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国家自然科学基金(81221002): 作品数：11被引量：34H指数：4; 导出分析报告; 相关作者：崔彩莲吴鎏桢卞希玲高凯王克威更多>>; 相关机构：北京大学北京大学第一医院更多>>; 相关期刊：《生物化学与生物物理进展》《中国药物依赖性杂志》《World Journal of Traditional Chinese Medicine》《Neuroscience Bulletin》更多>>; 相关主题：ELEVATEDSPTHALAMUSNEUROSTEROIDSRATS更多>>; 相关领域：医药卫生环境科学与工程生物学更多>>

神奇的“胶水”细胞: 《生物化学与生物物理进展》2022年第11期2084-2086,共3页高凯詹江山于常海; 国家自然科学基金(81471253,82171435);国家自然科学基金创新研究群体基金(81221002);中国博士后国际交流计划引进项目(YJ20210222)资助。; 胶质细胞是一类神经系统中区别于神经元的一大类细胞,其数量是神经元的10~50倍。而且在相当长的一段时间胶质细胞也被认为是神经系统中的一种“胶水”,仅起到黏结神经元和填充神经系统的作用。随着近几十年神经科学的发展,神经生物学家...; 关键词：胶质细胞生理功能神经系统疾病

ZNF804A Variation May Affect Hippocampal-Prefrontal Resting-State Functional Connectivity in Schizophrenic and Healthy Individuals被引量：4: 《Neuroscience Bulletin》2018年第3期507-516,共10页Yuyanan Zhang Hao Yan Jinmin Liao Hao Yu Sisi Jiang Qi Liu Dai Zhang Weihua Yue; supported by the National Key Research and Development Program of China (2016YFC1307000 and 2015BAI13B01);the National Natural Science Foundation of China (91432304, 81370032, 81571313 and 81221002);Capital Health Development Research (2016-2-4112);Beijing Nova Program Interdisciplinary Studies Cooperative Project (Z161100004916038); The ZNF804 A variant rs1344706 has consistently been associated with schizophrenia and plays a role in hippocampal-prefrontal functional connectivity during working memory. Whether the effect exists in the resting sta...; 关键词：SCHIZOPHRENIA ZNF804A Imaging genetics HIPPOCAMPUS Dorsolateral prefrontal cortex

Association of ABCB1 Gene Polymorphisms with Efficacy and Adverse Reaction to Risperidone or Paliperidone in Han Chinese Schizophrenic Patients被引量：4: 《Neuroscience Bulletin》2016年第6期547-549,共3页Weifeng Mi Feihu Liu Yongqiao Liu Bo Du Weidong Xiao Lingzhi Li Lan Huang Tianlan Lu Jia He Le Shi Weihua Yue Hongyan Zhang; supported by the project of Science Fund for Creative Research Groups of the National Natural Science Foundation of China(81221002);Rational Medication Application Patterns of Schizophrenia(BMU20140430) of Peking University Health Science Center; Dear editor, P-glycoprotein （P-gp, also known as ATP-binding cassette transport sub-family B member 1, ABCB1） is a potent ATP-dependent efflux pump for a wide variety of drugs. Although studies of its substrates are...; 关键词：PANSS Association of ABCB1 Gene Polymorphisms with Efficacy and Adverse Reaction to Risperidone or Paliperidone in Han Chinese Schizophrenic Patients

Elevated Neurosteroids in the Lateral Thalamus Relieve Neuropathic Pain in Rats with Spared Nerve Injury被引量：6: 《Neuroscience Bulletin》2016年第4期311-322,共12页Meng Zhang Jia Liu Meng-Meng Zhou Honghai Wu Yanning Hou Yun-Feng Li Yuxin Yin Lemin Zheng Feng-Yu Liu Ming Yi You Wan; supported by grants from the National Basic Research Development Program of China(2013CB531905,2014CB548200,and 2015CB554503);the National Natural Science Foundation of China(81230023,81221002,31200835,81571067,and 21305005);a Key Project of the Ministry of Education of China(109003);the ‘‘111’’ Project of the Ministry of Education of China(B07001); Neurosteroids are synthesized in the nervous system from cholesterol or steroidal precursors imported from peripheral sources. These compounds are important allosteric modulators of γ-aminobutyric acid A receptors （...; 关键词：NEUROSTEROIDS Translocator protein Sparednerve injury THALAMUS GABAA receptors

丙泊酚对成年大鼠的认知功能及海马CA1区糖原合成酶激酶-3β(GSK-3β)的影响被引量：5: 《中国药物依赖性杂志》2015年第6期421-426,共6页刘艳崔彩莲吴鎏桢; 国家自然科学基金委创新研究群体基金(81221002);国家重大科学研究计划(973计划)项目(2013CB531905); 目的:观察丙泊酚麻醉对成年大鼠空间认知功能及海马CA1区GSK-3β水平的影响。方法:成年SD大鼠经尾静脉注射丙泊酚麻醉6 h,苏醒后24 h接受莫里斯水迷宫(Morris Water Maze,MWM)训练,观察全身麻醉对大鼠认知功能的影响;采用免疫荧光和West...; 关键词：丙泊酚全身麻醉术后认知功能损害 GSK-3Β

Acupuncture Mechanisms: Anesthesia, Analgesia and Protection on Organ Functions被引量：3: 《World Journal of Traditional Chinese Medicine》2015年第1期59-66,共8页Jing Wang You Wan; supported by grants from The National Basic Research Program of China,Ministry of Science and Technology of China(2013CB531900);The National Natural Science Foundation of China(81230023,81221002 and 81171042);The‘‘111’’Project of The Ministry of Education of China(B07001); Acupuncture, as a healing art in traditional Chinese medicine, has been widely used to treat various diseases. In the history of acupuncture anesthesia, in the past decades, mechanisms of acupuncture analgesia has bee...; 关键词：ACUPUNCTURE acupuncture analgesia acupuncture anesthesia organ function protection IMMUNOMODULATION

Disruption of dopamine D1 receptor phosphorylation at serine 421 attenuates cocaine-induced behaviors in mice被引量：1: 《Neuroscience Bulletin》2014年第6期1025-1035,共11页Ying Zhang Ning Wang Ping Su Jie Lu Yun Wang; supported by grants from the National Natural Science Foundation of China (91332119,81161120497,30925015,30830044,31371143,30900582 and 81221002);the National Basic Research Development Program from the Ministry of Science and Technology of China (2014CB542204); Dopamine D1 receptors（D1Rs） play a key role in cocaine addiction, and multiple protein kinases such as GRKs, PKA, and PKC are involved in their phosphorylation. Recently, we reported that protein kinase D1 phosphory...; 关键词：protein kinase D1 dopamine D1 receptor PHOSPHORYLATION COCAINE ADDICTION conditioned place preference locomotor activity

Protein kinase D: a new player among the signaling proteins that regulate functions in the nervous system被引量：4: 《Neuroscience Bulletin》2014年第3期497-504,共8页Gang Li Yun Wang; supported by the National Natural Science Foundation of China (81161120497, 30925015, 30830044, 30900582, and 81221002);the National Basic Research Development Program (973 Program) of China (2014CB542204); Protein kinase D （PKD） is an evolutionarily-conserved family of protein kinases. It has structural, regulatory, and enzymatic properties quite different from the PKC family. Many stimuli induce PKD signaling, includ...; 关键词：PKD neuronal polarity pain modulation NEUROPROTECTION learning

Targeting voltage-gated Kv7/KCNQ/M-channel for therapeutic potential of neuropsychiatric disorders: 《Journal of Chinese Pharmaceutical Sciences》2014年第1期5-15,共11页卞希玲王克威; National Natural Science Foundation of China(Grant No.81000552,30970919 and 81221002);the Ministry of Science and Technology of China(Grant No.2013CB531300); M-type potassium current （IM） was initially isolated from sympathetic neurons in 1980 and named as it was inhibited by muscarine. In 1998, the molecular identity of M-current was revealed to be heterotetramers of KC...; 关键词：Kv7.2 RETIGABINE XE991 EPILEPSY PAIN

Crystal structure of the N-terminal ankyrin repeat domain of TRPV3 reveals unique conformation of fi nger 3 loop critical for channel function被引量：3: 《Protein & Cell》2013年第12期942-950,共9页Di-Jing Shi Sheng Ye Xu Cao Rongguang Zhang KeWei Wang; This work was supported by research grants from the National Natural Science Foundation of China to KWW(Grant Nos.30970919 and 81221002);the National Basic Research Program(973 Program)to KWW(No.2013CB531300).; In all six members of TRPV channel subfamily,there is an ankyrin repeat domain(ARD)in their intracellular N-termini.Ankyrin(ANK)repeat,a common motif with typi-cally 33 residues in each repeat,is primarily involved in...; 关键词：TRPV3 ARD KERATINOCYTE 2-APB skin

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