SKELETAL

作品数：348被引量：493H指数：10
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相关领域：医药卫生更多>>
相关作者：周婷婷李惠怡雷勇华李静先李晖更多>>
相关机构：第二军医大学重庆医科大学中南大学天津运动医学研究所更多>>
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相关基金：国家自然科学基金北京市自然科学基金国家重点基础研究发展计划中国博士后科学基金更多>>
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Multimodal analyses of immune cells during bone repair identify macrophages as a therapeutic target in musculoskeletal trauma
《Bone Research》2024年第4期818-831,共14页Yasmine Hachemi Simon Perrin Maria Ethel Anais Julien Julia Vettese Blandine Geisler Christian Göritz Céline Colnot 
supported by National Institute of Arthritis and Musculoskeletal and Skin Diseases R01 AR072707 (C.C.and Ted Miclau)and R01 AR081671 (C.C.and Ralph Marcucio);Agence Nationale de la Recherche ANR-18-CE14-0033 and ANR-21-CE18-007-01 (C.C.)。
Musculoskeletal traumatic injuries(MTI)involve soft tissue lesions adjacent to a bone fracture leading to fibrous nonunion.The impact of MTI on the inflammatory response to fracture and on the immunomodulation of skel...
关键词：SKELETAL HEALING TRAUMA 
Schnurri-3 inhibition rescues skeletal fragility and vascular skeletal stem cell niche pathology in the OIM model of osteogenesis imperfecta
《Bone Research》2024年第3期675-688,共14页Na Li Baohong Shi Zan Li Jie Han Jun Sun Haitao Huang Alisha R.Yallowitz Seoyeon Bok Shuang Xiao Zuoxing Wu Yu Chen Yan Xu Tian Qin Rui Huang Haiping Zheng Rong Shen Lin Meng Matthew B.Greenblatt Ren Xu 
supported by the National Natural Science Foundation of China (81972034,92068104 and 82002262 to R.X.);the National Key R&D Program of China (2020YFA0112900 to R.X.);Project of Xiamen Cell Therapy Research Center (3502Z20214001 to R.X.);supported by a the NIH grant of US (R01AR075585,R01HD115274,R01CA282815 to M.B.G.);Career Award for Medical Scientists from the Burroughs Wellcome Fund;a Pershing Square Sohn Cancer Research Alliance and the Maximizing Innovation in Neuroscience Discovery (MIND)Prize;supported by a Jump Start Research Career Development Award from Weill Cornell Medicine;a Study Abroad Scholarships from the Mogam Science Scholarship Foundation。
Osteogenesis imperfecta(OI)is a disorder of low bone mass and increased fracture risk due to a range of genetic variants that prominently include mutations in genes encoding typeⅠcollagen.While it is well known that ...
关键词：SKELETAL imperfect ENDOTHELIUM 
Osteoclasts control endochondral ossification via regulating acetyl-CoA availability
《Bone Research》2024年第3期720-733,共14页Daizhao Deng Xianming Liu Wenlan Huang Sirui Yuan Genming Liu Shanshan Ai Yijie Fu Haokun Xu Xinyi Zhang Shihai Li Song Xu Xiaochun Bai Yue Zhang 
supported by Grant Nos.31872799,82070906 and 31701033 from the National Natural Science Foundation of China;Grant Nos.2020A1515011189 from Guangdong Basic and Applied Basic Research Foundation of China。
Osteoclast is critical in skeletal development and fracture healing,yet the impact and underlying mechanisms of their metabolic state on these processes remain unclear.Here,by using osteoclast-specific small GTPase Rh...
关键词：HEALING SKELETAL CATHEPSIN 
Metabolic reprogramming in skeletal cell differentiation
《Bone Research》2024年第3期539-554,共16页Joshua C.Bertels Guangxu He Fanxin Long 
partly supported by NIH grant R01DK125498 (FL)。
The human skeleton is a multifunctional organ made up of multiple cell types working in concert to maintain bone and mineral homeostasis and to perform critical mechanical and endocrine functions.From the beginning st...
关键词：FUNCTIONS SKELETON PROGRAMMING 
PCLAF induces bone marrow adipocyte senescence and contributes to skeletal aging
《Bone Research》2024年第3期595-610,共16页Lingqi Xie Yalun Cheng Biao Hu Xin Chen Yuze An Zhuying Xia Guangping Cai Changjun Li Hui Peng 
supported by the National Key R&D Program of China (2021YFC2501702);the National Natural Science Foundation of China,China (grant nos.82270911,82201746,82000848,82300998);the National Key Research and Development Plan (2022YFC3601900,2022YFC3601901,2022YFC3601902,2022YFC3601903,2022YFC3601904,and 2022YFC3601905);the Key Research and Development Program of Hunan Province,China (2022WK2010)。
Bone marrow adipocytes(BMAds)affect bone homeostasis,but the mechanism remains unclear.Here,we showed that exercise inhibited PCNA clamp-associated factor(PCLAF)secretion from the bone marrow macrophages to inhibit BM...
关键词：SKELETAL inhibited HOMEOSTASIS 
Skeletal interoception in osteoarthritis
《Bone Research》2024年第2期241-254,共14页Dinglong Yang Jiawen Xu Ke Xu Peng Xu 
supported by the National Natural Science Foundation of China(82072432).
The interoception maintains proper physiological conditions and metabolic homeostasis by releasing regulatory signals after perceving changes in the internal state of the organism.Among its various forms,skeletal inte...
关键词：HOMEOSTASIS INFLAMMATION RELEASING 
Pannexins in the musculoskeletal system:new targets for development and disease progression被引量：1
《Bone Research》2024年第2期255-269,共15页Yan Luo Shengyuan Zheng Wenfeng Xiao Hang Zhang Yusheng Li 
supported by National Key R&D Program of China(2019YFA0111900,2023YFB4606705);National Natural Science Foundation of China(No.82072506,82272611,92268115,82302764);Hunan Provincial Science Fund for Distinguished Young Scholars(No.2024JJ2089);Science and Technology Innovation Program of Hunan Province(No.2021RC3025,2023SK2024);Provincial Natural Science Foundation of Hunan(No.2022JJ70162,2023JJ30949);National Clinical Research Center for Geriatric Disorders(Xiangya Hospital,Grant No.2021KFJJ02 and 2021LNJJ05);National Clinical Research Center for Orthopedics,Sports Medicine and Rehabilitation(2021-NCRC-CXJJ-PY-40).
During cell differentiation,growth,and development,cells can respond to extracellular stimuli through communication channels.Pannexin(Panx)family and connexin(Cx)family are two important types of channel-forming prote...
关键词：SKELETAL DISEASES SYSTEM 
The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair
《Bone Research》2024年第2期289-301,共13页Heeseog Kang Amy L.Strong Yuxiao Sun Lei Guo Conan Juan Alec C.Bancroft Ji Hae Choi Chase A.Pagani Aysel A.Fernandes Michael Woodard Juhoon Lee Sowmya Ramesh Aaron W.James David Hudson Kevin N.Dalby Lin Xu Robert J.Tower Benjamin Levi 
supported by NIH R01 AR078324 and R01 AR071379.
While hypoxic signaling has been shown to play a role in many cellular processes,its role in metabolism-linked extracellular matrix(ECM)organization and downstream processes of cell fate after musculoskeletal injury r...
关键词：METABOLISM SKELETAL ABERRANT 
Brain regulates weight bearing bone through PGE2 skeletal interoception: implication of ankle osteoarthritis and pain被引量：2
《Bone Research》2024年第1期107-121,共15页Feng Gao Qimiao Hu Wenwei Chen Jilong Li Cheng Qi Yiwen Yan Cheng Qian Mei Wan James Ficke Junying Zheng Xu Cao 
This research was supported by NIH National Institute on Aging under Award Number R01 AG076783,R01 AG068997 and P01 AG066603(to X.C.).
Bone is a mechanosensitive tissue and undergoes constant remodeling to adapt to the mechanical loading environment.However,it is unclear whether the signals of bone cells in response to mechanical stress are processed...
关键词：PAIN ELEVATED PGE2 
Age-related secretion of grancalcin by macrophages induces skeletal stem/progenitor cell senescence during fracture healing
《Bone Research》2024年第1期122-136,共15页Nan-Yu Zou Ran Liu Mei Huang Yu-Rui Jiao Jie Wei Yangzi Jiang Wen-Zhen He Min Huang Yi-Li Xu Ling Liu Yu-Chen Sun Mi Yang Qi Guo Yan Huang Tian Su Ye Xiao Wei-Shan Wang Chao Zeng Guang-Hua Lei Xiang-Hang Luo Chang-Jun Li 
This work was supported by the National Key R&D Program of China(Project No.2019YFA0111900 to C.J.L.and Y.J.,2022YFC3601900 to G.H.L.,2022YFC3601903 to X.H.L.,and 2022YFC3601905);the National Natural Science Foundation of China(Grant Nos.82261160397,82272560,81922017 to C.J.L.and 81930022,91749105 to X.H.L.);the NSFC/RGC Joint Research Scheme,the Research Grants Council(UGC)of the Hong Kong Special Administrative Region and the National Natural Science Foundation of China(NSFC/RGC Project No.N_CUHK483/22 to Y.J.);the Hunan Provincial Science and Technology Department(2023JJ30896 to C.J.L.);the Key Research and Development Program of Hunan Province(2022SK2023 to C.J.L.);the Science and Technology Innovation Program of Hunan Province(2023RC1027 to C.J.L.,2022RC1009 to J.W,and 2022RC3075 to C.Z.).
Skeletal stem/progenitor cell(SSPC)senescence is a major cause of decreased bone regenerative potential with aging,but the causes of SSPC senescence remain unclear.In this study,we revealed that macrophages in calluse...
关键词：healing UNION SENESCENCE 
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