INFLAMMASOME

作品数：391被引量：2615H指数：23
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相关领域：医药卫生更多>>
相关作者：韩蓉吴东明吴玉章许颖陈永文更多>>
相关机构：第二军医大学广州医科大学华中科技大学安徽医科大学更多>>
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相关基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划上海市自然科学基金更多>>
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Runchangningshen paste activates NLRP6 inflammasome-mediated autophagy to stimulate colonic mucin-2 secretion and modulates mucosal microbiota in functional constipation
《World Journal of Gastroenterology》2025年第9期100-134,共35页Xue-Jiao Liu Ye-li-ya Ye-er-tai Yue-Bo Jia Chen-Heng Wu Xiang-Xiang Wang Ke-Ming Yang Xuan Yao Jiang-Hong Ling 
Supported by National Natural Science Foundation of China,No.82174309;and Shanghai Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Siming Fund Special Project for Scientific Research,No.SGKJ-202304.
BACKGROUND Runchangningshen paste(RCNSP)is a paste made of four medicinal and edible homologous Chinese medicine mixed with honey.It is known for its ability to nourish yin and blood as well as to loosen the bowel to ...
关键词：Traditional Chinese medicine Functional constipation NLRP6 AUTOPHAGY Mucosal microbiota MUCIN Goblet cells 
Emerging role of exosomes in ulcerative colitis: Targeting NOD-like receptor family pyrin domain containing 3 inflammasome被引量：2
《World Journal of Gastroenterology》2024年第6期527-541,共15页Xin Li Li-Jiang Ji Kai-Di Feng Hua Huang Mei-Rou Liang Shi-Jin Cheng Xiu-Dong Meng 
Supported by Guizhou University of Traditional Chinese Medicine Doctoral Initiation Fund,No.202306;and Changshu Municipal Science and Technology Bureau Supporting Project,No.CS202030.
Ulcerative colitis(UC)is a chronic recurrent inflammatory bowel disease.Despite ongoing advances in our understanding of UC,its pathogenesis is yet unelu-cidated,underscoring the urgent need for novel treatment strate...
关键词：Ulcerative colitis EXOSOMES INFLAMMASOME Evidence THERAPEUTICS 
SLC6A14 promotes ulcerative colitis progression by facilitating NLRP3 inflammasome-mediated pyroptosis被引量：1
《World Journal of Gastroenterology》2024年第3期252-267,共16页Qing Gu Huan Xia Yue-Qiong Song Jun Duan Yun Chen You Zhang He-Ping Chen Li Zhang 
Supported by The Key Research and Development Projects of Sichuan Science and Technology Department,No.2023YFS0285;Natural Science Foundation Project of Sichuan Science and Technology Department,No.2023NSFSC0613.
BACKGROUND Ulcerative colitis(UC)is an inflammatory condition with frequent relapse and recurrence.Evidence suggests the involvement of SLC6A14 in UC pathogenesis,but the central regulator remains unknown.AIM To explo...
关键词：Ulcerative colitis SLC6A1 NLRP3 PYROPTOSIS INFLAMMASOME 
Effect and mechanism of reactive oxygen species-mediated NOD-like receptor family pyrin domain-containing 3 inflammasome activation in hepatic alveolar echinococcosis被引量：1
《World Journal of Gastroenterology》2023年第14期2153-2171,共19页Cai-Song Chen Yao-Gang Zhang Hai-Jiu Wang Hai-Ning Fan 
Supported by the National Major Research and Development Project of“Precision Medicine Research”,No.2017YFC0909900;Qinghai Province Science and Technology Department Programme,No.2019-SF-131;the Qinghai Province Health and Family Planning Commission Programme,No.2016-wjzd-04.
BACKGROUND The NOD-like receptor family pyrin domain-containing 3(NLRP3)inflammasome is a significant component of the innate immune system that plays a vital role in the development of various parasitic diseases.Howe...
关键词：Hepatic alveolar echinococcosis INFLAMMASOME Inflammation Kupffer cell NLR family pyrin domain-containing 3 protein Reactive oxygen species 
Therapeutic interventions target the NLRP3 inflammasome in ulcerative colitis:Comprehensive study被引量：2
《World Journal of Gastroenterology》2023年第6期1026-1053,共28页Fares E.M Ali Islam M.Ibrahim Osama M Ghogar Esraa K.Abd-alhameed Hanan S.Althagafy Emad H.M.Hassanein 
One of the significant health issues in the world is the prevalence of ulcerative colitis(UC).UC is a chronic disorder that mainly affects the colon,beginning with the rectum,and can progress from asymptomatic mild in...
关键词：Ulcerative colitis NLR family pyrin domain containing 3 inflammasome Therapeutic strategies PHYTOCHEMICALS PROBIOTICS 
Tamarix chinensis Lour inhibits chronic ethanol-induced liver injury in mice被引量：6
《World Journal of Gastroenterology》2020年第12期1286-1297,共12页Zhi-Dan Wang Yu Zhang Yi-Dan Dai Ke Ren Chen Han Heng-Xiao Wang Shuang-Qin Yi 
the Innovation Project of Shandong Academy of Medical Science;the Science and Technology Major Project of Shandong province,No.2015ZDJS03002.
BACKGROUND Tamarix chinensis Lour(TCL)is a shrub that usually grows in arid or semiarid desert areas and saline-alkali fields.It is a traditional Chinese herbal medicine with hepatoprotective,antioxidant,antibacterial...
关键词：TAMARIX chinensis Lour ALCOHOLIC LIVER disease Ethanol-induced LIVER injury NLRP3 INFLAMMASOME Oxidative stress Natural KILLER T cells 
Role of NLRP3 inflammasome in inflammatory bowel diseases被引量：38
《World Journal of Gastroenterology》2019年第33期4796-4804,共9页Evanthia Tourkochristou Ioanna Aggeletopoulou Christos Konstantakis Christos Triantos 
Inflammasomes are multiprotein intracellular complexes which are responsible for the activation of inflammatory responses. Among various subtypes of inflammasomes, NLRP3 has been a subject of intensive investigation. ...
关键词：NLRP3 INFLAMMASOME Inflammatory BOWEL diseases MUCOSAL immune system INTERLEUKIN 1β INTERLEUKIN 18 NLRP3 gene POLYMORPHISMS 
Effect of mild moxibustion on intestinal microbiota and NLRP6 inflammasome signaling in rats with post-inflammatory irritable bowel syndrome被引量：51
《World Journal of Gastroenterology》2019年第32期4696-4714,共19页Chun-Hui Bao Chun-Ye Wang Guo-Na Li Yi-Lu Yan Di Wang Xiao-Ming Jin Lu-Yi Wu Hui-Rong Liu Xiao-Mei Wang Zheng Shi Huan-Gan Wu 
Supported by the National Natural Science Foundation of China,No.81503656;the National Key Basic Research Program of China(973 Program),No.2015CB554501 and No.2009CB522900
BACKGROUND About one-third of refractory irritable bowel syndrome(IBS)cases are caused by gastrointestinal(GI)infection/inflammation,known as post-infectious/postinflammatory IBS(PI-IBS).Although it is known that inte...
关键词：Moxibustion Post-inflammation IRRITABLE bowel syndrome INTESTINAL microbes NLRP6 INFLAMMASOME INTESTINAL INFLAMMATION Visceral HYPERSENSITIVITY Traditional Chinese medicine 
Dietary saturated fatty acid and polyunsaturated fatty acid oppositely affect hepatic NOD-like receptor protein 3 inflammasome through regulating nuclear factor-kappa B activation被引量：11
《World Journal of Gastroenterology》2016年第8期2533-2544,共12页Yong-heng Sui Wen-jing Luo Qin-Yu Xu jing hua 
Supported by The National Natural Science Foundation of China;NO.81170374 and NO.81470842 to Hua J
AIM: To investigate the effect of different dietary fatty acids on hepatic inflammasome activation.METHODS: Wild-type C57BL/6 mice were fed either a high-fat diet or polyunsaturated fatty acid (PUFA)-enriched diet. Pr...
关键词：Non-alcoholic fatty liver disease NOD-like receptor protein 3 inflammasome Saturated fatty acids Polyunsaturated fatty acids Nuclear factor-kappa B 
Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease被引量：9
《World Journal of Gastroenterology》2015年第45期12787-12799,共13页Hyun Jung Lee Jong Eun Yeon Eun Jung Ko Eileen L Yoon Sang Jun Suh Keunhee Kang Hae Rim Kim Seoung Hee Kang Yang Jae Yoo Jihye Je Beom Jae Lee Ji Hoon Kim Yeon Seok Seo Hyung Joon Yim Kwan Soo Byun 
AIM: To evaluate the inflammasome activation and the effect of peroxisome proliferator-activated receptors(PPAR)-δ agonist treatment in nonalcoholic fatty liver disease(NAFLD) models.METHODS: Male C57BL/6J mice were ...
关键词：NONALCOHOLIC FATTY liver disease NONALCOHOLIC stea 
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