supported by the National Major Scientific and Technological Special Project for Significant New Drugs Development(2019zx09301102);the Project of Liaoning Provincial Department of Education(LJKZ0826);the Open Project of National and Local Joint Engineering Research Center for Drug Research and Development of Neurodegenerative Diseases(2022GCYJZX-YB02).
Neuroinflammation mediated by microglia and oxidative stress play pivotal roles in the development of chronic temporal lobe epilepsy(TLE).We postulated that kainic acid(KA)-Induced status epilepticus triggers microgli...
Background: Epilepsy is a chronic brain disorder. It often leads to disabilities and handicaps. In Africa, epilepsy is almost exclusively treated by general practitioners (GPs) because of a shortage of epilepsy specia...
Background: The association between prenatal exposure to antiseizure medications (ASM) and autism spectrum disorder has been documented. This study sought to examine and synthesize evidence from studies that have eval...
support from the National Natural Science Foundation of China (81872808,82121002);Key Projects of Shanghai Science Founation (19JC1410800,China);Shanghai Municipal Science and Technology Major Project(2018SHZDZX01,China);ZJLab
As a neurological disorder in the brain,epilepsy is not only associated with abnormal synchronized discharging of neurons,but also inseparable from non-neuronal elements in the altered microenvironment.Anti-epileptic ...
Despite the substantial advances achieved in the development of anti-epileptic treatments,pharmacotherapy is still the optimal choice for patients with epilepsy(PWEs)[1].Once diagnosed,PWEs are required by clinicians ...
supported in part by a Grant-in-Aid for Scientific Research (B)(17H03988 to RK) from JSPS and JST PRESTO (JPMJPR18H4 to RK)。
Microglia are brain-resident immune cells that contribute to the maintenance of brain homeostasis.In the epileptic brain, microglia show various activation phenotypes depending on the stage of epileptogenesis.Therefor...
RC received funding from the European Research Council(grant No.ERCPoC 768815);VUR UOS and Jansen pharm aceuticals for organising the workshop,SO received funding at the Unit of Medical Anthropology,Department of Public Health,Institute of Tropical Medicine Antwerp from the Flemish Ministry of Sciences and Innovation in Belgium(grant No.SOFI 2014-2017).
Background:In onchocerciasis-endemic areas,particularly in those with a sub-optimal onchocerciasis control programme,a high prevalence of epilepsy is observed.Both onchocerciasis and epilepsy are stigmatizing conditio...
The efficacy and the tolerance of the AEDs have been extensibly studied in the past, however the effects of them on the EEG activity of epileptic patients have been scarcely studied. Eslicarbazepine is a third generat...
Objective: To evaluate the protective effect of morin against pentylenetetrazol(PTZ)-induced tonic-clonic convulsions in mice. Methods: Swiss albino mice(18-22 g) was used to induce convulsions by intraperitoneal(i.p....
The optimum control of seizures requires adequate dosing of appropriately selected anti-epileptic medications. The availability of AEDs in Nigeria is limited and this constrains the prescription latitude of clinicians...