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Reduced phosphatidylcholine synthesis suppresses the embryonic lethality of seipin deficiency被引量：1
《Life Metabolism》2022年第2期175-189,共15页Jinglin Zhu Sin Man Lam Leilei Yang Jingjing Liang Mei Ding Guanghou Shui Xun Huang 
supported by the National Natural Science Foundation of China(9195420001);the Ministry of Science and Technology of China(2018YFA0506902).
Seipin plays a vital role in lipid droplet homeostasis,and its deficiency causes congenital generalized lipodystrophy type II in humans.It is not known whether the physiological defects are all caused by cellular lipi...
关键词：seipin PHOSPHATIDYLCHOLINE EMBRYOGENESIS lipid droplet 
Aiphanol, a native compound, suppresses angiogenesis via dual-targeting VEGFR2 and C0X2
《Signal Transduction and Targeted Therapy》2022年第1期22-24,共3页Shanmei Chen Junnan Feng Chuanke Zhao Lixin Wang Lin Meng Caiyun Liu Shaoqing Cai Yanxing Jia Like Qu Chengchao Shou 
This study was supported by the National Natural Science Foundation of China(81773219);National Basic Research Program of China(2015CB553906);the PKU-Baidu Fund(2019BD015).
Dear Editor,Pathological neo-vascularization is a hallmark of cancer and several diseases.Accumulating evidence supports the notion that antiangiogenic treatment can abolish tumor angiogenesis to achieve Ion ger disea...
关键词：notion COMPOUND HOUGH 
FAT1, a direct transcriptional target of E2F1, suppresses cell proliferation, migration and invasion in esophageal squamous cell carcinoma被引量：9
《Chinese Journal of Cancer Research》2019年第4期609-619,共11页Yu Wang Guangchao Wang Yunping Ma Jinglei Teng Yan Wang Yongping Cui Yan Dong Shujuan Shao Qimin Zhan Xuefeng Liu 
supported by the National Basic Research Program of China (973 Program) (No. 2015CB553906 and 2015CB553904);the National Natural Science Foundation of China (No. 81490753 and 81830086);the Education Department of Liaoning Province in China (Scientific Research Projects, No. L2016038)
Objective: Growing evidence indicates that FAT atypical cadherin 1(FAT1) has aberrant genetic alterations and exhibits potential tumor suppressive function in esophageal squamous cell carcinoma(ESCC). However, the rol...
关键词：E2F1 ESCC FAT1 tumor SUPPRESSOR 
C11 , a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor, suppresses breast cancer metastasis and angiogenesis被引量：3
《Acta Pharmacologica Sinica》2019年第6期823-832,共10页Zhuo Chen Lin-jiang Tong Bai-you Tang Hong-yan Liu Xin Wang Tao Zhang Xian-wen Cao Yi Chen Hong-lin Li Xu-hong Qian Yu-fang Xu Hua Xie Jian Ding 
National Natural Science Foundation of China (grants 81173080, 81321092, 21236002 and 21302054);National Basic Research Program of China (973 Program, 2010CB126100);National High Technology Research and Development Program of China (863 Program, 2011AA10A207);National Science & Technology Pillar Program (2009ZX09103-102);Shanghai Committee of Science and Technology (grant 13ZR1453100);Fundamental Research Funds for the Central Universities.
The fibroblast growth factor receptors (FGFRs) are increasingly considered attractive targets for therapeutic cancer intervention due to their roles in tumor metastasis and angiogenesis. Here, we identified a new sele...
关键词：C11 FGFR1 INHIBITOR ANTITUMOR BREAST cancer metastasis ANGIOGENESIS 
THZ1 suppresses human non-small-cell lung cancer cells in vitro through interference with cancer metabolism被引量：5
《Acta Pharmacologica Sinica》2019年第6期814-822,共9页Zhu-Jun Cheng Du-Ling Miao Qiu-Yun Su Xiao-Li Tang Xiao-Lei Wang Li Bin Deng Hui Donq Shi Hong-Bo Xin 
National Natural Science Foundation of China (91639106 to H-bX, 81660041 to L-bD);National Basic Research Program of China (2013CB531103 to H-bX and L-bD);Jiangxi Province Science Foundation for Youths (20122BA B215020 to H-wC).
Cancer cells always require more nutrients, energy, and biosynthetic activity to sustain their rapid proliferation than normal cells. Previous studies have shown the impact of THZ1, a covalerrt inhibitor of ryHirwjepe...
关键词：THZ1 CDK7 inhibitor non small CELL lung cancer anti PROLIFERATIVE effect CELL-CYCLE ARREST CELL apoptosis GLYCOLYSIS pathway qlutamine metabolism CB-839 
Mycobacterium tuberculosis Mce2E suppresses the macrophage innate immune response and promotes epithelial cell proliferation被引量：8
《Cellular & Molecular Immunology》2019年第4期380-391,共12页Lihua Qiang Jing Wang Yong Zhang Pupu Ge Qiyao Chai Bingxi Li Yi Shi Lingqiang Zhang George Fu Gao Cui Hua Liu 
This work was supported by research funding from the National Key Research and Development Program of China(Grant Nos.2017YFA0505900 and 2017YFD0500300);the National Basic Research Programs of China(Grant No.2014CB74440);the National Natural Science Foundation of China(Grant Nos.81571536 and 81571954);the Beijing Natural Science Foundation(Grant No.5162021);the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDPB03);the Youth Innovation Promotion Association CAS.
The intracellular pathogen Mycobacterium tuberculosis(Mtb)can survive in the host and cause disease by interfering with a variety of cellular functions.The mammalian cell entry 2(mce2)operon of Mtb has been shown to c...
关键词：Mycobacterium tuberculosis Mce2E innate immune response cell proliferation 
Argininosuccinate synthase 1 suppresses cancer cell invasion by inhibiting STAT3 pathway in hepatocellular carcinoma被引量：5
《Acta Biochimica et Biophysica Sinica》2019年第3期263-276,共14页Xuemei Tao Qiaozhu Zuo Haoyu Ruan Hui Wang Haojie Jin Zhuoan Cheng Yuanyuan Lv Wenxin Qin Cun Wang 
the grants from the National Key Basic Research Program of China(No.2015CB553905);the National Natural Science Foundation of China(Nos.81201626,81402278,81421001,81572311,81672933,and 81772461);the National Key Sci-Tech Special Projects of Infectious Diseases(No.2018ZX10732202-002-003);the Project of Renji Hospital(No.PYXJS16-004);Shanghai Jiao Tong University School of Medicine(No.YG2014MS44);and Shanghai Municipal Commission of Health and Family Planning(No.201640007).
Metastasis is the main reason for high recurrence and poor survival of hepatocellular carcinoma(HCC).The molecular mechanism underlying HCC metastasis remains unclear.In this study,we found that argininosuccinate synt...
关键词：ASS1 HEPATOCELLULAR carcinoma prognosis METASTASIS 
Proteasome inhibition suppresses Th17 cell generation and ameliorates autoimmune development in experimental Sjögren’s syndrome被引量：7
《Cellular & Molecular Immunology》2017年第11期924-934,共11页Fan Xiao Xiang Lin Jie Tian Xiaohui Wang Qian Chen Ke Rui Jie Ma Shengjun Wang Qingwen Wang Xiaoqi Wang Dongzhou Liu Lingyun Sun Liwei Lu 
by grants from the National Natural Science Foundation of China(81373195,91442116,81601424 and 31300739);the National Basic Research Program(No.2014CB541904);the Natural Science Foundation of Jiangsu(Grant No.BK20150533);the General Research Fund,Hong Kong Research Grants Council(No.17114515;17149716);and the Hong Kong Croucher Foundation(260960116).
Immunoproteasome activation in immune cells is involved in the modulation of immune responses.Increasing evidence indicates that proteasome inhibitors show beneficial effects in treating autoimmune diseases,but it rem...
关键词：proteasome inhibition Sjögren’s syndrome Th17 cells 
TIFA suppresses hepatocellular carcinoma progression via MALT1-dependent and-independent signaling pathways被引量：1
《Signal Transduction and Targeted Therapy》2016年第1期81-90,共10页Wenzhi Shen Renle Du Jun Li Xiaohe Luo Shuangtao Zhao Antao Chang Wei Zhou Ruifang Gao Dehong Luo Juan Wang Na Hao Yanhua Liu Yanan Chen Yunping Luo Peiqing Sun Shengyong Yang Na Luo Rong Xiang 
This project is supported by the National Basic Research Program(973)of China(No.2013CB967202);the National Natural Science Foundation of China(No.81273331);the National Natural Science Foundation of China(No.81470354);National Natural Science Foundation of China(81301856;NL).
TIFA,also called T2BP,was first identified using yeast two-hybrid screening.Our previous work showed that TIFA suppresses hepatocellular carcinoma(HCC)progression via apoptosis and cell cycle arrest.However,the mechan...
关键词：MALT1 markedly HEPATOCELLULAR 
Down-regulation of lipocalin 2 suppresses the growth of human lung adenocarcinoma through oxidative stress involving Nrf2/HO-1 signaling被引量：2
《Acta Biochimica et Biophysica Sinica》2015年第10期805-814,共10页Baoquan Song Hairui Zhang Lei Jiang Ying Chi Jianjian Tian Wenjing Du Bentong Yu Zhongchao Han 
This work was supported by the grants from the National Natural Science Foundation of China （Nos. 81330015 and 31470951） and the National Basic Research Program of China （No. 2011CB964802）.
Lipocalin 2 （LCN2）, a multifunctional secretory protein known as neutrophil gelatinase-associated lipocalin （NGAL）, is expressed in a variety of cancers. However, little is known about the biological functions of ...
关键词：neutrophil gelatinase-associated lipocalin lung adenocarcinoma apoptosis reactive oxygen species 
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