SUBTYPES

作品数：243被引量：586H指数：10
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相关领域：医药卫生更多>>
相关作者：张军刘贵生龚均常英程鹏更多>>
相关机构：中国医科大学中山大学郑州大学第一附属医院西安交通大学医学院第二附属医院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>
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Establishing age-group specific reference intervals of human salivary proteome and its preliminary application for epilepsy diagnosis
《Science China(Life Sciences)》2025年第3期809-824,共16页Nianci Xue Xia Xia Yini Wang Xianju Li Nairen Zheng Yi Wang Baoying Gong Bin Zhang Yanjia Chen Yue Chen Yanjuan Li Hong Cao Wofeng Liu Hongqiang Huang Shuo Yang Lisen Sui Lin Meng Jianwen Guo Jun Qin 
supported by the National Natural Science Foundation of China(32088101,32271498);the National Key Research and Development Program of China(2022YFA1303200);State Key Laboratory of Proteomics(SKLP-K202002);State Key Laboratory of Dampness Syndrome of Chinese Medicine,The Second Affiliated Hospital of Guangzhou University of Chinese Medicine(SZ2021ZZ06,SZ2021ZZ3205);Key-Area Research and Development Program of Guangdong Province(2020B1111100009);Guangzhou Science and Technology Plan Project(202102010275,202201020499).
Salivary proteins serve multifaceted roles in maintaining oral health and hold significant potential for diagnosing and monitoring diseases due to the non-invasive nature of saliva sampling.However,the clinical utilit...
关键词：reference intervals saliva proteomics EPILEPSY biomarker disease subtypes 
Single-cell transcriptomic profiling reveals ZEB1-mediated regulation in microglial subtypes and the impact of exercise on neuroinflammatory responses
《Traditional Medicine Research》2025年第2期55-64,共10页Jin-Fang Wu Yi-Sheng Chen Yu-Chun Xie 
Background:This study aims to identify distinct cellular subtypes within brain tissue using single-cell transcriptomic analysis,focusing on specific biomarkers that differentiate cell types and the effects of traditio...
关键词：single-cell transcriptomics brain tissue cellular subtypes biomarker expression neuronal diversity 
Microglia subtypes in Alzheimer’s disease: insights from single-cell omics
《Journal of Translational Neuroscience》2024年第4期14-22,共9页Ruikang Han Feng Li 
Microglia are immune-competent cells involved in maintaining brain homeostasis through their capacity to prune synapses and continuously survey the brain environment.The activation of microglia is one of the most prom...
关键词：MICROGLIA Alzheimer’s disease im-munity SUBTYPE heterogeneity NEUROINFLAMMATION lipid metabolism 
Single-cell analyses revealed key tumor-infiltrating myeloid cell subsets associated with clinical outcomes in different subtypes of breast cancer
《Genes & Diseases》2024年第6期32-35,共4页Dingjie Wu Si Chen Yijin Liu Bowen Yang Ruixin Li Feng Jin Fan Yao Yue Fang 
supported by the National Natural Science Foundation of China (No.81974418);Basic Research Project of Liaoning Province (No.JC2019002);Doctoral Start-up Foundation of Liaoning Province (No.2019-BS-284);Youth backbone Support Program of China Medical University (No.QGZ2018081).
Breast cancer is the most common cancer and the leading cause of cancer death in women worldwide.1 Tumor-infiltrating myeloid cells(TiMs),key components of tumor microenvironment,are considered to be potential therape...
关键词：BREAST infiltrating MYELOID 
Integrated chromosomal instability and tumor microbiome re define d prognosis-related subtypes of pancreatic cancer
《Hepatobiliary & Pancreatic Diseases International》2024年第6期620-627,共8页Rui-Han Chen Jia-Ying Cao Shi Feng Hai-Tao Huang Yi-Mou Lin Jing-Yu Jiang Xue-Wen Yi Qi Ling 
supported by grants from the National Natural Science Foundation of China(82171757);the Zhejiang Provincial Natural Science Foundation of China(LZ22H030004 and LQ20H160048).
Background:Pancreatic cancer is a common malignancy with poor prognosis and limited treatment.Here we aimed to investigate the role of host chromosomal instability(CIN)and tumor microbiome in the prognosis of pancreat...
关键词：Pancreatic cancer Chromosomal instability MICROBIOME Molecular subtype 
Identification of ferroptosis-associated tumor antigens as the potential targets to prevent head and neck squamous cell carcinoma
《Genes & Diseases》2024年第6期482-494,共13页Qiming Zhai Zhiwei Wang Han Tang Shanshan Hu Meihua Chen Ping Ji 
sponsored by the National Natural Science Foundation of China (No.82201059,82071115);Beijing Xisike Clinical Oncology Research Foundation (China) (No.Y-XD202001-0024);the Chongqing Postdoctoral Science Special Foundation (China) (No.2021XM1031);the Natural Science Foundation of Chongqing,China (No.CSTB2022NSCQ-BHX0003);China Postdoctoral Science Foundation (No.2022M720599).
Head and neck squamous cell carcinoma(HNSC)represents nearly 90%of all head and neck tumors.The current treatment modality for HNSC patients primarily involves surgical intervention and radiotherapy,but its therapeuti...
关键词：Ferroptosis Ferroptosis subtypes Head and neck squamous cell carcinoma IMMUNOTHERAPY Tumorantigens 
Identifying genetic targets in clinical subtypes of Parkinson’s disease for optimizing pharmacological treatment strategies
《Signal Transduction and Targeted Therapy》2024年第12期5708-5719,共12页Dewen Kong Cao Li LingYan Ma Lida Du Nan Jiang Xiaoyue Zhao Sen Zhang Zhigang Zhao Lianhua Fang Guanhua Du 
supported by Beijing Natural Science Foundation(7232258);the CAMS Innovation Fund for Medical Sciences(2022-I2M-1-005);the Key R&D Program of Shan Dong Province(No.2019JZZY020909).
The heterogeneity of Parkinson’s disease(PD)has been recognized in clinical,with patients categorized into distinct subsets based on motor phenotype,such as tremor-dominant PD(TD),postural instability and gait diffic...
关键词：clinical SUBTYPES alterations 
Risk factors and birth outcomes of preterm birth subtypes:a case-control study of singleton natural pregnancy
《Gynecology and Obstetrics Clinical Medicine》2024年第3期136-142,共7页Yonghong Jiang Fang Zhou Haokun Zhang Hui Zhang Songchang Chen Edward Allen Hongyan Chen Chenming Xu Daru Lu 
Objective The objective of the study was to identify the risk factors correlated with spontaneous preterm birth(SPTB)and iatrogenic preterm birth(IPTB),as well as to compare the pregnancy outcomes between SPTB and IPT...
关键词：PREGNANCY DISTRESS BIRTH 
Communication between cancer cell subtypes by exosomes contributes to nasopharyngeal carcinoma metastasis and poor prognosis
《Precision Clinical Medicine》2024年第3期265-278,共14页Hao-Jun Xie Ming-jie Jiang Ke Jiang Lin-Quan Tang Qiu-Yan Chen An-Kui Yang Hai-Qiang Mai 
supported by grants from the National Key Research and Development Program of China(Grant Nos.2022YFC2505800,2022YFC2705005);the National Natural Science Foundation of China(Grant Nos.32200651,82203776,82203125,82222050,82272739,82272882,82173287,82073003,82003267,82002852);Guangdong Basic and Applied Basic Research Foundation(Grant Nos.2021B1515230002,2022A1515110033);Science and Technology Program of Guangzhou(Grant Nos.202201011561,2023A04J2127);Sun Yat-sen University Clinical Research 5010 Program(Grant Nos.201315,2015021,2017010,2019023);Innovative Research Team of High-level Local Universities in Shanghai(Grant No.SSMU-ZLCX20180500);Postdoctoral Innovative Talent Support Program(Grant No.BX20220361);Planned Science and Technology Project of Guangdong Province(Grant No.2019B020230002);Key Youth Teacher Cultivating Program of Sun Yat-sen University(Grant No.20ykzd24),and Fundamental Research Funds for the Central Universities.
Background:Intratumor heterogeneity is common in cancers,with different cell subtypes supporting each other to become more malignant.Nasopharyngeal carcinoma(NPC),a highly metastatic cancer,shows significant heterogen...
关键词：cell heterogeneity cell communication EXOSOMES METASTASIS nasopharyngeal carcinoma 
A cohort study of ten-year cardiovascular disease risk among subtypes of pre-diabetes population aged 40 and above in Guiyang urban area
《China Medical Abstracts(Internal Medicine)》2024年第3期158-158,共1页CHEN Yi 
Objective To investigate the 10-year risk for cardiovascular diseases (CVD) among different subtypes of pre-diabetes (Pre-DM) residents aged 40 and above in Guiyang urban area and to analyze the influencing factors.
关键词：CARDIOVASCULAR DIABETES Guiyang 
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