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Effects of P2Y_1 receptor on glial fibrillary acidic protein and glial cell line-derived neurotrophic factor production of astrocytes under ischemic condition and the related signaling pathways被引量：3
《Neuroscience Bulletin》2008年第4期231-243,共13页孙景军 刘颖 叶诸榕 
the National Natural Science Foundation of China (No. 30500189)
Objective The present study aimed to explore the role of P2Y1 receptor in glial fibrillary acidic protein （GFAP） production and glial cell line-derived neurotrophic factor （GDNF） secretion of astrocytes under isch...
关键词：P2Y1 receptor GLIOSIS glial fibrillary acidic protein glial cell line-derived neurotrophic factor PI3-K/Akt/CREB JAK2/STAT3 Ras/ERK 
Regional brain susceptibility to neurodegeneration: what is the role of glial cells?被引量：4
《Neural Regeneration Research》2020年第5期838-842,共5页Andrea Beatriz Cragnolini Giorgia Lampitella Assunta Virtuoso Immacolata Viscovo Fivos Panetsos Michele Papa Giovanni Cirillo 
supported by grants from Regione Campania(L.R.N.5 Bando 2003,to MP);the Italian Minister of Research and University(PRIN 2007,to MP; PRIN 2017,to GC and MP);UNIMIB(Progetto ID 2019-ATESP-0001 and Progetto ID 2018-CONV-0056,to AV)
The main pathological feature of the neurodegenerative diseases is represented by neuronal death that represents the final step of a cascade of adverse/hostile events.Early in the neurodegenerative process,glial cells...
关键词：ASTROCYTES GLIAL cells microglia NEURODEGENERATIVE diseases neuroinflammation Parkinson's disease reactive GLIOSIS selective neuronal degeneration 
Effect of Sonic hedgehog gene-modified bone marrow mesenchymal stem cells on graft-induced retinal gliosis and retinal ganglion cells survival in diabetic mice
《International Journal of Ophthalmology(English edition)》2024年第1期34-41,共8页Tong Wang Hai-Chun Li Jin Ma Xi-Ling Yu 
Supported by the Natural Science Foundation of Guangdong Province(No.2018A0303130293,No.2023A1515012470).
AIM:To investigate the effects of Sonic hedgehog(Shh)gene-modified bone marrow mesenchymal stem cells(MSCs)on graft-induced retinal gliosis and retinal ganglion cells(RGCs)survival in diabetic mice.METHODS:Bone marrow...
关键词：mesenchymal stem cells Sonic hedgehog signaling reactive gliosis diabetic retinopathy retinal ganglion cells 
Development of a 3D matrix for modeling mammalian spinal cord injury in vitro
《Neural Regeneration Research》2016年第11期1810-1815,共6页Juan Felipe Diaz Quiroz Yuping Li Conrado Aparicio Karen Echeverri 
Spinal cord injury affects millions of people around the world, however, limited therapies are available to improve the quality of life of these patients. Spinal cord injury is usually modeled in rats and mice using c...
关键词：nerve regeneration spinal cord injury 3D scaffold in vitro models ASTROCYTES reactive gliosis neural regeneration 
Targeting tau in Alzheimer's disease:from mechanisms to clinical therapy被引量：7
《Neural Regeneration Research》2024年第7期1489-1498,共10页Jinwang Ye Huali Wan Sihua Chen Gong-Ping Liu 
supported by the National Natural Science Foundation of China,No.82101493(to JY)。
Alzheimer’s disease is the most prevalent neurodegenerative disease affecting older adults.Primary features of Alzheimer’s disease include extra cellular aggregation of amyloid-βplaques and the accumulation of neur...
关键词：ACETYLATION Alzheimer’s disease cognitive deficits GLIOSIS mitochondria damage NEUROINFLAMMATION phosphorylation synaptic impairments TAU tau immunotherapy 
ROS-removing nano-medicine for navigating inflammatory microenvironment to enhance anti-epileptic therapy被引量：2
《Acta Pharmaceutica Sinica B》2023年第3期1246-1261,共16页Zheng Zhou Keying Li Yongchao Chu Chao Li Tongyu Zhang Peixin Liu Tao Sun Chen Jiang 
support from the National Natural Science Foundation of China (81872808,82121002);Key Projects of Shanghai Science Founation (19JC1410800,China);Shanghai Municipal Science and Technology Major Project(2018SHZDZX01,China);ZJLab
As a neurological disorder in the brain,epilepsy is not only associated with abnormal synchronized discharging of neurons,but also inseparable from non-neuronal elements in the altered microenvironment.Anti-epileptic ...
关键词：EPILEPSY Polymeric micelle Reactive oxygen species Inflammation GLIOSIS NEUROPROTECTION 
Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions
《Neural Regeneration Research》2025年第7期2116-2128,共13页Yuxue Mu Ning Zhang Dongyu Wei Guoqing Yang Lilingxuan Yao Xinyue Xu Yang Li Junhui Xue Zuoming Zhang Tao Chen 
supported by the Army Laboratory Animal Foundation of China,No.SYDW[2020]22(to TC);the Shaanxi Provincial Key R&D Plan General Project of China,No.2022SF-236(to YM);the National Natural Science Foundation of China,No.82202070(to TC)。
A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain unclear.Therefore,we established an animal model of weightlessness via tail suspension to ...
关键词：glial fibrous acidic protein GLIOSIS Müller cells nerve growth factor neural differentiation neurodegeneration proteomic retinal degeneration retinal outer nuclear layer simulated weightlessness 
干细胞与视网膜变性微环境互作对干细胞命运决定的影响被引量：1
《中国科学：生命科学》2022年第7期1041-1059,共19页高世杰 莫玲玥 李明慧 邹婷 徐海伟 
国家自然科学基金(批准号:31930068,82000945)资助。
干细胞治疗视网膜变性疾病的安全性和有效性得到大量实验证据的支持,已进入临床研究阶段.然而,干细胞移植变性视网膜后,治疗效果往往在后期出现消退甚至消失.除干细胞自身的特性,植入干细胞所处的微环境是决定干细胞命运的关键因素.变...
关键词：干细胞 视网膜变性 微环境 炎症 胶质化 代谢 
Effect of Interleukin-1Beta (IL-1β) on the Cortical Neurons Survival and Neurites Outgrowth
《Advances in Bioscience and Biotechnology》2016年第1期28-37,共10页Ebtesam M. Abd-El-Basset 
Insults to the brain are known to cause a myriad of downstream effects, including the release of cytokines by astrocytes and resultant reactive gliosis. The author has examined effect of cytokine IL-1β on the surviva...
关键词：Astrocytes IL-1Β Cell Culture Neuronal Survival Cytokines GLIOSIS 
Neuroprotective effect of Paeoniae Radix Rubra on hippocampal CA1 region of mice induced by transient focal cerebral ischemia via anti-gliosis and anti-oxidant activity被引量：1
《Chinese Herbal Medicines》2019年第1期86-91,共6页Xiao-lu Zhu Bing-chun Yan Cheng Tang Guo-wei Qiu Yao Wu Jie Wang Ping Bo 
supported by Special Financial Grant from the China Postdoctoral Science Foundation(2015T80592);General Financial Grant from the China Postdoctoral Foundation(2014M561720);Key University Science Research Project of Jiangsu Province(16KJA310006);Yangzhou University Student Academic Science and Technology Innovation Project(X20170835)
Objective: Stroke is the second leading cause of death worldwide. This study aimed to investigate the neuroprotective effect of Paeoniae Radix Rubra(PRR) on ischemic stroke of mice.Methods: The focal ischemic stroke m...
关键词：CEREBRAL ISCHEMIA/REPERFUSION GLIOSIS NEUROPROTECTIVE oxidative stress Paeoniae RADIX Rubra 
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