《Cellular & Molecular Immunology》

作品数：2337被引量：11798H指数：39
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《Cellular & Molecular Immunology》
主办单位：中国免疫学会
最新期次：2024年12期更多>>
发文主题：IMMUNITYINFLAMMATIONIMMUNOTHERAPYSARS-COVMACROPHAGES更多>>
发文领域：医药卫生生物学农业科学文化科学更多>>
发文基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>
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No more LAGging behind PD-1:uncovering the unique role of LAG-3 in T-cell exhaustion
《Cellular & Molecular Immunology》2024年第12期1351-1353,共3页Yunju Jo Hyung-seung Jin Yoon Park 
supported by an intramural grant from KIST to YP,as well as grants from the National Research Foundation of Korea(NRF)funded by the Korean government(MSIT)(NRF-2020M3A9G7103935 and RS-2024-00338729 to HJ and RS-2024-00337093 to YP).
Exhausted T(Tex)cells are a distinct subset of T cells that arise in response to prolonged antigen exposure during chronic infections or cancer.Although Tex cells exhibit reduced functionality,they still retain some p...
关键词：IMMUNITY protective thereby 
Immunotherapy for glioblastoma:current state,challenges,and future perspectives
《Cellular & Molecular Immunology》2024年第12期1354-1375,共22页Yang Liu Fei Zhou Heba Ali Justin D.Lathia Peiwen Chen 
supported in part by National Institutes of Health(NIH)R01 NS127824(PC),NIH R01 NS124594(PC),NIH P01 CA245705(JDL),R35 NS127083(JDL);the Department of Defense(DoD)Career Development Award W81XWH-21-1-0380(P.C.),as well as the Lerner Research Institute and Case Comprehensive Cancer Center.
Glioblastoma(GBM)is an aggressive and lethal type of brain tumor in human adults.The standard of care offers minimal clinical benefit,and most GBM patients experience tumor recurrence after treatment.In recent years,s...
关键词：GLIOBLASTOMA Immune checkpoint inhibitors(ICIs) Adoptive T-cell therapies Tumor vaccines Oncolytic viral therapies Immunotherapy combination 
Targeting of TAMs:can we be more clever than cancer cells?
《Cellular & Molecular Immunology》2024年第12期1376-1409,共34页Julia Kzhyshkowska Jiaxin Shen and Irina Larionova 
supported by the China Scholarship Council(No.202306320511);by the BSMU Strategic Academic Leadership Program PRIORITY-2030.
With increasing incidence and geography,cancer is one of the leading causes of death,reduced quality of life and disability worldwide.Principal progress in the development of new anticancer therapies,in improving the ...
关键词：EPIGENETIC Metabolism Scavenger receptor CYTOKINE Growth factor Angiogenesis Immunotherapy 
CD30 influences germinal center B-cell dynamics and the expansion of IgG1-switched B cells
《Cellular & Molecular Immunology》2024年第12期1410-1425,共16页Yan Wang Ursula Rambold Petra Fiedler Tea Babushku Claas L.Tapken Kai P.Hoefig Thomas P.Hofer Heiko Adler AliÖnder Yildirim Lothar J.Strobl Ursula Zimber-Strobl 
supported by the Deutsche Krebshilfe,Nr.70113859 to U.Z.-S.and H.A.,the Wilhelm-Sander-Stiftung Nr.2022.128.1 to A.Ö.Y and U.Z.-S.and the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under award number R01AI170965。
Initially,identified as a Hodgkin lymphoma marker,CD30 was subsequently detected on a subset of human B cells within and around germinal centers(GCs).While CD30 expression is typically restricted to a few B cells,expa...
关键词：B lymphocytes Germinal center reaction CD30 Conditional mice CD30L Senescence associated T cells(SAT cells) 
Kynurenine-AhR reduces T-cell infiltration and induces a delayed T-cell immune response by suppressing the STAT1-CXCL9/CXCL10 axis in tuberculosis
《Cellular & Molecular Immunology》2024年第12期1426-1440,共15页Xin Liu Mengjie Yang Ping Xu Mingwei Du Shanshan Li Jin Shi Qiang Li Jinfeng Yuan Yu Pang 
supported by the National Key Research and Development Program of China(2022YFC2302901);the National Natural Science Foundation of China(82272346,82072243,82202530);the Sponsored by Beijing Nova Program(20220484169,20230484295);the Provincial Key Research and Development Program of Jiangsu in Social Development(BE2023718).
Tuberculosis,caused by Mycobacterium tuberculosis(Mtb),is a critical global health issue that is complicated by the ability of the pathogen to delay the host’s T-cell immune response.This delay in T-cell recruitment ...
关键词：Mycobacterium tuberculosis Tryptophan metabolism IDO1 IMMUNOSUPPRESSION CHEMOKINES 
Ubiquitin regulatory X(UBX)domain-containing protein 6 is essential for autophagy induction and inflammation control in macrophages
《Cellular & Molecular Immunology》2024年第12期1441-1458,共18页Young Jae Kim Sung-Gwon Lee So Young Park Sang Min Jeon Soo In Kim Kyung Tae Kim Taylor Roh Sang-Hee Lee Min Joung Lee Jinyoung Lee Hyeon Ji Kim So Eui Lee Jin Kyung Kim Jun Young Heo In Soo Kim Chungoo Park Seungwha Paik Eun-Kyeong Jo 
supported by the National Research Foundation of Korea(NRF)grants funded by the Korea government(MSIT)(RS-2023-00255021,RS-2023-00227274,and RS-2024-00406568).
Ubiquitin regulatory X(UBX)domain-containing protein 6(UBXN6)is an essential cofactor for the activity of the valosin-containing protein p97,an adenosine triphosphatase associated with diverse cellular activities.None...
关键词：UBXN6 SEPSIS INFLAMMATION AUTOPHAGY Immunosuppressi 
Age-associated imbalance in immune cell regeneration varies across individuals and arises from a distinct subset of stem cells
《Cellular & Molecular Immunology》2024年第12期1459-1473,共15页Anna Nogalska Jiya Eerdeng Samir Akre Mary Vergel-Rodriguez Yeachan Lee Charles Bramlett Adnan Y.Chowdhury Bowen Wang Colin G.Cess Stacey D.Finley Rong Lu 
supported by NIH-R00-HL113104,R01HL138225,and R35HL150826;R.Lu is a scholar of the Leukemia&Lymphoma Society(LLS-1370-20);The project described was supported in part by award number P30CA014089 from the National Cancer Institute;CB is supported by National Institutes of Health grant 1F31HL149278-01A1;JE is supported by the California Institute for Regenerative Medicine grant EDUC4-12756.
The age-associated decline in immunity manifests as imbalanced adaptive and innate immune cells,which originate from the aging of the stem cells that sustain their regeneration.Aging variation across individuals is we...
关键词：aging clonal tracking hematopoietic stem cells lineage bias MYELOPOIESIS 
Glut3 promotes cellular O-GlcNAcylation as a distinctive tumorsupportive feature in Treg cells
《Cellular & Molecular Immunology》2024年第12期1474-1490,共17页Amit Sharma Garima Sharma Zhen Gao Ke Li Mutong Li Menglin Wu Chan Johng Kim Yingjia Chen Anupam Gautam Hong Bae Choi Jin Kim Jung-Myun Kwak Sin Man Lam Guanghou Shui Sandip Paul Yongqiang Feng Keunsoo Kang Sin-Hyeog Im Dipayan Rudra 
YC was financially supported by the Dissertation Completion Award of the University of Georgia and American Lebanese Syrian Associated Charities(ALSAC)at St.Jude Children’s Research Hospital;AG acknowledges support by the High Performance and Cloud Computing Group at the Zentrum für Datenverarbeitung of the University of Tübingen,the state of Baden-Württemberg through bwHPC and the German Research Foundation(DFG)through grant no INST 37/935-1 FUGG,and the de.NBI Cloud within the German Network for Bioinformatics Infrastructure(de.NBI)and ELIXIR-DE(Forschungszentrum Jülich and W-de.NBI-001,W-de.NBI-004,W-de.NBI-008,W-de.NBI-010,W-de.NBI-013,W-de.NBI-014,W-de.NBI-016,W-de.NBI-022)for supporting the computational analysis carried out in this work.AS was supported by BrainKorea21 Plus scholarship from the National Research Foundation of Korea(NRF);This research,in part,was supported by the Basic Science Research Program(grant#4.24643.01)funded by the Ministry of Education,Korea,and NRF grants#RS-2023-00260454(AS)and RS-2024-00345575(SHI)funded by the Korea Ministry of Science and ICT(MSIT);DR is recipient of National Natural Science Foundation of China grant#32470980.
Regulatory T cells(Tregs)establish dominant immune tolerance but obstruct tumor immune surveillance,warranting context-specific mechanistic insights into the functions of tumor-infiltrating Tregs(TIL-Tregs).We show th...
关键词：Regulatory T cells TREG GLUT3 O-GLCNACYLATION Treg metabolism 
Specific ECM degradation potentiates the antitumor activity of CAR-T cells in solid tumors
《Cellular & Molecular Immunology》2024年第12期1491-1504,共14页Rui Zheng Kuo Shen Sixin Liang Yanhong Lyu Siyan Zhang Hao Dong Yuanfeng Li Yujie Han Xiaojuan Zhao Yiting Zhang Pengju Wang Ruotong Meng Shukun Bai Jianxun Yang Guofang Lu Jia Li Angang Yang Rui Zhang Bo Yan 
supported by a grant from the National Natural Science Foundation of China(No.81972870);the Independent Research Topic of State Key Laboratory of Cancer Biology of Fourth Military Medical University(CBSKL2022ZZ20);Tangdu Hospital-key research project(2022TDGS007).
Although major progress has been made in the use of chimeric antigen receptor(CAR)-T-cell therapy for hematological malignancies,this method is ineffective against solid tumors largely because of the limited infiltrat...
关键词：CAR-T cells synNotch receptor ECM-degrading enzymes INFILTRATION 
Targeting GSDME-mediated macrophage polarization for enhanced antitumor immunity in hepatocellular carcinoma
《Cellular & Molecular Immunology》2024年第12期1505-1521,共17页Shiping Chen Peiling Zhang Guiqi Zhu Biao Wang Jialiang Cai Lina Song Jinglei Wan Yi Yang Junxian Du Yufan Cai Jian Zhou Jia Fan Zhi Dai 
supported by the National Natural Science Foundation of China(No.82372946,No.82072670,and No.81871916);the Leading Project of the Science and Technology Committee of Shanghai Municipality(No.21Y21900100);the Project of Shanghai Municipal Health Commission(No.202140269).
Despite the notable efficacy of anti-PD1 therapy in the management of hepatocellular carcinoma(HCC)patients,resistance in most individuals necessitates additional investigation.For this study,we collected tumor tissue...
关键词：GSDME IMMUNOTHERAPY MACROPHAGES Hepatocellular carcinomas 
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