AGE-RELATED

作品数:152被引量:373H指数:10
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相关领域:医药卫生更多>>
相关作者:陈梅梅颜奕熊浩谢立科王楠更多>>
相关机构:首都医科大学西安外国语大学北京语言大学中国中医科学院眼科医院更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划湖北省自然科学基金广东省自然科学基金更多>>
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  • 期刊=Neural Regeneration Researchx
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Is age-related myelinodegenerative change an initial risk factor of neurodegenerative diseases?
《Neural Regeneration Research》2026年第2期648-658,共11页Shuangchan Wu Jun Chen 
supported by grants from Guangdong Basic and Applied Basic Research Foundation,No.2021A1515110801(to SW);the National Natural Science Foundation of China,No.82301511(to SW);“Double First-Class”Construction Project of NPU,Nos.0515023GH0202320(to JC),0515023SH0201320(to JC)and 973 Program,No.2011CB504100(to JC).
Myelination,the continuous ensheathment of neuronal axons,is a lifelong process in the nervous system that is essential for the precise,temporospatial conduction of action potentials between neurons.Myelin also provid...
关键词:aging Alzheimer’s disease multiple sclerosis MYELIN myelin-axon metabolite crosstalk myelinodegeneration neurodegenerative disease OLIGODENDROCYTE Parkinson’s disease white matter 
Making bridges between preclinical and clinical insights into age-related cognitive decline
《Neural Regeneration Research》2025年第8期2321-2322,共2页David VC Brito Clévio Nóbrega 
Clévio Nóbrega’s laboratory is funded by the Cure CSB project;the Viljem Julijan Association for Children with Rare Diseases(Slovenia);the Algarve Biomedical Center Research Institute(ABC-Ri);funded by CRESC Algarve 2020(Operation Code:ALG-01-0145-FEDER-072586)(to CN)。
With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(Crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether th...
关键词:BRIDGES BECOMING INSIGHT 
Gut microbiota-astrocyte axis: new insights into age-related cognitive decline
《Neural Regeneration Research》2025年第4期990-1008,共19页Lan Zhang Jingge Wei Xilei Liu Dai Li Xiaoqi Pang Fanglian Chen Hailong Cao Ping Lei 
supported by the Haihe Laboratory of Cell Ecosystem Innovation Foundation,No.22HHXBSS00047(to PL);Graduate Science and Technology Innovation Project of Tianjin,No.2022BKY173(to LZ);Tianjin Municipal Science and Technology Bureau Foundation,No.20201194(to PL).
With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent worldwide.Aging is considered the main risk factor for cognitive decline and acts through alterati...
关键词:age aging Alzheimer’s disease ASTROCYTES cognitive decline dementia gut microbiota gut–brain axis microbial metabolites NEUROINFLAMMATION Parkinson’s disease 
Functional phenotyping of microglia highlights the dark relationship between chronic traumatic brain injury and normal age-related pathology被引量:1
《Neural Regeneration Research》2023年第4期811-813,共3页Rodney M.Ritzel Junfang Wu 
supported by the National Institutes of Health Grants K99 NS116032 to RMR and R01 AG077541,RF1 NS110637,2RF1 NS094527,R01 NS110825,and R01 NS110635 to JW。
Traumatic brain injury(TBI) is a major cause of death and disability worldwide. Age-related TBI differences demonstrate the third peak of prevalence and incidence of TBI within the elderly population. This is due to t...
关键词:TBI death injury 
The influence of gut microbiota alteration on age-related neuroinflammation and cognitive decline被引量:2
《Neural Regeneration Research》2022年第11期2407-2412,共6页Amsha S.Alsegiani Zahoor A.Shah 
the College of Pharmacy,Department of Pharmaceutical Chemistry,King Saud University,Riyadh,Saudi Arabia;partly the grants from The American Heart Association,No.17AIREA33700076/ZAS/2017;the National Institute of Neurological Disorders and Stroke of the National Institutes of Health,No.R01NS112642(to ZAS)。
Recent emerging research on intestinal microbiota and its contribution to the central nervous system during health and disease has attra cted significant attention.Age-related intestinal microbiota changes initiate br...
关键词:brain aging cognitive decline DYSBIOSIS fecal microbiota transplantation gut-microbiota NEUROINFLAMMATION PREBIOTICS PROBIOTICS 
Promise of metformin for preventing age-related cognitive dysfunction被引量:1
《Neural Regeneration Research》2022年第3期503-507,共5页Leelavathi N.Madhu Maheedhar Kodali Ashok K.Shetty 
supported by grants from the National Institutes of Health (No.1R01NS106907,to AKS);the Department of Defense (Nos.W81XWH-17-1-0447 and W81XWH-19-1-0548,to AKS)。
The expanded lifespan of people,while a positive advance,has also amplified the prevalence of age-related disorders,which include mild cognitive impairment,dementia,and Alzheimer's disease.Therefore,competent therapie...
关键词:activated microglia aging AUTOPHAGY cognitive dysfunction memory METFORMIN mTOR signaling NEUROINFLAMMATION 
The role of cofilin in age-related neuroinflammation被引量:5
《Neural Regeneration Research》2020年第8期1451-1459,共9页Amsha S.Alsegiani Zahoor A.Shah 
supported by Fellowship from Saudi Arabia Cultural Mission,College of Pharmacy,Department of Pharmaceutical Chemistry,King Saud University,Riyadh,Saudi Arabia
Aging brain becomes susceptible to neurodegenerative diseases due to the shifting of microglia and astrocyte phenotypes to an active“pro-inflammatory”state,causing chronic low-grade neuroinflammation.Despite the fac...
关键词:aging astrocyte-activation COFILIN cofilin inhibitor cofilin/actin rods INFLAMMAGING microglial activation NEUROGENESIS NEUROINFLAMMATION 
Aging gracefully: social engagement joins exercise and enrichment as a key lifestyle factor in resistance to age-related cognitive decline被引量:1
《Neural Regeneration Research》2019年第1期39-42,共4页Tyler J.Dause Elizabeth D.Kirby 
partially supported by a R00 Pathway to Independence Award from NIH/NINDS(R00NS089938)(to EDK)
Cognitive impairment is a consequence of the normal aging process that effects many species, including humans and rodent models. Decline in hippocampal memory function is especially prominent with age and often reduce...
关键词:AGING age-related cognitive decline social engagement HIPPOCAMPUS cognitive enrichment EXERCISE memory NEUROGENESIS 
Epigenetic interventions for brain rejuvenation:anchoring age-related transposons被引量:1
《Neural Regeneration Research》2018年第4期635-636,共2页Adonis Sfera Lisa Fayard Carolina Osorio Amy Price 
Highlights:1.Iron and homocysteine accumulation in aging neurons alter genomic methylation.2.The altered methylome reactivates neuronal cell cycle,enabling transposable element mobilization.3.mi R29/p53 axis restores...
关键词:Epigenetic interventions for brain rejuvenation:anchoring age-related transposons PUFAs DNA Figure TE cycle 
Saponins from Panax japonicus attenuate age-related neuroinflammation via regulation of the mitogen-activated protein kinase and nuclear factor kappa B signaling pathways被引量:18
《Neural Regeneration Research》2017年第11期1877-1884,共8页Li-li Deng Ding Yuan Zhi-yong Zhou Jing-zhi Wan Chang-cheng Zhang Chao-qi Liu Yao-yan Dun Hai-xia Zhao Bo Zhao Yuan-jian Yang Ting Wang 
supported by the National Natural Science Foundation of China,No.81374001,81673778,81273895;the Foundation for Innovative Research Groups of the Natural Science Foundation of Hubei Province of China,No.2013CFA014
Neuroinflammation is recognized as an important pathogenic factor for aging and related cognitive disorders. Mitogen-activated protein kinase and nuclear factor kappa B signaling pathways may mediate neuroinflammation...
关键词:Saponlns Panaxjaponicus attenuate age-related neuroinflammation 
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