TARGETED

作品数：1083被引量：3093H指数：24
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  • 期刊=Signal Transduction and Targeted Therapyx
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TransTACs:novel heterobispecific antibodies for targeted protein degradation in cancer therapy
《Signal Transduction and Targeted Therapy》2024年第12期5370-5372,共3页Wolfgang Walther Sebastian Torke Ulrike Stein 
In a recent article in Nature,Dingpeng Zhang and colleagues1 describe a novel approach for the degradation of target proteins.Their newly designed heterobispecific antibody modality hijacks the transferrin receptor in...
关键词：CANCER MODALITY ANTIBODIES 
Targeted protein degradation:advances in drug discovery and clinical practice
《Signal Transduction and Targeted Therapy》2024年第12期5386-5430,共45页Guangcai Zhong Xiaoyu Chang Weilin Xie Xiangxiang Zhou 
supported by National Natural Science Foundation(No.82170189,No.81800194);Translational Research Grant of NCRCH(No.2020ZKMB01);Shandong Provincial Natural Science Foundation(ZR2021YQ51);Technology Development Project of Jinan City(No.202134034);Taishan Scholars Program of Shandong Province;Shandong Provincial Engineering Research Center of Lymphoma;Academic Promotion Programme of Shandong First Medical University(No.2020RC006).
Targeted protein degradation(TPD)represents a revolutionary therapeutic strategy in disease management,providing a stark contrast to traditional therapeutic approaches like small molecule inhibitors that primarily foc...
关键词：OVERCOME eliminate RATIONAL 
Epigenetics-targeted drugs:current paradigms and future challenges
《Signal Transduction and Targeted Therapy》2024年第12期5539-5609,共71页Wanlin Dai Xinbo Qiao Yuanyuan Fang Renhao Guo Peng Bai Shuang Liu Tingting Li Yutao Jiang Shuang Wei Zhijing Na Xue Xiao Da Li 
supported by the National Natural Science Foundation grant of China(No.82371647,82071607,82071651,82403489);National Key Research and Development Program(2022YFC3600304,2022YFC2704700);Science and Technology Department of Sichuan Province(23ZDYF2489);Cadre Health Care Committee of Sichuan Province,China(2023-1701);Chengdu Science and Technology Bureau(2021-YF05-02106-SN,2017-GH02-00030-HZ);Outstanding Scientific Fund of Shengjing Hospital(No.202003);Sichuan University 0-1 Innovation Research project(2023SCUH0019);The Frontiers Medical Center,Tianfu Jincheng Laboratory Foundation(T FJC2023010001);China Postdoctoral Science Foundation(No.2023M733902,2023M743909);PHD Research Initiated Fund Project in Liaoning Province(No.2023-BSBA-331,2023-BSBA-352);Science and Technology Plan of Liaoning Province(2022JH2/20200066);345 Talent Project of Shengjing Hospital of China Medical University(No.M1344).
Epigenetics governs a chromatin state regulatory system through five key mechanisms:DNA modification,histone modification,RNA modification,chromatin remodeling,and non-coding RNA regulation.These mechanisms and their ...
关键词：DRUGS TARGETED offering 
Signaling pathways involved in colorectal cancer:pathogenesis and targeted therapy
《Signal Transduction and Targeted Therapy》2024年第11期4856-4903,共48页Qing Li Shan Geng Hao Luo Wei Wang Ya-Qi Mo Qing Luo Lu Wang Guan-Bin Song Jian-Peng Sheng Bo Xu 
supported by the National Natural Science Foundation of China(82203066,to Q.L.);the Chongqing Natural Science Foundation(2024NSCQMSX3327,to Q.L.);the National Natural Science Foundation of China(61906022,to B.X.);Chongqing University Research Fund 2021CDJXKJC004.
Colorectal cancer(CRC)remains one of the leading causes of cancer-related mortality worldwide.Its complexity is influenced by various signal transduction networks that govern cellular proliferation,survival,differenti...
关键词：PATHOGENESIS TARGETED COLORECTAL 
Genetically programmable cell membrane-camouflaged nanoparticles for targeted combination therapy of colorectal cancer被引量：1
《Signal Transduction and Targeted Therapy》2024年第7期2999-3014,共16页Yun Yang Qingya Liu Meng Wang Lang Li Yan Yu Meng Pan Danrong Hu Bingyang Chu Ying Qu Zhiyong Qian 
supported by the National Natural Science Foundation of China(NSFC82202320,NSFC31930067,and NSFC U21A2041);the Natural Science Foundation of Sichuan Province(2023NSFSC1585);the 135 Project for Disciplines of Excellence,West China Hospital,Sichuan University(ZYGD18002,China);the Post-Doctor Research Project,West China Hospital,Sichuan University(No.19HXBH099,China).
Cell membrane-camouflaged nanoparticles possess inherent advantages derived from their membrane structure and surface antigens,including prolonged circulation in the bloodstream,specific cell recognition and targeting...
关键词：CD47 COLORECTAL cancer 
Engineered extracellular vesicles for targeted reprogramming of cancer-associated fibroblasts to potentiate therapy of pancreatic cancer被引量：1
《Signal Transduction and Targeted Therapy》2024年第7期3077-3096,共20页Pengcheng Zhou Xuanlong Du Weilu Jia Kun Feng Yewei Zhang 
supported by National Major Scientific Research Instrument Development Project:62227803;the Key Program of the National Natural Science Foundation of China:62331016;National Natural Science Foundation of China:62141109;the Leading-edge Technology Programme of Jiangsu Natural Science Foundation:BK20212012;Key Research and Development Plan Project of Jiangsu Province:BE2022812.
Pancreatic cancer is one of the deadly malignancies with a significant mortality rate and there are currently few therapeutic options for it.The tumor microenvironment(TME)in pancreatic cancer,distinguished by fibrosi...
关键词：inhibited TARGETED CHEMOTHERAPY 
Optimizing oncolytic virus design:a“Swiss army knife”approach to create a systemically delivered therapeutic
《Signal Transduction and Targeted Therapy》2024年第5期1791-1792,共2页Carolina S.Ilkow John Cameron Bell 
C.S.I.and J.C.B.are supported by the Canadian Cancer Society Research Institute(CCSRI)and the Canadian Institutes of Health Research(CIHR).
In a recent paper published in Nature Biotechnology,Chen et al.1 describe a multiplex oncolytic virus platform that coupled with adoptive T cell therapy could solve the problem of repeat,systemic delivery of virus bas...
关键词：THERAPEUTIC al. TARGETED 
RNA modifications in cellular metabolism:implications for metabolism-targeted therapy and immunotherapy被引量：1
《Signal Transduction and Targeted Therapy》2024年第4期1565-1594,共30页Wei-Wei Liu Si-Qing Zheng Tian Li Yun-Fei Fei Chen Wang Shuang Zhang Fei Wang Guan-Min Jiang Hao Wang 
supported by the Scientific Research Project of Anhui Provincial Education Department (2022AH020079);the Natural Science Foundation of Anhui Province (2008085MH241).
Cellular metabolism is an intricate network satisfying bioenergetic and biosynthesis requirements of cells.Relevant studies have been constantly making inroads in our understanding of pathophysiology,and inspiring dev...
关键词：METABOLISM TARGETED alterations 
From signalling pathways to targeted therapies: unravelling glioblastoma’s secrets and harnessing two decades of progress被引量：1
《Signal Transduction and Targeted Therapy》2023年第11期5270-5302,共33页Brittany Dewdney Misty RJenkins Sarah ABest Saskia Freytag Krishneel Prasad Jeff Holst Raelene Endersby Terrance GJohns 
S.A.B.is supported by a Victorian Cancer Agency Mid-Career Research Fellowship(MCRF22003);S.F.is supported by a National Health and Medical Research Council of Australia(NHMRC)Ideas Grant(GNT1184421);R.E.has support from a Cancer Council of Western Australia Research Fellowship and a Brainchild Fellowship from the Pirate Ship Foundation;This work was supported in part through M.RJ,S.A.B.,K.P.,R.E.and,S.F.membership of the Brain Cancer Centre;K.P.is supported by an Australian Government Research Training Program Scholarship and the Ann Henderson PhD Scholarship。
Glioblastoma,a rare,and highly lethal form of brain cancer,poses significant challenges in terms of therapeutic resistance,and poor survival rates for both adult and paediatric patients alike.Despite advancements in b...
关键词：GLIOBLASTOMA THERAPIES TARGETED 
Hedgehog signaling in tissue homeostasis, cancers, and targeted therapies被引量：8
《Signal Transduction and Targeted Therapy》2023年第9期4082-4114,共33页Junjun Jing Zhuoxuan Wu Jiahe Wang Guowen Luo Hengyi Lin Yi Fan Chenchen Zhou 
This work was supported by NSFC grants 82222015,82171001 and 81800928;Young Elite Scientist Sponsorship Program by CAST No.2020QNRC001;Research Funding from West China School/Hospital of Stomatology Sichuan University RCDWJS2023-(1).
The past decade has seen significant advances in our understanding of Hedgehog(HH)signaling pathway in various biological events.HH signaling pathway exerts its biological effects through a complex signaling cascade i...
关键词：HOMEOSTASIS THERAPIES TARGETED 
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