Aliphatic C-H groups are among the most abundant yet least reactive functional groups in organic molecules.Nature has evolved metalloenzymes such as those of the cytochrome P450 superfamily that efficiently activate i...
National Key Research and Development Program of China(2022YFC3401502 to X-H.F.,2023YFA1800603 to Y-G.C.);National Natural Science Foundation of China(U21A20356 and 32321002 to X-H.F.,31988101 to Y-G.C.);Zhejiang Provincial Natural Science Foundation(LD21C070001 to X-H.F.,LZ22C070001 to S.G.);Fundamental Research Funds for the Central Universities。
The family of secreted dimeric proteins known as the Transforming Growth Factor-β(TGF-β)family plays a critical role in facilitating intercellular communication within multicellular animals.A recent symposium on TGF...
OBJECTIVE To investigate whether aldo-keto reductases(AKRs)can act as a nitrore⁃ductase(NR)and bioactivate aristolochic acidⅠ(AA-Ⅰ)to produce AA-Ⅰ-DNA adducts.METHODS①Human-induced hepatocytes(hiHeps)and human bla...
supported by the National Key Research and Development Program of China(Grant Nos.2021YFF1001201 and 2022YFF1001601-4);Key Research and Development Program of Shandong Province(Grant Nos.2023LZGC008 and 2021LZGC003);the National Scientific and Technological Innovation 2030-Major Project(Grant No.2023ZD040360102);the Joint Funds of the National Natural Science Foundation of China(Grant No.U1906203);the National Transgenic Project of China(Grant Nos.2016ZX08010002-009 and 2018ZX08009-14B);Taishan Scholar Youth Project of Shandong Province(Grant No.tsqn202306072);Young Scientists Fund of the National Natural Science Foundation of China(Grant No.32301876);Natural Science Foundation of Shandong Province Youth Fund(Grant No.ZR2023QC180);Qingdao Natural Science Foundation(Grant No.23-2-1-38-zyyd-jch);Shandong University Qilu Young Scholar。
The development of flowers in soybean(Glycine max)is essential for determining the yield potential of the plant.Gene silencing pathways are involved in modulating flower development,but their full elucidation is still...
Fund for Scientific Research(FNRS)PDR T0236.20;FNRS-Exellence of Science 30913351;FNRS CDR J.0175.23(to FT)。
Microtubules play a central role in cytoskeletal changes during neuronal development and maintenance.Microtubule dynamics is essential to polarity and shape transitions underlying neural cell division,differentiation,...
supported by the National Natural Science Foundation of China(Grant Nos.32201516,91954202);the Youth Top-notch Talent Program of Hebei Education Department(BJK2022028);National Training Program of Innovation and Entrepreneurship for Undergraduates(Grant Nos.S202110022037,G202010022075);the funding of Hebei North University(XJ2021013)。
The nuclear-encoded factors and the photosynthetic apparatus have been studied extensively during chloroplast biogenesis.However,many questions regarding these processes remain unanswered,particularly in perennial woo...
Complex proteins are needed for many biological activities.Folding amino acid chains reveals their properties and functions.They support healthy tissue structure,physiology,and homeostasis.Precision medicine and treat...
Proteins are essential for many biological functions.For example,folding amino acid chains reveals their functionalities by maintaining tissue structure,physiology,and homeostasis.Note that quantifiable protein charac...
This study was supported by the National Natural Science Foundation of China(No.32000231,31970316,32170274,31770329 and 32070327);Program of Shanghai Academic Research Leader(19XD1405000);Shanghai Sail Program(19YF1459300)。
Objective AP2/ERF(APETALA2/ethylene-responsive factor)superfamily is one of the largest gene families in plants and has been reported to participate in various biological processes,such as the regulation of biosynthes...
This work was financially supported by the National Natural Science Foundation of China(No.31771103);Chinese Academy of Sciences(CAS)Emergency Project of African Swine Fever(ASF)Research(No.KJZD-SW-L07);the Scientific Instrument Developing Project of the CAS(No.YJKYYQ20190057).
Cell membrane integrity is fundamental to the normal activities of cells and is involved in both acute and chronic pathologies.Here,we report a probe for analyzing cell membrane integrity developed from a 9 nm-sized p...