云南高校图书馆联盟文献共享服务平台- SPHINGOSINE

SPHINGOSINE: 作品数：80被引量：236H指数：8; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：张翼肖琼尹大力徐美林王菁更多>>; 相关机构：北京协和医学院首都医科大学天津市胸科医院天津医科大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金广东省自然科学基金北京市自然科学基金国家重点基础研究发展计划更多>>

Sphingosine kinase 1 knockout alleviates hepatic ischemia/reperfusion injury by attenuating inflammation and oxidative stress in mice被引量：4: 《Hepatobiliary & Pancreatic Diseases International》2019年第3期255-265,共11页Guang-Hui Qiang Zhong-Xia Wang An-Lai Ji Jun-Yi Wu Yin Cao Guang Zhang Yi-Yang Zhang Chun-Ping Jiang; supported by grants from the National Natural Science Foundation of China(81572393 and 81602093);the Natural Science Foundation of Jiangsu Province(BK20160118);the Key Projects supported by Medical Science and Technology Develop-ment Foundation,Nanjing Municipality Health Bureau(ZKX15020 and ZKX17022);Fundamental Research Funds for the Central Universities(021414380215,020414380080 and 021414380329); Background: Hepatic ischemia/reperfusion(I/R) injury remains a significant problem in clinical practice. Sphingosine kinase 1(Sph K1) phosphorylates sphingosine to sphingosine-1-phosphate(S1 P) which participates in m...; 关键词：ISCHEMIA/REPERFUSION injury SPHINGOSINE KINASE 1 INFLAMMATION Oxidative stress

p38 mitogen-activated protein kinase regulates type-Ⅰ vs type-Ⅱ phenotyping of human vascular endothelial cells被引量：1: 《World Journal of Translational Medicine》2015年第3期101-112,共12页Masako Nakahara Miwako Nishio Koichi Saeki Akira Yuo Kumiko Saeki; Supported by A Grant-in-Aid from the Ministry of Health;Labour and Welfare of Japan;No.KHD1017;by that from JST;PRESTO; AIM: To identify kinases involved in phenotype regulation of vascular endothelial cells(VECs): Proproliferative G-protein signaling 5(RGS5)^(high)(typeⅠ) vs anti-proliferative RGS5^(low)(typeⅡ) VECs.METHODS: Proteom...; 关键词：VASCULAR endothelial CELLS VASCULAR smooth muscle CELLS proteomic KINASE assay p38αmitogenactivated protein KINASE regulator of G-PROTEIN signaling 5 sphingosine-1-phosphate N-cadherin

Inhibition of sphingosine kinase 1 ameliorates acute liver failure by reducing high-mobility group box 1 cytoplasmic translocation in liver cells被引量：6: 《World Journal of Gastroenterology》2015年第46期13055-13063,共9页Yan-Chang Lei Ling-Ling Yang Wen Li Pan Luo Pei-Fen Zheng; Supported by the National Natural Science Foundation of China;No.81160065; AIM: To determine the therapeutic potential of sphingosine kinase 1(Sphk1) inhibition and its underlying mechanism in a well-characterized mouse model of D-galactosamine(D-Gal N)/lipopolysaccharide(LPS)-induced acute ...; 关键词：Acute liver failure SPHINGOSINE KINASE 1 High-mobi

Sphingosine kinase 1 dependent protein kinase C-δ activation plays an important role in acute liver failure in mice被引量：1: 《World Journal of Gastroenterology》2015年第48期13438-13446,共9页Yan-Chang Lei Ling-Ling Yang Wen Li Pan Luo; Supported by The National Natural Science Foundation of China;No.81160065; AIM: To investigate the role of protein kinase C(PKC)-δ activation in the pathogenesis of acute liver failure(ALF) in a well-characterized mouse model of D-galactosamine(D-Gal N)/lipopolysaccharide(LPS)-induced ALF.M...; 关键词：ACUTE liver failure Protein KINASE C-δ SPHINGOSINE KINASE 1 NUCLEAR factor-κB

鞘氨醇激酶1和核因子-κBp65在非小细胞肺癌组织中的表达及与预后的关系被引量：1: 《天津医药》2014年第4期305-308,共4页畅昶徐美林王菁; 目的探讨鞘氨醇激酶1(SPHK1)和核因子(NF)-κB在非小细胞肺癌(NSCLC)组织中的表达及其与NSCLC浸润、转移和预后的关系。方法选取93例外科手术切除并经常规组织学检查确诊为NSCLC的标本和癌旁正常的余肺组织,应用免疫组化SP法,一抗分别...; 关键词：癌非小细胞肺免疫组织化学预后鞘氨醇激酶1 非小细胞肺癌 SPHINGOSINE KINASE 1

Role of sphingosine kinases and sphingosine 1-phosphate in mediating adipogenesis: 《Journal of Diabetes Mellitus》2013年第2期52-61,共10页Lucy D. Mastrandrea; Recent Background: Development of obesity involves promotion of preadipocyte differrentiation. This study investigated the role that sphingosine kinases (SPHK) and ceramide-derived sphingosine 1-phosphate (S1P) play i...; 关键词：ADIPOCYTE ADIPOGENESIS Obesity SPHINGOSINE KINASE 3T3-L1 Cells SPHINGOSINE 1-Phosphate SPHINGOSINE 1-Phosphate Receptor

Sphingolipids in cardiovascular and cerebrovascular systems:Pathological implications and potential therapeutic targets: 《World Journal of Cardiology》2013年第4期75-86,共12页Masahito Kawabori Rachid Kacimi Joel S Karliner Midori A Yenari; Supported by Grants from the National Institutes of Health (NS40516,to Yenari MA);the Veteran's Merit Award(Yenari MA);the Uehara Foundation(2013 Research Fellowship,to Kawabori M);the National Heart,Lung,and Blood Institute/NHLBI(1P01 HL 68738 and R01 HL 090606 to Karliner JS);Grants to Yenari MA and Karliner JS were administered by the Northern California Institute for Research and Education;supported by resources of the Veterans Affairs Medical Center, San Francisco,California; The sphingolipid metabolites ceramide,sphingosine,and sphingosine-1-phosphate(S1P) and its enzyme sphingosine kinase(SphK) play an important role in the regulation of cell proliferation,survival,inflammation,and cell ...; 关键词：SPHINGOLIPIDS Sphingosine-1-phosphate SPHINGOSINE KINASE CERAMIDE KINASE

Sphk1 Expression and Survival Outcomes in Squamous Cell Carcinoma of the Oral Cavity: 《Journal of Cancer Therapy》2013年第3期704-708,共5页Brianna N. Harris Rizwan Masood Uttam K. Sinha; Sphingosine kinase 1 (SphK1) is an important mediator of apoptosis and the proliferation of cancer cells. It is upregulated in cells showing increasing radioresistance. Here we present the correlation between SphK1 ex...; 关键词：SPHINGOSINE KINASE 1 SQUAMOUS Cell CARCINOMA Radiation SPHINGOLIPIDS ORAL Cavity

Roles of sphingosine 1-phosphate on tumorigenesis被引量：5: 《World Journal of Biological Chemistry》2011年第2期25-34,共10页Hsinyu Lee; Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid with a variety of biological activities.It is generated from the conversion of ceramide to sphingosine by ceramidase and the subsequent conversion of sphingosi...; 关键词：SPHINGOSINE 1-phosphate SPHINGOSINE KINASE CERAMIDE ANGIOGENESIS Autophagy TUMORIGENESIS

Role of sphingosine kinase and sphingosine-1-phosphate in inflammatory arthritis被引量：3: 《World Journal of Biological Chemistry》2010年第11期321-326,共6页Alirio J Melendez Bernard P Leung; The importance of sphingosine kinase(SphK)and sphingosine-1-phosphate(S1P)in inflammation has been extensively demonstrated.As an intracellular second messenger,S1P plays an important role in calcium signaling and mob...; 关键词：CYTOKINES Inflammation RHEUMATOID ARTHRITIS SPHINGOSINE KINASE Sphingosine-1-phosphate

SPHINGOSINE