《Animal Models and Experimental Medicine》

作品数：478被引量：702H指数：10
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《Animal Models and Experimental Medicine》
主办单位：中国实验动物学会;中国医学科学院医学实验动物研究所
最新期次：2025年4期更多>>
发文主题：ANIMAL_MODELANIMALMICERATMOUSE更多>>
发文领域：医药卫生生物学农业科学历史地理更多>>
发文基金：国家自然科学基金北京市自然科学基金中国博士后科学基金上海市自然科学基金更多>>
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Animal models of human herpesvirus infection
《Animal Models and Experimental Medicine》2025年第4期615-628,共14页Ziqing Jia Dong Zhang Lin Zhu Jing Xue 
National Natural Science Foundation of China,Grant/Award Number:82222041 and 82241068;CAMS Innovation Fund for Medical Sciences,Grant/Award Number:2021-I2M-1-037 and 2023-I2M-2-001;National Key Research and Development Project of China,Grant/Award Number:2023YFC2309000;Beijing Natural Science Foundation,Grant/Award Number:Z220018。
Human herpesvirus,a specific group within the herpesvirus family,is responsible for a variety of human diseases.These viruses can infect humans and other vertebrates,primarily targeting the skin,mucous membranes,and n...
关键词：animal models EBV HSV human herpesvirus KSHV VZV 
The protective effects of melatonin against electromagnetic waves of cell phones in animal models:A systematic review
《Animal Models and Experimental Medicine》2025年第4期629-637,共9页Mohammad Amiri Habibolah Khazaie Masoud Mohammadi 
Deputy for Research and Technology,Kermanshah University of Medical Sciences,Grant/Award Number:4030031。
Background:Due to the widespread use of cell phone devices today,numerous re-search studies have focused on the adverse effects of electromagnetic radiation on human neuropsychological and reproductive systems.In most...
关键词：animal model cell phone radiation MELATONIN 
FOXK1 promotes hormonally responsive breast carcinogenesis by suppressing apoptosis
《Animal Models and Experimental Medicine》2025年第4期638-648,共11页Minghui Zhao Tingyao Ma Zhaohan Zhang Yu Wang Xilin Wang Wenjuan Wang Xiaohong Chen Ran Gao Lin Shan 
Beijing High-Level Innovation and Entrepreneurship Talent Support Plan,Grant/Award Number:G04070024;National Natural Science Foundation of China,Grant/Award Number:82073122。
Background:Globally,breast cancer constitutes the predominant malignancy in women.Abnormal regulation of epigenetic factors plays a key role in the development of tumors.Anti-apoptosis is a characteristic of tumor cel...
关键词：APOPTOSIS estrogen receptor-positive breast cancer FOXK1 transcription repression 
RNA-seq analysis of mitochondria-related genes regulated by AMPK in the human trophoblast cell line BeWo
《Animal Models and Experimental Medicine》2025年第4期649-661,共13页Bin Wu Albert Gao Bin He Yun Chen Xiangfeng Kong Fayuan Wen Haijun Gao 
Dean's Office Howard University College of Medicine,Grant/Award Number:Bridge Fund/Pilot Study Award;National Center on Minority Health and Health Disparities,Grant/Award Number:RCMI/IDC Award U54MD007597;National Institute of Child Health and Human Development,Grant/Award Number:R03HD095417 and R16HD116702。
Background:How AMP activated protein kinase(AMPK)signaling regulates mito-chondrial functions and mitophagy in human trophoblast cells remains unclear.This study was designed to investigate potential players mediating...
关键词：AMPK ATP production gene expression MITOCHONDRIA RNA-SEQ TROPHOBLAST 
The miR-6779/XIAP axis alleviates IL-1β-induced chondrocyte senescence and extracellular matrix loss in osteoarthritis
《Animal Models and Experimental Medicine》2025年第4期662-673,共12页Zongchao Li Aonan Dai Xiaoxiang Fang Kexing Tang Kun Chen Peng Gao Jingyue Su Xin Chen Shengwu Yang Zhenhan Deng Liangjun Li 
Natural Science Foundation of Changsha city,China,Grant/Award Number:kq2403166;Hunan Provincial Clinical Medical Technology Innovation Guiding Project,Grant/Award Number:2020SK53307;Basic Public Welfare Research projects of Wenzhou Science and Technology Bureau,Grant/Award Number:Y20240087;Natural Science Foundation of Hunan Province,Grant/Award Number:2020JJ8043;Start-up Funding for Talented Scientific Research of the First Affiliated Hospital of Wenzhou Medical University,Grant/Award Number:2023QD026;Key Project of Hunan Provincial Health Commission,Grant/Award Number:20201902 and C2019133;National Natural Science Foundation of China,Grant/Award Number:82472495。
Background:Osteoarthritis(OA)is a long-term degenerative joint disease worsen-ing over time.Aging and chondrocyte senescence contribute to OA progression.MicroRNAs have been confirmed to regulate different cellular pr...
关键词：CHONDROCYTE miR-6779 OSTEOARTHRITIS SENESCENCE X-linked inhibitor of apoptosis protein 
A study on the variation of cytokine and electrolyte levels in rhesus macaques,cynomolgus monkeys,and Assamese macaques
《Animal Models and Experimental Medicine》2025年第4期674-684,共11页Suqin Duan Jinghan Hou Yanyan Li Wenting Sun Mingxue Li Lixiong Chen Hongjie Xu Weihua Jin Quan Liu Jie Tang Zijun Deng Fengmei Yang Zhanlong He 
National Resources Center for Non Human Primates;National Key R&D Project of China,Grant/Award Number:2021YFF0702804。
Background:Non-human primates(NPHs),such as rhesus macaques,cynomol-gus monkeys,and Assamese macaques,play a crucial role in biomedical research.However,baseline cytokine and electrolyte data for these three species,p...
关键词：Assamese macaque cynomolgus monkey CYTOKINES electrolytes rhesus macaque 
Processing-induced reduction in dianthrones content and toxicity of Polygonum multiflorum:Insights from ultra-high performance liquid chromatography triple quadrupole mass spectrometry analysis and toxicological assessment
《Animal Models and Experimental Medicine》2025年第4期685-695,共11页Wan-Fang Li Ying Wang Cai-Xia Qiu Jie Li Jie Bao Jian-Bo Yang Hong-Tao Jin 
National Natural Science Foundation of China,Grant/Award Number:81973476;Chinese Society of Toxicology,Grant/Award Number:CST2021CT101。
Background:Polygonum multiflorum-induced liver injury(PM-DILI)has significantly hindered its clinical application and development.Methods:This study investigates the variation in content and toxicity of dian-thrones,t...
关键词：dianthrones HEPATOTOXICITY Polygonum multiflorum Thunb. ultra-high performance liquid chromatography triple quadrupole mass spectrometry(UHPLC-QQQ-MS/MS) zebrafish embryos 
Experimental study of a novel mouse model of tibial shaft fracture combined with blunt chest trauma
《Animal Models and Experimental Medicine》2025年第4期696-706,共11页Bing Zhang Tingting Fu Yi Han Gongke Li Xianyao Wan Yong Li 
This study was supported by Development Project of Key Laboratory of Big Data Analysis and Knowledge Service of Science and Technology Innovation Platform of Yangzhou-Yangzhou University Cooperation,Grant/Award Number:YBK202204;Jiangsu Province 333 High-level Talent.Training Project,Grant/Award Number:BRA2020176。
Backgroud:Thoracic Trauma and Limb Fractures Are the Two most Common Injuries in Multiple Trauma.However,there Is Still a Lack of Mouse Models of Trauma Combining Tibial Shaft Fracture(TSF)and Thoracic Trauma.In this ...
关键词：animal model CYTOKINES MICROIMAGING multiple trauma pulmonary contusion 
Comparison of the pathogenicity and neutrophil and monocyte response between SARS-CoV-2 prototype and Omicron BA.1 in a lethal mouse model
《Animal Models and Experimental Medicine》2025年第4期707-717,共11页Na Rong Jing Wu Binbin Zhao Wanjun Peng Hekai Yang Gengxin Zhang Dangting Ruan Xiaohui Wei Jiangning Liu 
supported by Beijing Natural Science Foundation(Grant No.Z210014);National Natural Science Foundation of China(Grant No.32070543);National Key Research and Development Project of China(Grant No.2022YFC2303404);CAMS Innovation Fund for Medical Sciences(CIFMS)(Grant No.2022-12M-CoV19-002)
Background:SARS-CoV-2,first identified in late 2019,has given rise to numerous variants of concern(VOCs),posing a significant threat to human health.The emer-gence of Omicron BA.1.1 towards the end of 2021 led to a pa...
关键词：animal model SARS-CoV-2 Omicron BA.1 MONOCYTE NEUTROPHIL 
Editor-in-Chief: Chuan Qin
《Animal Models and Experimental Medicine》2025年第4期I0001-I0001,共1页
Chuan Qin,MD,PhD,is the President of the Chinese Association for Laboratory Animal Sciences(CALAS),and the permanent professor of Chinese Academy of Medical Sciences(CAMS)&Peking Union Medical College(PUMC).Moreover,s...
关键词：editor chief permanent professor Chuan Qin Chinese Academy Medical Sciences MD animal sciences calas PHD PRESIDENT 
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