supported by grants from the STI2030-Major Projects(2021ZD0204000);the Key Strategic Science and Technology Cooperation Project(2023YFE0206800);the Ministry of Science and Technology of China,the National Natural Science Foundation of China(31820103005,32170976,32100791,and 81971874),Zhejiang Province Natural Science Foundation of China(LZ24C090003 and LY21C090003);the Peak Discipline Cultivation Program of Zhejiang University School of Basic Medicine.
Dear Editor,In recent years,there has been an increasing focus on the non-motor functions of the cerebellum[1,2].Clinical observations have demonstrated that individuals with cerebellar damage exhibit affective insens...
supported by the National Nature Science Foundation of China(82171173,82071177,91732302,and 82201321);the Shanghai Brain-Intelligence Project of Science and Technology Commission of Shanghai Municipality(16JC1420501 and 22YF1422500);Strategic Priority Research Program of the Chinese Academy of Sciences(XDBS01060200)and the Shanghai Municipal Science and Technology Major Project(2018SHZDZX05);Shanghai Ninth People’s Hospital Grant(JYZP001).
Dear Editor,The brain has complex molecular and cellular compositions.Current knowledge about the molecular taxonomy of the brain is mainly based on rodent studies.Although they share common ancestors,primates and rod...
supported by grants from the National Natural Science Foundation of China(82090033,82288101,U20A6005,32200801,and 32200967);China Postdoctoral Science Foundation(2021M700851,2023T160117,and 2023M740708).
The nucleus accumbens(NAc)plays an important role in various emotional and motivational behaviors that rely on heightened wakefulness.However,the neural mechanisms underlying the relationship between arousal and emoti...
supported by grants from the National Natural Science Foundation of China (81920108016 and 32230041);the Priority Academic Program Development of Jiangsu Higher Education Institutions of China;the Chinese Red Cross Foundation National Brain Nutrition Research Fund.
Irritable bowel syndrome(IBS)is a common functional bowel disorder characterized by abdominal pain and visceral hypersensitivity.Reducing visceral hypersensitivity is the key to effectively relieving abdominal pain in...
supported by the National Natural Science Foundation of China,2021 Original Exploration Program recommended by experts(82150007);the Natural Science Foundation of Jiangsu Province(BK20190987);and the Chinese Postdoctoral Science Foundation(2018M642328).
We previously identified a unique nucleus,the cerebrospinal fluid(CSF)-contacting nucleus.This study aims to understand its gene architecture and preliminarily suggest its functions.The results showed that there were ...
supported by the National Natural Science Foundation of China(82001424,82171176);the Key Program of the Natural Science Foundation of Zhejiang,China(LZ19H090003).
The incidence rate of anxiety and depression is significantly higher in patients with inflammatory bowel diseases(IBD)than in the general population.The mechanisms underlying dextran sulfate sodium(DSS)-induced depres...
This Highlight was supported by the National Natural Science Foundation of China(31871202,32170984);the Department of Science and Technology of Shandong Province(ZR2019MC057);Excellent Innovative Team of Shandong Province(2020KJK007);Taishan Scholars Construction Project of Shandong Province,China.
Parkinson's disease(PD)is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta(SNpc),accompanied by severe locomotor deficits[1].Deep brain stimulation(DBS)mainly targeting the subth...
supported by the Key-Area Research and Development Program of Guangdong Province(2019B030335001 and 2018B030334001);the Natural Science Foundation of China(31871070 and 82090031);the Key R&D Program of Zhejiang Province(2020C03009);Funda-mental Research Funds for the Central Universities 2021FZZX001-37,the Non-Profit Central Research Institute Fund of the Chinese Academy of Medical Sciences(2019PT310023);and the CAMS Innovation Fund for Medical Sciences(2019-12M-5-057).
Licking behavior is important for water intake.The deep mesencephalic nucleus(DpMe)has been implicated in instinctive behaviors.However,whether the DpMe is involved in licking behavior and the precise neural circuit b...
supported by the National Natural Science Foundations of China(81620108008 and 31971112);the Innovation Capability Support Program of Shaanxi Province,China(2021TD-57).
Central sensitization is essential in maintaining chronic pain induced by chronic pancreatitis(CP),but cortical modulation of painful CP remains elusive.Here,we examined the role of the anterior cingulate cortex(ACC)i...
This work was supported by grants from the National Natural Science Foundation of China(81625006,31970923,and 31820103005);the China Postdoctoral Science Foundation(2019M662025).
The cerebellum is conceptualized as a processor of complex movements and is also endowed with roles in cognitive and emotional behaviors.Although the axons of deep cerebellar nuclei are known to project to primary tha...