云南高校图书馆联盟文献共享服务平台- PHARMACOKINETIC

PHARMACOKINETIC: 作品数：198被引量：425H指数：10; 导出分析报告; 相关作者：程远国王艺林玮玮王琰肇丽梅更多>>; 相关机构：军事医学科学院山东大学河北医科大学首都医科大学附属北京天坛医院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金河北省自然科学基金更多>>

Biopharmaceutical and pharmacokinetic attributes to drive nanoformulations of small molecule tyrosine kinase inhibitors: 《Asian Journal of Pharmaceutical Sciences》2024年第6期48-83,共36页Soumyadip Mukherjee Vedant Joshi Kolimi Prashanth Reddy Nidhi Singh Priyanka Das Pallab Datta; Buoyed by the discovery of small-molecule tyrosine kinase inhibitors(smTKIs),significant impact has been made in cancer chemotherapeutics.However,some of these agents still encounter off-target toxicities and suboptim...; 关键词：PHARMACOKINETICS Tyrosine kinase inhibitors NANOPARTICLES Liposomes Peak plasma concentration

Aspects of high-performance and bio-acceptable magnetic nanoparticles for biomedical application被引量：1: 《Asian Journal of Pharmaceutical Sciences》2021年第6期704-737,共34页Preeti Kush Parveen Kumar Ranjit Singh Ajeet Kaushik; Parveen Kumar acknowledges the department of science and technology(DST);New Delhi for the INSPIRE(Innovation in Science Pursuit for Inspired Research)-Faculty grant.; This review covers extensively the synthesis&surface modification,characterization,and application of magnetic nanoparticles.For biomedical applications,consideration should be given to factors such as design strategi...; 关键词：MAGNETISM Synthesis Characterization Delivery Imaging BIODISTRIBUTION PHARMACOKINETIC

Development of a method to quantify total and free irinotecan and 7-ethyl-10-hydroxycamptothecin(SN-38) for pharmacokinetic and bio-distribution studies after administration of irinotecan liposomal formulation被引量：4: 《Asian Journal of Pharmaceutical Sciences》2019年第6期687-697,共11页Wenqian Yang Zimeng Yang Jieru Liu Dan Liu Yongjun Wang; In 2015,liposomal formulation of irinotecan(ONIVYDE)has been approved by FDA and widely applied in the treatment of pancreatic cancer.ONIVYDE is a novel liposome formulation,entrapping CPT-11 in the aqueous core of ve...; 关键词：IRINOTECAN Liposome UPLC-MS-MS SPE Pharmacokinetics Bio-distribution

Tunable and sustained-release characteristics of venlafaxine hydrochloride from chitosan–carbomer matrix tablets based on in situ formed polyelectrolyte complex film coating被引量：1: 《Asian Journal of Pharmaceutical Sciences》2018年第6期566-574,共9页Xiaofei Zhang Xiangqin Gu Xiaodan Wang Huimin Wang Shirui Mao; supported by the Distinguished Professor Project of Liaoning Province(2015); The objective of this study is to design sustained-release tablets using matrix technology, which can well control the release of highly water-soluble drugs with good system robustness and simple preparation process. ...; 关键词：VENLAFAXINE HYDROCHLORIDE POLYELECTROLYTE complex SUSTAINED-RELEASE Robustness PHARMACOKINETIC

Effects of tomato juice on the pharmacokinetics of CYP3A4-substrate drugs被引量：1: 《Asian Journal of Pharmaceutical Sciences》2017年第5期464-469,共6页Atsuko Ohkubo Tomomi Chida Hidetomo Kikuchi Tadashi Tsuda Katsuyoshi Sunaga; We previously demonstrated that tomato juice(TJ) contains potent mechanism-based inhibitor(s) of CYP3A4. In this study, we investigated the effects of TJ and grapefruit juice(GFJ)on the pharmacokinetics of the CYP3A4-...; 关键词：Food–drug INTERACTIONS Tomato JUICE GRAPEFRUIT JUICE NIFEDIPINE MIDAZOLAM PHARMACOKINETIC INTERACTIONS

Influence of pretreatment of piperazine ferulate on pharmacokinetic parameters of methotrexate in methotrexate-induced renal injury model rats by HPLC-MS: 《Asian Journal of Pharmaceutical Sciences》2017年第2期202-208,共7页Huiyan Shi Chenzhi Hou Liqiang Gu Zhe Wei Hang Xing Meiyu Zhang Shixiao Wang Longshan Zhao Kaishun Bi Xiaohui Chen; The present study was designed to investigate the influence of the pretreatment of piperazine ferulate on pharmacokinetic parameters of methotrexate in methotrexate-induced renal injury rats.A simple and efficient hig...; 关键词：METHOTREXATE PIPERAZINE FERULATE PHARMACOKINETIC parameters HPLC-MS

Virtual population pharmacokinetic using physiologically based pharmacokinetic model for evaluating bioequivalence of oral lacidipine formulations in dogs被引量：5: 《Asian Journal of Pharmaceutical Sciences》2017年第1期98-104,共7页Bin Yang Chunnuan Wu Bin Ji Mingrui Wu Zhonggui He Lei Shang Jin Sun; the National Natural Science Foundation of China (No. 81173009);the Technology Bureau in Shenyang (No. ZCJJ2013402);the Project for New Century Excellent Talents of Ministry of Education (No. NCET-12-1015); The aim of the present study was to investigate virtual population pharmacokinetic using physiologically based pharmacokinetic(PBPK) model for evaluating bioequivalence of oral lacidipine formulations in dogs. The dis...; 关键词：Physiologically based PHARMACOKINETIC model VIRTUAL POPULATION PHARMACOKINETIC BIOEQUIVALENCE LACIDIPINE Amorphous solid DISPERSIONS

Liposomes for systematic delivery of vancomycin hydrochloride to decrease nephrotoxicity:Characterization and evaluation被引量：4: 《Asian Journal of Pharmaceutical Sciences》2015年第3期212-222,共11页Junli Liu Zhonglan Wang Fubing Li Jinhua Gao Longmei Wang Guihua Huang; Vancomycin hydrochloride(VANH),the first glycopeptide antibiotic,is a water-soluble drug for the treatment of acute osteomyelitis.Liposomal formulations of VANH have already been manipulated and characterized,which wa...; 关键词：BIODISTRIBUTION NEPHROTOXICITY PHARMACOKINETIC Systematic delivery Vancomycin hydrochloride LIPOSOME

Design and evaluation of nicorandil extended-release tablet: 《Asian Journal of Pharmaceutical Sciences》2015年第2期108-113,共6页Ju-Young Kim Chun-Woong Park Beom-Jin Lee Eun-Seok Park Yun-Seok Rhee; supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Korean Ministry of Education,Science and Technology(NRF-2012R1A1A1013210);by a grant of the Korean Health Technology R&D Project,Ministry of Health,Welfare&Family Affairs,Republic of Korea(A092018).; The aim of this study was to design and evaluate extended-release formulations of a model drug,nicorandil,in order to achieve the desired steady-state plasma concentration of drug in vivo.Simulation was employed to es...; 关键词：NICORANDIL In vitro In vivo PHARMACOKINETIC EXTENDED-RELEASE

Pharmacokinetic performance of the nitrendipine intravenous submicron emulsion in rats: 《Asian Journal of Pharmaceutical Sciences》2014年第6期330-335,共6页Jibin Guan Nana Zhao Yinglei Zhai Chunxia Chu Hongming Chen Tianhong Zhang; To compare pharmacokinetic behaviors of nitrendipine submicron emulsion with nitrendipine solution following intravenous administration in rats.The plasma concentrations were analyzed by ultra-performance liquid chrom...; 关键词：NITRENDIPINE Submicron emulsion BIOAVAILABILITY Method validation

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