ANTI-EPILEPTIC

作品数:13被引量:18H指数:2
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相关领域:医药卫生更多>>
相关作者:吉永华更多>>
相关机构:上海大学中国科学院上海生命科学研究院更多>>
相关期刊:《Asian Pacific Journal of Tropical Biomedicine》《Neuroscience & Medicine》《Neural Regeneration Research》《Open Journal of Psychiatry》更多>>
相关基金:国家自然科学基金更多>>
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Anti-epileptic and Neuroprotective Effects of Ultra-low Dose NADPH Oxidase Inhibitor Dextromethorphan on Kainic Acid-induced Chronic Temporal Lobe Epilepsy in Rats被引量:2
《Neuroscience Bulletin》2024年第5期577-593,共17页Jing-Jing Yang Ying-Xin Liu Yan-Fang Wang Bi-Ying Ge Ying Wang Qing-Shan Wang Sheng Li Jian-Jie Zhang Ling-Ling Jin Jau-Shyong Hong Sheng-Ming Yin Jie Zhao 
supported by the National Major Scientific and Technological Special Project for Significant New Drugs Development(2019zx09301102);the Project of Liaoning Provincial Department of Education(LJKZ0826);the Open Project of National and Local Joint Engineering Research Center for Drug Research and Development of Neurodegenerative Diseases(2022GCYJZX-YB02).
Neuroinflammation mediated by microglia and oxidative stress play pivotal roles in the development of chronic temporal lobe epilepsy(TLE).We postulated that kainic acid(KA)-Induced status epilepticus triggers microgli...
关键词:Temporal lobe epilepsy DEXTROMETHORPHAN NADPH oxidase Ultra-low dose 
Knowledge about the Management of Anti-Epileptic Drug Treatment among General Practitioners in Brazzaville, Congo
《Neuroscience & Medicine》2023年第2期9-28,共20页Josué Euberma Diatewa Inès Frédérique Nsondé-Mondzié Dinah Happhia Boubayi Motoula-Latou Eliot Prince Galiéni Sounga-Banzouzi Yacouba Kaba Ghislain Armel Mpandzou Paul Macaire Ossou-Nguiet 
Background: Epilepsy is a chronic brain disorder. It often leads to disabilities and handicaps. In Africa, epilepsy is almost exclusively treated by general practitioners (GPs) because of a shortage of epilepsy specia...
关键词:EPILEPSY Drug Treatment General Practitioners KNOWLEDGE BRAZZAVILLE 
Risk of Autism Spectrum Disorder According to the Dose and Trimester of Exposure to Antiseizure Medications: A Systematic Review and Meta-Analysis
《Open Journal of Psychiatry》2023年第2期106-121,共16页Zakaria Ahmed Mohamed Erick Thokerunga Ali Omar Jimale Zhichen Liu Jingyi Fan 
Background: The association between prenatal exposure to antiseizure medications (ASM) and autism spectrum disorder has been documented. This study sought to examine and synthesize evidence from studies that have eval...
关键词:AUTISM Anti-Seizure ANTICONVULSANTS ANTI-EPILEPTIC Fetal PRENATAL 
ROS-removing nano-medicine for navigating inflammatory microenvironment to enhance anti-epileptic therapy被引量:2
《Acta Pharmaceutica Sinica B》2023年第3期1246-1261,共16页Zheng Zhou Keying Li Yongchao Chu Chao Li Tongyu Zhang Peixin Liu Tao Sun Chen Jiang 
support from the National Natural Science Foundation of China (81872808,82121002);Key Projects of Shanghai Science Founation (19JC1410800,China);Shanghai Municipal Science and Technology Major Project(2018SHZDZX01,China);ZJLab
As a neurological disorder in the brain,epilepsy is not only associated with abnormal synchronized discharging of neurons,but also inseparable from non-neuronal elements in the altered microenvironment.Anti-epileptic ...
关键词:EPILEPSY Polymeric micelle Reactive oxygen species Inflammation GLIOSIS NEUROPROTECTION 
Time to Reconsider Routine Timely Anti-epileptic Medication: Raising Hope with a “Smart” Nanoengineered System
《Neuroscience Bulletin》2022年第8期973-975,共3页Yingying Tang Jianan Quan Weijie Zhou Haoliang Zhou 
Despite the substantial advances achieved in the development of anti-epileptic treatments,pharmacotherapy is still the optimal choice for patients with epilepsy(PWEs)[1].Once diagnosed,PWEs are required by clinicians ...
关键词:epileptic ROUTINE EPILEPSY 
Pro-and anti-epileptic roles of microglia被引量:10
《Neural Regeneration Research》2021年第7期1369-1371,共3页Shinichi Kinoshita Ryuta Koyama 
supported in part by a Grant-in-Aid for Scientific Research (B)(17H03988 to RK) from JSPS and JST PRESTO (JPMJPR18H4 to RK)。
Microglia are brain-resident immune cells that contribute to the maintenance of brain homeostasis.In the epileptic brain, microglia show various activation phenotypes depending on the stage of epileptogenesis.Therefor...
关键词:EPILEPSY EPILEPTOGENESIS inflammatory cytokines MICROGLIA NEUROGENESIS neuron-microglia interaction SEIZURE 
Stigma and epilepsy in onchocerciasisendemic regions in Africa:a review and recommendations from the onchocerciasisassociated epilepsy working group被引量:1
《Infectious Diseases of Poverty》2019年第3期21-31,共11页Sarah O'Neill Julia Irani Joseph Nelson Siewe Fodjo Denis Nono Catherine Abbo Yasuaki Sato Augustine Mugarura Housseini Dolo Maya Ronse Alfred K.Njamnshi Robert Colebunders 
RC received funding from the European Research Council(grant No.ERCPoC 768815);VUR UOS and Jansen pharm aceuticals for organising the workshop,SO received funding at the Unit of Medical Anthropology,Department of Public Health,Institute of Tropical Medicine Antwerp from the Flemish Ministry of Sciences and Innovation in Belgium(grant No.SOFI 2014-2017).
Background:In onchocerciasis-endemic areas,particularly in those with a sub-optimal onchocerciasis control programme,a high prevalence of epilepsy is observed.Both onchocerciasis and epilepsy are stigmatizing conditio...
关键词:EPILEPSY ONCHOCERCIASIS Stigma Anti-epileptic treatment Nodding syndrome Discrimination Misconception Africa 
Electroencephalographic Findings after Eslicarbazepine Therapy in Focal Epileptic Syndrome Patients
《World Journal of Neuroscience》2018年第3期342-349,共8页Gabriel Salazar Marta Fragoso Javier Codas 
The efficacy and the tolerance of the AEDs have been extensibly studied in the past, however the effects of them on the EEG activity of epileptic patients have been scarcely studied. Eslicarbazepine is a third generat...
关键词:EEG FOCAL EPILEPSY ANTI-EPILEPTIC DRUGS 
Anti-epileptic effect of morin against experimental pentylenetetrazol-induced seizures via modulating brain monoamines and oxidative stress
《Asian Pacific Journal of Tropical Biomedicine》2018年第7期352-359,共8页Amit D.Kandhare Anwesha A.Mukherjee Subhash L.Bodhankar 
Objective: To evaluate the protective effect of morin against pentylenetetrazol(PTZ)-induced tonic-clonic convulsions in mice. Methods: Swiss albino mice(18-22 g) was used to induce convulsions by intraperitoneal(i.p....
关键词:Brain GABA Epilepsy MORIN Nitric oxide PENTYLENETETRAZOL Oxidative stress Xanthine oxidase 
Anti-Epileptic Drug Prescription in a Psychiatric Hospital Outpatient Clinic in Southeast Nigeria
《Open Journal of Psychiatry》2017年第4期294-306,共13页Justin U. Achor Emeka C. Nwefoh Birinus A. Ezeala-Adikaibe Chinwe F. S. Ezeruigbo Aham O. Agomoh 
The optimum control of seizures requires adequate dosing of appropriately selected anti-epileptic medications. The availability of AEDs in Nigeria is limited and this constrains the prescription latitude of clinicians...
关键词:EPILEPSY Treatment ANTI-EPILEPTIC Drug PRESCRIBING PSYCHIATRIC NIGERIA 
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