The kidneys play a critical role in maintaining glucose homeostasis.Under normal renal tubular function,most of the glucose filtered from the glomeruli is re-absorbed in the proximal tubules,leaving only trace amounts...
supported by the China Postdoctoral Science Foundation(No.2023M740731);Fundamental Research Funds for the Central Universities(No.SWU-KQ22024);National Key Research and Development Program of China(No.2021YFD1800900);National Natural Science Foundation of China(No.82073790);the Chongqing Science and Technology Commission(No.CSTB2022TIAD-LUX0001)。
In polarized cells,the differential distribution of proteins results in the formation of apical and basolateral membranes.The basolateral membrane contacts basal lamina and mediates cell-to-cell communication,which is...
This work was supported by grants from the Foundation for Innovative Research Groups of NSFC(No.81721005 to JGC and FW);the National Basic Research Program of China(973 Program,No.2014CB744601 to FW and No.2013CB531303 to JGC);National Natural Science Foundation of China(No.81773712 to PFW,No.81803503 to XLG,No.81471377 to FW,No.81473198 to JGC);Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province(2015CFA020)and PCSIRT(No.IRT13016)to JGC.
Individual differences in the development of uncontrollable fear in response to traumatic stressors have been observed in clinic, but the underlying mechanisms remain unknown. In the present study we first conducted a...
This work was supported in part by the Key-Area Research and Development Program of Guangdong Province(2018B030331001 and 2018B030338001);the National Natural Science Foundation of China(31600860,31630031,31930047,and 91732304);the International Partnership Program of the Chinese Academy of Sciences(172644KYS820170004);the Key Laboratory of the CAS(2019DP173024);the Strategic Priority Research Program of Chinese Academy of Science(XDB32030100);the Guangdong Provincial Key Laboratory of Brain Connectome and Behavior(2017B030301017);the Ten Thousand Talent Program,the Chang Jiang Scholars Program,the Guangdong Special Support Program,the Guangdong Provincial Natural Science Foundation(2018A030313439);the Helmholtz-CAS joint research grant(GJHZ1508);the Shenzhen Government Basic Research Grants(JCYJ20170413164535041);the Shenzhen Key Science and Technology Infrastructure Planning Project(ZDKJ20190204002)。
Dear Editor,Tonic immobility(TI),also termed"feigning death," is the ultimate defensive response to in escapable threats.Since some predators do not like to eat dead animals.
BACKGROUND: The role of the amygdala in controlling emotional pain has been emphasized in several studies. In this study, the role of the NMDA glutamate receptors in the basolateral nucleus of the amygdala (BLA) in...
This study was aimed to determine the effect of amygdaline inactivation on the sexual motivation of male rats during a T-maze task with a sexual reward. Subjects were chronically implanted with two stainless-steel can...
supported by CAPES/PROEX,FAPESP(2010/10936-5);A.F.Donatti has a doctorate scholarship from CAPES;C.R.A.Leite-Panissi also received grants from the CNPq(Grant No.307383/2012-1).
Corticotropin-releasing factor (CRF) is a peptide that is released from the hypothalamus into widespread areas of the brain. Evidence has suggested that CRF is involved as a neuromodulator outside of the hypothalamic-...
Background Glucocorticoid receptor (GR) is believed to be a major factor in brain maturation and in modulation of a series of brain activity. Hippocampal neurons are abundant in glucocorticoid receptor, and there is...
Supported by VU University Medical Center,Amsterdam,The Netherlands
AIM:To assess whether glutamate plays a similar role to glutamine in preserving gut wall integrity.METHODS:The effects of glutamine and glutamate on induced hyperpermeability in intestinal cell lines were studied.Para...
Supported by A Grant From the Dietmar Hopp Foundation (Stremmel WR);the Post-Doc programme of the Medical Faculty of the University of Heidelberg (Gotthardt D and Braun A)
AIM:To investigate whether the secretion of phospha-tidylcholine(PC)in intestinal mucus occurs by apical secretion or via basolateral excretion and to determine its subsequent passage across the tight junctions to the...