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国家自然科学基金(20321202): 作品数：12被引量：4H指数：1; 导出分析报告; 相关作者：伍贻康吴建忠甄志彬张奕华更多>>; 相关机构：中国药科大学中国科学院更多>>; 相关期刊：《化学学报》《Chinese Journal of Chemistry》更多>>; 相关主题：PEROXIDEANTIMALARIALARTEMISININCLEAVAGESYNTHESIS更多>>; 相关领域：理学医药卫生化学工程更多>>

外消旋木榄醇甲的简捷合成被引量：1: 《化学学报》2008年第19期2138-2140,共3页吴建忠甄志彬张奕华伍贻康; 国家自然科学基金(Nos.20372075,20321202,20672129,20621062,20772143);中国科学院知识创新工程(No.KJCX2.YW.H08)资助项目; 报道了天然产物木榄醇甲的一种高效合成方法.目标分子结构中的饱和碳链部分以廉价的化工原料4-羰基戊酸(国内俗称"左旋糖酸"或"果糖酸")为起始原料合成.经Wittig反应与间甲氧基苯甲醛相连接后,对所形成的碳-碳双键进行环氧化并在苄位进...; 关键词：FRIEDEL-CRAFTS反应桥环天然产物全合成缩酮

Synthesis of a 1,2,7,8-Tetraoxa-spiro[5.5]undecane被引量：1: 《Chinese Journal of Chemistry》2007年第9期1304-1308,共5页张琦李云伍贻康; Project supported by the National Natural Science Foundation 0f China （Nos. 20025207, 20272071, 20372075, 20321202, 20672129, and 20621062）, and the Chinese Academy of Sciences （Nos. NKGCX2-SW-209 and KJCX2.YW.H08）.; Synthesis of a new spiro organic peroxide is described. The peroxy bonds were incorporated into the substrate framework via an acid-catalyzed ketal exchange reaction using hydrogen peroxide as the source of peroxy lin...; 关键词：PEROXIDE ANTIMALARIAL ARTEMISININ hydrogen peroxide spiro compound

Synthesis of 15-Demethyl Brefeldin A and Its 7-epi Isomer: 《Chinese Journal of Chemistry》2007年第6期802-807,共6页沈鑫杨永青胡祺黄嘉慧高剑伍贻康; Project supported by the National Natural Science Foundation of China （Nos. 20025207, 20272071, 20372075, 20321202, 20672129, 20621062）, and the Chinese Academy of Sciences （Nos. NKGCX2-SW-209, KJCX2.YW.H08）.; Synthesis of 15-demethyl brefeldin A and its 7-epimer is detailed. X-ray crystallographic structure for 15-demethyl brefeldin A is also disclosed.; 关键词：ANTIBIOTICS asymmetric synthesis ANALOGUE LACTONE

Solvent-switchable Acetalization by Yb（OTf）3-Catalyzed Procedures被引量：2: 《Chinese Journal of Chemistry》2007年第1期90-94,共5页李纲琴单伟光苏为科姚祝军; Project supported by the National Natural Science Foundation of China （Nos. 20425205, 20321202） and the Shanghai Municipal Commission of Science and Technology （Nos. 04DZ 14901, 06QH 14016）.; O,O＇Diethyl acetals were prepared in high yields under mild conditions via the reaction of triethyl orthoformate with aldehydes and ketones in absolute ethanol in the presence of as low as 0.1 tool% of Yb（OTf）3. Us...; 关键词：ACETALIZATION Yb（OTf）3 CARBONYL protection DEPROTECTION

An Efficient Synthesis of Selective Human NR2A Antagonist NVP-AAM077: 《Chinese Journal of Chemistry》2006年第12期1784-1787,共4页李纲琴苏为科姚祝军; Project supported by the Natural Science Foundation of China （Nos. 20425205, 20321202）, Chinese Academy of Sciences （No. KGCX2-SW-209） and Shanghai Municipal Commission of Science and Technology （No. 04DZ14901）.; A short and efficient synthesis of the selective human N-methyl-D-aspartate （NMDA） receptor 2A （NR2A） antagonist NVP-AAM077 is described. The target was achieved in 8 steps and in 54% overall yield from the commer...; 关键词：NMDA receptor 2A ANTAGONIST NVP-AAM077 SYNTHESIS amino phosphonic acid

Synthesis of 1,2-Dioxane Type Antimalarial Peroxides: 《Chinese Journal of Chemistry》2006年第9期1180-1189,共10页刘鹤华张琦金红霞沈鑫伍贻康; Project supported by the National Natural Science Foundation of China （Nos. 20025207. 20272071, 20372075 and 20321202） and the Chinese Academy of Sciences （No. KGCX2-SW-209）. Dedicated to Professor Xikui Jiang on the occasion of his 80th birthday.; Synthesis of five simple analogues of peroxyplakoric acid by using Kobayashi＇s method to construct the key 1,2-dioxane core is detailed.; 关键词：PEROXIDE CYCLIZATION hemiketal ANTIMALARIAL

Synthesis of a Nitro Analogue of Plakoric Acid: 《Chinese Journal of Chemistry》2006年第9期1190-1195,共6页张琦金红霞刘鹤华伍贻康; Project supported by the National Natural Science Foundation of China （Nos. 20025207, 20272071, 20372075, 20321202） and the Chinese Academy of Sciences （No. KGCX2-SW-209）. Dedicated to Professor Xikui Jiang on the occasion of his 80th birthday.; Synthesis of a nitro analogue of plakoric acid is presented. The peroxy bond was incorporated into the substrate structure through a boron trifluoride etherate catalyzed methoxy-hydroperoxy group partial exchange reac...; 关键词：PEROXIDE CYCLIZATION hemiketal EXCHANGE ANTIMALARIAL

Synthesis and in vino Antimalarial Activity of Several Simple Analogues of Peroxyplakoric Acid: 《Chinese Journal of Chemistry》2005年第11期1469-1473,共5页LIU, He-Hua JIN, Hong-Xia ZHANG, Qi WU, Yi-Kang KIM, Hye-Sook WATAYA, Yusuke; Project supported by the National Natural Science Foundation of China （Nos. 20025207, 20272071, 20372075, 20321202）, the Chinese Academy ot Sciences （“Knowledge Innovation”project, KGCX2-SW-209）, and the Major State Basic Research Development Program （No. G2000077502） of China.; Several simple analogues of peroxyplakoric acid were synthesized by using Kobayashi＇s method to construct the key 1,2-dioxane core and tested in vitro for antimalarial activity. The scope and limitation of the method...; 关键词：PEROXIDES SPIROKETALS CYCLIZATIONS hemiketals

Conversion of N-Acyl-4-phenyl/benzyl-oxazolidine-2-thiones into Thiol Esters in the Presence of EtSH-K2CO3: 《Chinese Journal of Chemistry》2005年第11期1561-1563,共3页HU, Qi SUN, Ya-Ping WU, Yi-Kang; Project supported by the National Natural Science Foundation of China （Nos. 20025207, 20272071, 20372075 and 20321202）, the Kn6wledge Innovation Project of the Chinese Academy of Sciences （No. KGCX2-SW-209）, and the Major State Basic Research Development Program （No. G2000077502）.; N-Acyl-β-hydroxy-4-phenyl-oxazolidinethiones could be rapidly converted into their ethyl thiol esters in high yields by treatment with EtSH at 0 ℃ in CH3CN or 9 ： 1 （V ： V） THF-H2O in the presence of a catalytic...; 关键词：chiral auxiliary cleavage thiol ester ALDOL

An Efficient Enantioselective Synthesis of Blastmycinone: 《Chinese Journal of Chemistry》2005年第11期1519-1522,共4页YANG, Yong-Qing wu, Yi-Kang; Project supported by the National Natural Science Foundation of China （Nos. 20025207, 20272071, 20372075, 20321202）, the Chinese Academy of Sciences （Knowledge Innovation Project, No. KGCX2-SW-209）, and the Major State Basic Research Development Program （No. G2000077502）.; Blastmycinone, a degradation product of the antibiotic antimycin A, was synthesized with a TiCl4-mediated asymmetric aldolization as the key step. Some unexpected yet interesting chemistry was also observed.; 关键词：LACTONE asymmetric synthesis ALDOL ACYLATION chiral auxiliary

国家自然科学基金(20321202)