect被引量:2
《Bioactive Materials》2024年第8期292-304,共13页Yinli Jin Yun Lu Xue Jiang Min Wang Yaqi Yuan Yongnian Zeng Liang Guo Wei Li 
support from the National Natural Science Foundation of China(NSFC,No.82373798,No.52103182);Youth Interdisciplinary Special Fund of Zhongnan Hospital of Wuhan University(Grant No.ZNQNJC2023002);Young Talents Project of Hubei Province Administration of Traditional Chinese Medicine(No.ZY2023Q014).
Delays in infected wound healing are usually a result of bacterial infection and local inflammation,which imposes a significant and often underappreciated burden on patients and society.Current therapies for chronic w...
关键词:MICRONEEDLES Infected wound healing Probiotic Transdermal delivery LONG-ACTING 
Hydrogel forming microneedles loaded with VEGF and Ritlecitinib/polyhydroxyalkanoates nanoparticles for mini-invasive androgenetic alopecia treatment被引量:2
《Bioactive Materials》2024年第8期95-108,共14页Yan-Wen Ding Yang Li Zhi-Wei Zhang Jin-Wei Dao Dai-Xu Wei 
supported by Grants from National Natural Science Foundation of China(Grant No.s 31900950 and 32000944);the Project Supported by Natural Science Basic Research Plan in Shaanxi Province of China(Grant No.2024JC-YBMS-706);Collaborative Innovation Project of Zigong Medical Big Data and Artificial Intelligence Research Institute(Grant No.2023-YGY-1-02);Key Science and Technology Plan Project of Zigong(Grant No.2022ZCNKY07)。
Androgenetic alopecia(AGA),the most prevalent clinical hair loss,lacks safe and effective treatments due to downregulated angiogenic genes and insufficient vascularization in the perifollicular microenvironment of the...
关键词:Hydrogel forming microneedles POLYHYDROXYALKANOATES VEGF Ritlecitinib Androgenetic alopecia treatment 
Thread-structural microneedles loaded with engineered exosomes for annulus fibrosus repair by regulating mitophagy recovery and extracellular matrix homeostasis被引量:2
《Bioactive Materials》2024年第7期1-13,共13页Shaojun Hu Meng Zhu Hongyuan Xing Yucheng Xue Jun Li Zhan Wang Zhou Zhu Miaojie Fang Zilong Li Jianbin Xu Yong He Ning Zhang 
supported by the National Natural Science Foundation of China (grant No.81972514,32371412 and 32071349);Zhejiang Provincial Natural Science Foundation of China under Grant No.LY23H060008 and LY24C100001;National Health Commission Scientific Research Fund&Zhejiang Provincial Medical and Health Major Science and Technology Plan Project:WKJ-ZJ-2428.
Low back pain is among the most grave public health concerns worldwide and the major clinical manifestation of intervertebral disc degeneration(IVDD).The destruction of annulus fibrosus(AF)is the primary cause of IVDD...
关键词:Intervertebral disc degeneration MICRONEEDLE EXOSOMES Annulus fibrosus MITOPHAGY 
Biguanide chitosan microneedles with cell-free DNA scavenging ability for psoriasis therapy
《Bioactive Materials》2024年第3期497-505,共9页Zihao Liu Yu Wang Yuhan Zhang Liufu Hu Bozhi Chen Yang Li Xindong Guo Bingran Yu Fu-Jian Xu 
supported by National Key R&D Program of China(Grant number 2021YFB3800900);National Natural Science Foundation of China(Grant numbers 52073013,22122501,52221006 and 52161145410);Beijing Outstanding Young Scientist Program(No.BJJWZYJH01201910010024);approved by the Ethical Committee of Chinese Academy of Medical Sciences(CAMS).
High levels of cell-free DNA(cfDNA)induce psoriasis.Currently,the treatment of psoriasis has the disadvantages of penetration difficulty,suppression of normal immunity,and skin irritation.In this study,biguanide chito...
关键词:Biguanide chitosan cfDNA MICRONEEDLES PSORIASIS 
Design and fabrication of customizable microneedles enabled by 3D printing for biomedical applications被引量:3
《Bioactive Materials》2024年第2期222-241,共20页Jia Min Loh Yun Jie Larissa Lim Jin Ting Tay Hui Mei Cheng Hong Liang Tey Kun Liang 
supported by the National Additive Manufacturing Innovative Cluster(NAMIC)POC Funding,Agency for Science,Technology and Research(A*STAR)Career Development Fund and BMRC Central Research Fund(CRF,ATR);NHG Medical Technologies&Innovations(CMTi)and National Health Innovation Centre Singapore(NHIC)Joint MedTech Grant.
Microneedles(MNs)is an emerging technology that employs needles ranging from 10 to 1000μm in height,as a minimally invasive technique for various procedures such as therapeutics,disease monitoring and diagnostics.The...
关键词:MICRONEEDLES 3D printing Drug delivery Extraction of biological specimen BIOSENSING 
Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration被引量:13
《Bioactive Materials》2023年第9期303-326,共24页Shang Lyu Zhifei Dong Xiaoxiao Xu Ho-Pan Bei Ho-Yin Yuen Chung-Wai James Cheung Man-Sang Wong Yong He Xin Zhao 
supported by the grant from the Guangdong Basic and Applied Basic Research Foundation(2020B1515130002);Collaborative Research with World-leading Research Groups from The Hong Kong Polytechnic University(P0039523);National Excellent Young Scientists Fund(Hong Kong and Macao),National Natural Science Foundation of China(No.82122002);National Natural Science Foundation of China(No.U1909218);the Science Fund for Creative Research Groups of the National Natural Science Foundation of China(No.T2121004).
Microneedle, as a novel drug delivery system, has attracted widespread attention due to its non-invasiveness, painless and simple administration, controllable drug delivery, and diverse cargo loading capacity. Althoug...
关键词:MICRONEEDLES MICROFABRICATION Wound healing Tissue regeneration Drug delivery 
Drug-loaded balloon with built-in NIR controlled tip-separable microneedles for long-effective arteriosclerosis treatment被引量:4
《Bioactive Materials》2023年第5期526-538,共13页Li Huang Huaqiang Fang Teng Zhang Binbin Hu Shichen Liu Fanzhen Lv Zhaoxia Zeng Huijie Liu Weimin Zhou Xiaolei Wang 
This work was funded by the National Natural Science Foundation of China(No.31860263 to Xiaolei Wang,No.82060095 to Weimin Zhou),Key Youth Project of Jiangxi Province(20202ACB216002 to Xiaolei Wang),Key Research and Development Project of Jiangxi Province(20212BBG73004 to Xiaolei Wang,20171ACG70008 to Weimin Zhou);Natural Science Foundation of Jiangxi Province(911135755018 to Weimin Zhou).
Drug-eluting balloon(DEB)angioplasty has emerged as an effective treatment for cardiovascular and cerebrovascular diseases.However,distal embolism and late lumen restenosis could be caused by drug loss during DEB hand...
关键词:Photothermal responsive Drug delivery MICRONEEDLES Atherosclerosis Drug-eluting balloon 
Tissue adhesive hemostatic microneedle arrays for rapid hemorrhage treatment被引量:4
《Bioactive Materials》2023年第5期314-327,共14页Reihaneh Haghniaz Han-Jun Kim Hossein Montazerian Avijit Baidya Maryam Tavafoghi Yi Chen Yangzhi Zhu Solmaz Karamikamkar Amir Sheikhi Ali Khademhosseini 
A.S.would like to acknowledge the financial support from the Canadian Institutes of Health Research(CIHR)through a postdoctoral fellowship as well as the startup fund from The Pennsylvania State University;A.K.would like to acknowledge funding from the National Institutes of Health(1R01EB023052,1R01HL140618,CA257558,DK130566).We acknowledge UCLA CFAR grant 5P30 AI028697 and the UCLA AIDS Institute.The authors thank Profs.S.Li and M.Butte at UCLA for providing cryo-sectioning equipment and lab space for the blood coagulation tests,respectively.The authors also thank Prof.K.J.Lee for his advice on microneedle fabrication.
Blood loss by hemorrhaging wounds accounts for over one-third of~5 million trauma fatalities worldwide every year.If not controlled in a timely manner,exsanguination can take lives within a few minutes.Developing new ...
关键词:HEMOSTAT MICRONEEDLES HEMORRHAGE Bleeding Gelatin methacryloyl Silicate nanoplatelets 
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