PARKINSONS

作品数：206被引量：380H指数：9
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相关领域：医药卫生生物学更多>>
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相关机构：辽东学院安徽医科大学广州中医药大学中山大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金国家高技术研究发展计划更多>>
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Controversies and insights into PTBP1-related astrocyte-neuron transdifferentiation:neuronal regeneration strategies for Parkinson’s and Alzheimer’s disease
《Translational Neurodegeneration》2024年第1期184-199,共16页Simon McDowall Vaishali Bagda Stuart Hodgetts Frank Mastaglia Dunhui Li 
funded by Bryant Stokes Neurological Research Fund,FightMND Drug Development Grant,and Channel 7 Telethon research grant.
Promising therapeutic strategies are being explored to replace or regenerate the neuronal populations that are lost in patients with neurodegenerative disorders.Several research groups have attempted direct reprogramm...
关键词：Neuronal regeneration Astrocyte-neuron reprogramming Astrocyte heterogeneity Therapeutic strategies 
Replacing what’s lost: a new era of stem cell therapy for Parkinson’s disease被引量：4
《Translational Neurodegeneration》2020年第1期10-19,共10页Yong Fan Winanto Shi-Yan Ng 
This work is supported by the Third Affiliated Hospital of Guangzhou Medical University;as well as partially supported by National Medical Research Council(Singapore):NMRC/OFYIRG/2016/11.
Background Stem cells hold tremendous promise for regenerative medicine because they can be expanded infinitely,giving rise to large numbers of differentiated cells required for transplantation.Stem cells can be deriv...
关键词：Parkinson’s disease Induced PLURIPOTENT stem cells Cell therapy REGENERATIVE medicine 
Effectiveness and safety of opicapone in Parkinson’s disease patients with motor fluctuations: the OPTIPARK open-label study被引量：1
《Translational Neurodegeneration》2020年第1期96-104,共9页Heinz Reichmann Andrew Lees José-Francisco Rocha Diogo Magalhaes Patrício Soares-da-Silva the OPTIPARK investigators 
The study was funded by BIAL;Three authors(JFR,DM and PSS)were employed by the funder and participated in the study design,data collection,data management,and data analysis;The funder of the study had no other role in data interpretation or in the decision to submit the manuscript for publication;BIAL also supported reporting of study results by procuring medical writing support.
Background:The efficacy and safety of opicapone,a once-daily catechol-O-methyltransferase inhibitor,have been established in two large randomized,placebo-controlled,multinational pivotal trials.Still,clinical evidence...
关键词：LEVODOPA Motor FLUCTUATIONS OPEN-LABEL Opicapone Parkinson’s disease 
δ-secretase in neurodegenerative diseases: mechanisms, regulators and therapeutic opportunities被引量：4
《Translational Neurodegeneration》2020年第1期1-9,共9页Zhentao Zhang Ye Tian Keqiang Ye 
This work is supported by grants from the National Institute of Health(RF1,AG051538,RO1,NS105982)to K.Ye;grants from the National Natural Science Foundation of China(No.81822016,81771382,and 81571249)to Z.Zhang.
Mammalian asparagine endopeptidase(AEP)is a cysteine protease that cleaves its protein substrates on the Cterminal side of asparagine residues.Converging lines of evidence indicate that AEP may be involved in the path...
关键词：AEP Alzheimer’s DISEASE Parkinson’s DISEASE C/EBPΒ TrkB TDP-43 
Suppression of astrocytic autophagy by αB-crystallin contributes to α-synuclein inclusion formation被引量：6
《Translational Neurodegeneration》2019年第1期24-37,共14页Shen-zhao Lu Yong-shun Guo Pei-zhou Liang Shu-zhen Zhang Shu Yin Yan-qing Yin Xiao-min Wang Fei Ding Xiao-song Gu Jia-wei Zhou 
This work was supported by grants from the Natural Science Foundation of China(31430036,91742116,U1801681);National Key Basic Research Program of China(2015CB553500);Key Research Program of Frontier Sciences(QYZDJ-SSW-SMC002);Strategic Priority Research Program of Chinese Academy of Science(XDB32020100);Shanghai Municipal Science and Technology Major Project(2018SHZDZX05);the Shanghai Municipal Science and Technology Commission(17ZR1435300 to SZZ).
Background:Parkinson’s disease(PD)is characterized by a chronic loss of dopaminergic neurons and the presence of proteinaceous inclusions(Lewy bodies)within some remaining neurons in the substantia nigra.Recently,ast...
关键词：αB-crystallin ASTROCYTES Parkinson’s disease AUTOPHAGY 
Cognitive characteristics in Chinese non-demented PD patients based on gender difference被引量：2
《Translational Neurodegeneration》2018年第1期145-153,共9页Ke Yang Bo Shen Da-ke Li Ying Wang Jue Zhao Jian Zhao Wen-Bo Yu Zhen-yang Liu Yi-lin Tang Feng-tao Liu Huan Yu Jian Wang Qi-hao Guo Jian-jun Wu 
This work was supported by grants 81571232 and 81371413 from the National Natural Science Foundation of China(to Jian Wang);grant 81301136 from the National Natural Science Foundation of China(to Huan Yu);Project 2016YFC1306500 from Ministry of Science and technology of China(to Jian Wang);project XBR20134042 from Shanghai Municipal Health Bureau(to Huan Yu);Grant form Jingan District JA2015-Z002(to Jian-jun Wu).
Background:Cognitive impairment is one of the non-motor symptoms in Parkinson’s disease(PD).In the present study,we aim to examine the cognitive function of non-demented Parkinson’s disease patients and compare the ...
关键词：Parkinson’s DISEASE COGNITION GENDER effect COGNITIVE deficits 
Objective assessment of bradykinesia in Parkinson’s disease using evolutionary algorithms:clinical validation被引量：3
《Translational Neurodegeneration》2018年第1期167-174,共8页Chao Gao Stephen Smith Michael Lones Stuart Jamieson Jane Alty Jeremy Cosgrove Pingchen Zhang Jin Liu Yimeng Chen Juanjuan Du Shishuang Cui Haiyan Zhou Shengdi Chen 
This work was supported by the National Natural Science Foundation of China(grant numbers.81430022,81771374).
Background:There is an urgent need for developing objective,effective and convenient measurements to help clinicians accurately identify bradykinesia.The purpose of this study is to evaluate the accuracy of an objecti...
关键词：Parkinson’s DISEASE BRADYKINESIA EVOLUTIONARY algorithms Objective assessment CLINICAL validation 
Dopaminergic neurons show increased low-molecular-mass protein 7 activity induced by 6-hydroxydopamine in vitro and in vivo
《Translational Neurodegeneration》2018年第1期175-186,共12页Ming-Shu Mo Gui-Hua Li Cong-Cong Sun Shu-Xuan Huang Lei Wei Li-Min Zhang Miao-Miao Zhou Zhuo-Hua Wu Wen-Yuan Guo Xin-Ling Yang Chao-Jun Chen Shao-Gang Qu Jian-Xing He Ping-Yi Xu 
This work was supported by research grants from National Key R&D Program of China(2016YFC1306600,SQ2017YFSF110116);National Natural Science Foundation of China(81701254,81471292,U1603281,U1503222,81430021,81501100,NO.8187050204);Science Foundation of Guangdong of China(2015A030311021,2018A030313649);a technology project of Guangzhou(201504281820463);Shandong Provincial Natural Science Foundation(BS2015YY041);International Project of Science and Technology for Guangdong(2016A050502025);Science and Technology of Guangdong of China(2013B022000026);Collaborative Innovation Foundation of Guangzhou Science and Technology Bureau(2018-1202-SF-0019).
Background:Abnormal expression of major histocompatibility complex class I(MHC-I)is increased in dopaminergic(DA)neurons in the substantia nigra(SN)in Parkinson’s disease(PD).Low-molecular-mass protein 7(β5i)is a pr...
关键词：Parkinson’s disease 6-HYDROXYDOPAMINE IMMUNOPROTEASOME TAP1 
CSF Aβ1-42 level is associated with cognitive decline in early Parkinson’s disease with rapid eye movement sleep behavior disorder被引量：3
《Translational Neurodegeneration》2018年第1期212-220,共9页Maowen Ba Guoping Yu Min Kong Hui Liang Ling Yu 
This Study was funded by Chinese National Natural Science Foundation(No.81571234);Key research and development plan of Shandong Province(2018GSF118235);Shandong Province medical science and technology development projects(2014WS0260);Yantai Science and Technology Development Project(2014WS035,2016WS037).
Background:Rapid eye movement sleep behavior disorder(RBD)is associated with cognitive decline in early Parkinson’s disease(PD).However,the underlyling basis for this association remains unclear.Methods:Parkinson’s ...
关键词：Parkinson’s disease Rapid eye movement sleep behavior disorder Cognitive DECLINE Β-AMYLOID 
AGE-induced neuronal cell death is enhanced in G2019S LRRK2 mutation with increased RAGE expression被引量：3
《Translational Neurodegeneration》2018年第1期1-8,共8页Hyun Jin Cho Chengsong Xie Huaibin Cai 
This work was supported by the intramural research programs of National Institute on Aging,National Institutes of Health(HC:AG000944).
Background:Leucine-rich repeat kinase 2(LRRK2)mutations represent the most common genetic cause of sporadic and familial Parkinson’s disease(PD).Especially,LRRK2 G2019S missense mutation has been identified as the mo...
关键词：Parkinson’s disease LRRK2 G2019S AGE RAGE NEURONAL DEATH 
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