EXCITOTOXICITY

作品数：71被引量：272H指数：7
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相关领域：医药卫生更多>>
相关作者：于洋杨柳马春蕾孙晖王天佑更多>>
相关机构：滨州医学院北京市神经外科科研究所山东大学华东师范大学更多>>
相关期刊：《Chinese Journal of Integrative Medicine》《Frontiers in Biology》《Acta Pharmacologica Sinica》《International Journal of Ophthalmology(English edition)》更多>>
相关基金：国家自然科学基金国家教育部博士点基金国家重点基础研究发展计划湖北省自然科学基金更多>>
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Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease
《Neural Regeneration Research》2025年第7期1981-1988,共8页Shan Ping Yu Emily Choi Michael QJiang Ling Wei 
supported by National Health Institute(NIH)grant NS099596(to LW and SPY),NS114221(to LW and SPY);Veterans Affair(VA)SPiRE grant RX003865(to SPY);supported by the O.Wayne Rollins Endowment Fund(to SPY);John E.Steinhaus Endowment Fund(to LW)。
Stroke and Alzheimer's disease are common neurological disorders and often occur in the same individuals.The comorbidity of the two neurological disorders represents a grave health threat to older populations.This rev...
关键词：Ca^(2+)hypothesis cognitive deficits HYPERACTIVITY late-onset Alzheimer's disease NEURODEGENERATION N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment 
Ruxolitinib improves the inflammatory microenvironment,restores glutamate homeostasis,and promotes functional recovery after spinal cord injury被引量：1
《Neural Regeneration Research》2024年第11期2499-2512,共14页Jiang Cao Xiao Yu Jingcheng Liu Jiaju Fu Binyu Wang Chaoqin Wu Sheng Zhang Hongtao Chen Zi Wang Yinyang Xu Tao Sui Jie Chang Xiaojian Cao 
supported by the National Natural Science Foundation of China,No.82272484(to XC).
The inflammatory microenvironment and neurotoxicity can hinder neuronal regeneration and functional recovery after spinal cord injury.Ruxolitinib,a JAK-STAT inhibitor,exhibits effectiveness in autoimmune diseases,arth...
关键词：astrocytes EAAT2 EXCITOTOXICITY glutamate homeostasis JAK-STAT pathway locomotor function NEUROTOXICITY RUXOLITINIB spinal cord injury transcriptome analysis 
p38 MAPK inhibitor SB202190 suppresses ferroptosis in the glutamate-induced retinal excitotoxicity glaucoma model被引量：2
《Neural Regeneration Research》2024年第10期2299-2309,共11页Lemeng Feng Chao Wang Cheng Zhang Wulong Zhang Weiming Zhu Ye He Zhaohua Xia Weitao Song 
supported by the National Natural Science Foundation of China,Nos.81974132,81770927;Hunan Provincial Health Commission,No.20220702839;the Natural Science Foundation of Hunan Province of China,No.2022JJ30076;National Key R&D Program of China,No.2021YFA1101202(all to WS)。
Glutamate excitotoxicity has been shown to play an important role in glaucoma, and glutamate can induce ferroptosis. The p38 mitogenactivated protein kinase(MAPK) pathway inhibitor SB202190 has a potential ability to ...
关键词：ferroptosis GLAUCOMA glutamate excitotoxicity p38 MAPK retinal ganglion cell SB202190 
On implications of somatostatin in diabetic retinopathy
《Neural Regeneration Research》2024年第9期1984-1990,共7页Yanhong Fang Qionghua Wang Youjian Li Li Zeng Jian Liu Kepeng Ou 
supported by the Natural Science Foundation of Chongqing of China,Nos.cstc2020jcyj-msxmX0698(to YF),cstc2021jcyjbshX0147(to KO);a grant from Chongqing Jiangjin District Bureau of Science and Technology,No.Y2022017(to YF).
Somatostatin,a naturally produced neuroprotective peptide,depresses excitatory neurotransmission and exerts anti-proliferative and anti-inflammatory effects on the retina.In this review,we summarize the progress of so...
关键词：diabetes retinopathy EXCITOTOXICITY growth hormone insulin like growth factor irisin NEURODEGENERATION NEUROINFLAMMATION neuroprotection neurovascular unit OCTREOTIDE oxidative stress SOMATOSTATIN 
Adenosine A_(2A)receptor blockade attenuates excitotoxicity in rat striatal medium spiny neurons during an ischemic-like insult
《Neural Regeneration Research》2024年第2期255-257,共3页Elisabetta Coppi Federica Cherchi Alasdair J.Gibb 
supported by University of Florence RICATEN 2023 to EC.Grant/Award Numbers 58514_Internazionalizzazione;University of Florence,to EC.Parkinson’s UK,Grant/Award Number:H-0902 to AJG;Wellcome Trust,Grant/Award Number:0926/Z/10/Z to AJG。
During brain ischemia,excitotoxicity and peri-infarct depolarization injuries occur and cause cerebral tissue damage.Indeed,anoxic depolarization,consisting of massive neuronal depolarization due to the loss of membra...
关键词：adenosine A_(2A)receptors anoxic depolarization brain ischemia glutamate excitotoxicity medium spiny neurons oxygen and glucose deprivation 
Adipose mesenchymal stem cell-derived extracellular vesicles reduce glutamate-induced excitotoxicity in the retina被引量：3
《Neural Regeneration Research》2023年第10期2315-2320,共6页Tian-Qi Duan Zhao-Lin Gao Ai-Xiang Luo Dan Chen Jian-Bin Tong Ju-Fang Huang 
supported by the National Key R&D Program of China,No.2016YFC1201800(to JFH);the Key Research and Development Program of Hunan Province,Nos.2018SK2090(to JFH),2022SK2079(to JFH);the Natural Science Foundation of Hu nan Province,No.2021JJ30891(to DC);the Human Resource Bank Program of Hunan Province,No.2020TP3003(to JFH);the School-Enterprise Joint Program of Central South University,No.2021XQLH092(to TQD)。
Adipose mesenchymal stem cells(ADSCs)have protective effects against glutamate-induced excitotoxicity,but ADSCs are limited in use for treatment of optic nerve injury.Studies have shown that the extracellular vesicles...
关键词：adipose mesenchymal stem cells calcium overload ELECTRORETINOGRAPHY EXCITOTOXICITY extracellular vesicles GluA2 GLUTAMATE protein kinase C alpha R28 cells RETINA retinal ganglion cell 
Neurosteroids as stress modulators and neurotherapeutics: lessons from the retina被引量：1
《Neural Regeneration Research》2023年第5期1004-1008,共5页Yukitoshi Izumi Makoto Ishikawa Toru Nakazawa Hiroshi Kunikata Kota Sato Douglas F.Covey Charles F.Zorumski 
supported by MH101874, MH114866, MH122379 from the National Institute of Mental Health (to CFZ);the Taylor Family Institute for Innovative Psychiatric Research and the Bantly Foundation (to CFZ)。
Neurosteroids are rapidly emerging as important new therapies in neuropsychiatry, with one such agent, brexanolone, already approved for treatment of postpartum depression, and others on the horizon. These steroids ha...
关键词：ALLOPREGNANOLONE autophagy ENANTIOMERS EXCITOTOXICITY gamma-aminobutyric acid type A receptors glaucoma optic nerve OXYSTEROLS 
Polygalasaponin F protects hippocampal neurons against glutamate-induced cytotoxicity
《Neural Regeneration Research》2022年第1期178-184,共7页Chong Sun Xin-Cheng Cao Zhi-Yang Liu Chao-Lin Ma Bao-Ming Li 
supported by the National Natural Science Foundation of China,Nos.31971035(to BML),31771182(to BML),81471116(to BML);the Natural Science Foundation of Jiangxi Province of China,Nos.20171BAB204019(to CS),20192ACB20022(to CS)。
Excess extracellular glutamate leads to excitotoxicity,which induces neuronal death through the overactivation of N-methyl-D-aspartate receptors(NMDARs).Excitotoxicity is thought to be closely related to various acute...
关键词：BDNF Ca^(2+)homeostasis EXCITOTOXICITY GLUTAMATE hippocampal neurons PCREB polygalasaponin F neuroprotection NR2A NR2B 
New solutions for old challenges in glaucoma treatment:is taurine an option to consider?被引量：2
《Neural Regeneration Research》2021年第5期967-971,共5页Igor Iezhitsa Renu Agarwal 
This work was financially supported by the Institut Pengurusan Penyelidikan(RMI),Universiti Teknologi MARA,Malaysia,under grants 600-IRMI/MyRA 5/3/BESTARI(004/2017)and 600-IRMI/MyRA 5/3/BESTARI(006/2017).
Glaucoma is a range of progressive optic neuropathies characterized by progressive retinal ganglion cell loss and visual field defects.It is recognized as a leading cause of irreversible blindness affecting more than ...
关键词：apoptosis EXCITOTOXICITY GLAUCOMA oxidative and nitrosative stresses retinal neuroprotection TAURINE 
Excitotoxicity-induced endocytosis as a potential target for stroke neuroprotection
《Neural Regeneration Research》2021年第2期300-301,共2页Margarita Díaz-Guerra 
BFU2016-75973-R(MINECO/AEI/FEDER,EU)。
Decreased neuronal survival-signaling and brain damage:Stroke is a leading cause of death worldwide,the major cause of adult disability and second of dementia.In spite of the social and economic importance of this dis...
关键词：DRUGS DEATH damage 
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