MONOPHOSPHATE

作品数：92被引量：261H指数：8
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Suppressing high mobility group box-1 release alleviates morphine tolerance via the adenosine5'-monophosphate-activated protein kinase/heme oxygenase-1 pathway被引量：1
《Neural Regeneration Research》2023年第9期2067-2074,共8页Tong-Tong Lin Chun-Yi Jiang Lei Sheng Li Wan Wen Fan Jin-Can Li Xiao-Di Sun Chen-Jie Xu Liang Hu Xue-Feng Wu Yuan Han Wen-Tao Liu Yin-Bing Pan 
supported by the National Natural Science Foundation of China;Nos.81971047 (to WTL) and 82073910 (to XFW);the Natural Science Foundation of Jiangsu Province,No.BK20191253 (to XFW);Key R&D Program (Social Development) Project of Jiangsu Province,No.BE2019 732 (to WTL);Jiangsu Province Hospital (the First Affiliated Hospital of Nanjing Medical University) Clinical Capacity Enhancement Project,No.JSPH-511B2018-8 (to YBP)。
Opioids,such as morphine,are the most potent drugs used to treat pain.Long-term use results in high tolerance to morphine.High mobility group box-1(HMGB1) has been shown to participate in neuropathic or inflammatory p...
关键词：adenosine 5’-monophosphate-activated protein kinase heme oxygenase-1 high mobility group box-1 INTERLEUKIN-1Β MICROGLIA morphine tolerance NEUROINFLAMMATION neuron nuclear factor-κB p65 Toll-like receptor 4 
Investigation and experimental validation of curcumin-related mechanisms against hepatocellular carcinoma based on network pharmacology被引量：4
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2022年第8期682-698,共17页Yang CHEN Qian LI Sisi REN Ting CHEN Bingtao ZHAI Jiangxue CHENG Xiaoyan SHI Liang SONG Yu FAN Dongyan GUO 
supported by the General Project of Shaanxi Science and Technology Plan(No.2021JM-472);the Key Laboratory Project of Education Department of Shaanxi Province(Nos.21JS014 and 21JS007);the Subject Innovation Team of Shaanxi University of Chinese Medicine(No.2019YL14);the Postgraduate Student’s Innovation Project of Shaanxi University of Chinese Medicine(No.2021-09),China。
Objective:To determine the potential molecular mechanisms underlying the therapeutic effect of curcumin on hepatocellular carcinoma(HCC)by network pharmacology and experimental in vitro validation.Methods:The predicti...
关键词：CURCUMIN Network pharmacology p53 Adenosine 5’-monophosphate(AMP)-activated protein kinase(AMPK) Apoptosis AUTOPHAGY 
Amino acids regulate energy utilization through mammalian target of rapamycin complex 1 and adenosine monophosphate activated protein kinase pathway in porcine enterocytes被引量：3
《Animal Nutrition》2020年第1期98-106,共9页Hao Xiao Cuifang Zha Fangyuan Shao Li Wang Bi’e Tan 
funded by the National Natural Science Foundation of China(31672433,31560640),China;Special fund for scientific innovation strategy-construction of high level Academy of Agriculture Science-the Outstanding Talents Training Program of Guangdong Academy of Agricultural Sciences(R2018PY-JC001),China;Special fund for scientific innovation strategy-construction of high level Academy Of Agriculture Science-The Talents Training Program Of Guangdong Academy Of Agricultural Sciences-Young Associate Researcher(R2018PY-QF001),China.
As major fuels for the small intestinal mucosa,dietary amino acids(AA)are catabolized in the mitochondria and serve as sources of energy production.The present study was conducted to investigate AA metabolism that sup...
关键词：Amino acids Mammalian target of RAPAMYCIN ADENOSINE MONOPHOSPHATE ACTIVATED PROTEIN kinase Mitochondrial respiration Energy utilization 
Effects of Mitochondrial Dysfunction via AMPK/PGC-1α Signal Pathway on Pathogenic Mechanism of Diabetic Peripheral Neuropathy and the Protective Effects of Chinese Medicine被引量：25
《Chinese Journal of Integrative Medicine》2019年第5期386-394,共9页ZHANG Qian LIANG Xiao-chun 
Supported by the National Natural Science Foundation of China(No.81473639);the Fundamental Research Funds for the Central Universities(No.3332018037)
Diabetic peripheral neuropathy(DPN) is a progressive neurodegenerative disease of peripheral nervous system with high energy requirement. The adenosine monophosphate-activated protein kinase(AMPK)/peroxisome prolifera...
关键词：monophosphate-activated protein kinase PEROXISOME proliferator-activated receptor-γ COACTIVATOR 1α SIRTUINS diabetic peripheral NEUROPATHY Chinese medicine 
Effects of Ginsenoside Rb1 on Skeletal Muscle Insulin Resistance and Adenosine Monophosphate?activated Protein Kinase Signaling Pathway in Obese Mice被引量：2
《World Journal of Traditional Chinese Medicine》2019年第1期42-49,共8页Dan-Dan Zhao Ying Bai Rui Wu Fang-Fang Mo Chen-Yue Liu Ru-Yuan Zhu Guang-Jian Jiang Jia-Xian Liu Dong-Wei Zhang Si-Hua Gao 
supported by Natural Science Foundation of China (NSFC81503540&NSFC81274041);Chaoyang District Science and Technology Commission Collaborative Innovation Project (CYXC1513);Major New Drug Creation Sub-project (2012ZX09103201-005);Beijing Joint Construction Project (0101216-14&0101216-2013)
Objectives: The objective of the study is to observe the effects of ginsenoside Rb1 on indexes of body weight, body composition, blood lipid, skeletal muscle endurance, and insulin sensitivity in obese mice, probe int...
关键词：ADENOSINE monophosphate-activated protein kinase signaling pathway GINSENOSIDE RB1 insulin resistance obesity skeletal muscle 
5'-Monophosphate-activated protein kinase (AMPK) improves autophagic activity in diabetes and diabetic complications被引量：27
《Acta Pharmaceutica Sinica B》2016年第1期20-25,共6页Fan Yao Ming Zhang Li Chen 
supported by funding from the National Natural Science Foundation of China(No.81170745)
Diabetes mellitus(DM),an endocrine disorder,will be one of the leading causes of death world-wide in about two decades.Cellular injuries and disorders of energy metabolism are two key factors in the pathogenesis of di...
关键词：DIABETES Autophagy AMP-activated protein KINASES DIABETIC COMPLICATIONS 
Dan-gua Fang (丹瓜方) Improves Glycolipid Metabolic Disorders by Promoting Hepatic Adenosine 5'-monophosphate Activated Protein Kinase Expression in Diabetic Goto-kakizaki Rats被引量：12
《Chinese Journal of Integrative Medicine》2015年第3期188-195,共8页蓝元隆 黄苏萍 衡先培 陈玲 李鹏辉 吴静 杨柳清 潘旭东 林彤 程心玲 林青 陈斯歆 
Supported by the National Natural Science Foundation of China(No.81173179);the Natural Science Foundation of Fujian Province(No.2011J01198);the Fujian Medical Innovation Project(No.2009-CX-19);the Research Foundation of Fujian Health Department(No.Zlcnfm02);the Fujian Provincial Department of Education Category A Projects(No.JA09131);the Fujian Health Department of Traditional Chinese Medicine Research(No.WZY0920);the CHEN Ke-ji Integrative Medicine Development Fund(No.CKJ2008047,CKJ2009004);the Integrative Medicine of Fujian Key Laboratory of Age-related Diseases Funded Projects(No.2008J1004-10)
Objective：To investigate the effect of Dan-gua Fang（丹瓜方） on adenosine 5’-monophosphate（AMP） activated protein kinase（AMPK） α expression in liver and subsequent improvement of glucose and lipid metabolism.M...
关键词：Dan-gua Fang Goto-Kakizaki rat adenosine 5’-monophosphate activated protein kinase type 2 diabetes mellitus liver glucose and lipid metabolism 
Adaptive and regulatory mechanisms in aged rats with postoperative cognitive dysfunction被引量：18
《Neural Regeneration Research》2014年第5期534-539,共6页Yanlin Bi Shuyun Liu Xinjuan Yu Mingshan Wang Yuelan Wang 
Inflammation may play a role in postoperative cognitive dysfunction. 5＇ Adenosine monophos- phate-activated protein kinase, nuclear factor-kappa B, interleukin-1β, and tumor necrosis factor-a are involved in inflamm...
关键词：nerve regeneration postoperative cognitive dysfunction SPLENECTOMY BRAIN AGING 5＇ad- enosine monophosphate-activated protein kinase nuclear factor-kappa B tumor necrosis factor-α interleukin- 1β neural regeneration 
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