supported by grants from Guangdong Basic and Applied Basic Research Foundation,No.2021A1515110801(to SW);the National Natural Science Foundation of China,No.82301511(to SW);“Double First-Class”Construction Project of NPU,Nos.0515023GH0202320(to JC),0515023SH0201320(to JC)and 973 Program,No.2011CB504100(to JC).
Myelination,the continuous ensheathment of neuronal axons,is a lifelong process in the nervous system that is essential for the precise,temporospatial conduction of action potentials between neurons.Myelin also provid...
Clévio Nóbrega’s laboratory is funded by the Cure CSB project;the Viljem Julijan Association for Children with Rare Diseases(Slovenia);the Algarve Biomedical Center Research Institute(ABC-Ri);funded by CRESC Algarve 2020(Operation Code:ALG-01-0145-FEDER-072586)(to CN)。
With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(Crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether th...
supported by the Haihe Laboratory of Cell Ecosystem Innovation Foundation,No.22HHXBSS00047(to PL);Graduate Science and Technology Innovation Project of Tianjin,No.2022BKY173(to LZ);Tianjin Municipal Science and Technology Bureau Foundation,No.20201194(to PL).
With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent worldwide.Aging is considered the main risk factor for cognitive decline and acts through alterati...
supported by the National Institutes of Health Grants K99 NS116032 to RMR and R01 AG077541,RF1 NS110637,2RF1 NS094527,R01 NS110825,and R01 NS110635 to JW。
Traumatic brain injury(TBI) is a major cause of death and disability worldwide. Age-related TBI differences demonstrate the third peak of prevalence and incidence of TBI within the elderly population. This is due to t...
the College of Pharmacy,Department of Pharmaceutical Chemistry,King Saud University,Riyadh,Saudi Arabia;partly the grants from The American Heart Association,No.17AIREA33700076/ZAS/2017;the National Institute of Neurological Disorders and Stroke of the National Institutes of Health,No.R01NS112642(to ZAS)。
Recent emerging research on intestinal microbiota and its contribution to the central nervous system during health and disease has attra cted significant attention.Age-related intestinal microbiota changes initiate br...
supported by grants from the National Institutes of Health (No.1R01NS106907,to AKS);the Department of Defense (Nos.W81XWH-17-1-0447 and W81XWH-19-1-0548,to AKS)。
The expanded lifespan of people,while a positive advance,has also amplified the prevalence of age-related disorders,which include mild cognitive impairment,dementia,and Alzheimer's disease.Therefore,competent therapie...
supported by Fellowship from Saudi Arabia Cultural Mission,College of Pharmacy,Department of Pharmaceutical Chemistry,King Saud University,Riyadh,Saudi Arabia
Aging brain becomes susceptible to neurodegenerative diseases due to the shifting of microglia and astrocyte phenotypes to an active“pro-inflammatory”state,causing chronic low-grade neuroinflammation.Despite the fac...
partially supported by a R00 Pathway to Independence Award from NIH/NINDS(R00NS089938)(to EDK)
Cognitive impairment is a consequence of the normal aging process that effects many species, including humans and rodent models. Decline in hippocampal memory function is especially prominent with age and often reduce...
supported by the National Natural Science Foundation of China,No.81374001,81673778,81273895;the Foundation for Innovative Research Groups of the Natural Science Foundation of Hubei Province of China,No.2013CFA014
Neuroinflammation is recognized as an important pathogenic factor for aging and related cognitive disorders. Mitogen-activated protein kinase and nuclear factor kappa B signaling pathways may mediate neuroinflammation...