supported by 1RO1EY032959-01 and RO1 supplement from NIH,Schuellein Chair Endowment Fund and STEM Catalyst Grant from the University of Dayton(to AS).
Acetyltransferases,required to transfer an acetyl group on protein are highly conserved proteins that play a crucial role in development and disease.Protein acetylation is a common post-translational modification pivo...
This work was supported by the National Key Basic Research and Development Program of China(2013 CB127802).
Histone lysine acetylation is catalyzed by acetyltransferases(HATs), which is important in regulating gene expression and physiological function in eukaryotic cells. HATs can be classified into two main types: A-and B...
Supported by the National Natural Science Foundation of China(No.30972991);Research Projects of the PLA General Logistics Department,China(No.BWS12J077 and No.BKJ16J010)
Objective: To investigate the effect of a modi?ed Wuzi Yanzong Pill(五子衍宗丸, WZYZP) on the male rats' testis after microwave radiation, as well as its potential mechanism. Methods: Forty-?ve male rats were randomly...
The altered function of any epigenetic modification also causally affects the physiological homeostasis in different pathophysiological conditions such as cancer,neurodegenerative disorders,diabetes,asthma,COPD etc.Am...
Supported by Xiamen Science and Technology Key Program Plan Grant(No.3502Z20100006);Scientific Research Starting Foundation for New Teacher of Xiamen University(No.ZK1014)
OBJECTIVE: To study the effects of berberine on ac- tivity and mRNA expression of N-acetyltransferase in human lung cancer cell line A549. METHODS: N-acetyltransferase antibodies wereprepared. The human lung cancer ...
Supported by The National Institute of Alcohol Abuse and Alcoholism (R21 AA015683) awarded to P.L.T.
Although the clinical manifestations of alcoholic liver disease are well-described, little is known about the molecular basis of liver injury. Recent studies have indicated that ethanol exposure induces global protein...
AIM: To investigate the possible association of hereditary polymorphism of N-acetyltransferase 2 (NAT2) gene with the susceptibility towards senile dementia in farmer population of Shanghai suburb. METHODS: NAT2 gene ...
Cell cycle progression is regulated by interactions between cyclins and cyclin-dependent kinases (CDKs). p21(WAF1) is one of the CIP/KIP family which inhibits CDKs activity. Increased expression of p21(WAF1) may play ...