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作品数：1877被引量：2864H指数：19
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Modular,Scalable Total Synthesis of Neopetromin
《Chinese Journal of Chemistry》2024年第23期3023-3028,共6页Hiroshige Ogawa Yuuya Nagata Hugh Nakamura 
Financial support for this work was provided by a grant from the RGC of the Hong Kong SAR,China(ECS,HKUST 26302024);start-up funds from HKUST(Project No.R9820)to H.N;This work was partly supported by JSPS KAKENHI Grant Number JP23H03810,JST-ERATO(JPMJER1903);the Institute for Chemical Reaction Design and Discovery(ICReDD),which was established by the World Premier International Research Initiative(WPI),MEXT,Japan(Y.N.);The computation was partly performed using Research Center for Computational Science,Okazaki,Japan(Project:23-IMS-C119,Y.N.).
The first total synthesis of neopetromin,featuring the highly strained Tyr C-6-to-Trp N-1’linkage,is hereby reported.This modular synthetic strategy,employing C—H arylation and Larock macrocyclization,offers a novel...
关键词：Total synthesis Natural product Biaryl cyclic peptides RiPPs C-H activation Larock macrocyclization Scalable synthesis 
Total Synthesis of Syringin and Its Natural Analogues via C—C Bond Activation of Aryl Ketones被引量：1
《Chinese Journal of Chemistry》2023年第24期3587-3592,共6页Zhen-Yu Wang Yi Sun Guo-Dong Sun Hui Xu Hui-Xiong Dai 
supported by the Shanghai Institute of Materia Medica,the Chinese Academy of Sciences,the National Natural Science Foundation of China(21772211,21920102003);the Institutes for Drug Discovery and Development,Chinese Academy of Sciences(CASIMM0120163006);the Science and Technology Commission of Shanghai Miunicipality(17JC1405000,18431907100);the Program of Shanghai Academic Research Leader(19xD1424600);the National Science&Technology Major Project"Key New Drug Creation and Manufacturing Program",China(2018ZX09711002-006).
Syringin is found in the root of Acanthopanax senticosus(Rupr.Maxim.)Harms and belongs to the lignin chemical compound with many biological activities.In this study,we employed commercially available starting material...
关键词：SYRINGIN Total synthesis CROSS-COUPLING C—C activation Syringin analogues 
Total Synthesis of UCS1025A via Tandem Carbonylative Stille Cross Coupling and Diels-Alder Reactiont被引量：1
《Chinese Journal of Chemistry》2023年第22期3019-3024,共6页Chengsen Cui Mingi Dai 
supported by NSF 2102022.
We report an efficient and convergent strategy for the total synthesis of UCS1025A and its diastereomer tetra-epi-UCS1025A.Ucs1025A is a representative member of the naturally occurring pyrrolizidinone polyketides,fro...
关键词：Natural products Total synthesis UCS1025A CARBONYLATION Diels-Alder reaction Tandem reaction 
Concise Total Synthesis of Dysoxylactam A and a Simplified Analog
《Chinese Journal of Chemistry》2022年第17期2027-2034,共8页Guan-Zhou Yang Lei Wang Yao-Yue Fan Zeng-Wei Lai Xue-Ni Yu Li-Guang Lou Kun Gao Jian-Min Yue 
support from the National Natural Science Foundation of China(Nos.81861138045,22177121);the CAMS Innovation Fund forMedical Sciences(2019-12M-5-080);the Biological Resources Program,CAS(KFJ-BRP-008-001)of People's Republicof China isgratefully acknowledged;support of Science and Technology Commission of Shanghai Municipality(20ZR1467800).
A total synthesis of 17-membered macrocyclolipopeptide dysoxylactam A,a potent agent reversing P-glycoprotein(P-gp)-mediated multidrug resistance(MDR)in cancer cells,was developed from the starting material(S)-2-methy...
关键词：Total synthesis Dysoxylactam A Macrocyclolipopeptide Reversing multidrug resistance Structure-activity relationship 
Total Synthesis of Nucleoside Antibiotics Amicetin,Plicacetin,and Cytosaminomycin A-D被引量：1
《Chinese Journal of Chemistry》2021年第10期2679-2684,共6页Jiqiang Fu Peng Xu Biao Yu 
the National Natural Science Foundation of China(Nos.21861162011,22031011,&21621002);the National Key Research&Development Program of China(No.2018YFA0507602);the Key Research Program of Frontier Sciencesof CAS(No.ZDBS-LY-SLH030);the Strategic Priority Research Program of CAS(No.XDB20020000);the Youth Innovation Promotion Association of CAS(No.2020258)are acknowledged.
Main observation and conclusion Amicetin and congeners constitute a small family of complex pyrimidine nucleosides,which exhibit strong antibiotic activities against Gram-positive bacteria and notably against strains ...
关键词：Total synthesis GLYCOSYLATION NUCLEOSIDE Amicetin Cytosaminomycin 
Protecting-Group-Free Total Synthesis of(-)-Pallambins A-D被引量：1
《Chinese Journal of Chemistry》2021年第7期1983-1996,共14页Xiwu Zhang Yuan Wang Peng Chen Xinxian Cai Yanxing Jia 
This research was supported by the National Natural Science Foundation of China(Nos.21925101 and 21572008).
Main observation and conclusion A full account of the total synthesis of(-)-pallambins A-D(1-6)is described.The strategy was devised by simulating their biosynthetic pathway.The left-part bicyclo[3.2.1]octane system o...
关键词：TERPENOIDS Total synthesis ENANTIOSELECTIVITY Protecting-Group-Free Natural products 
Rhodium(Ⅱ)-Catalyzed [4+3] Cyclization of Triazoles with Indole Derivatives and Its Application in the Total Synthesis of (±)-Aurantioclavine被引量：1
《Chinese Journal of Chemistry》2021年第5期1145-1152,共8页Shengguo Duan Bing Xue Hui Meng Zihang Ye Ze-Feng Xu Chuan-Ying Li 
the National Natural Science Foundation of China(Nos.21871235,21901230,21801224);the Natural Science Foundation of Zhejiang Province(No.LQ18B020009);the Fundamental Research Funds of Zhejiang Sci-Tech University(2019Y003);the Science Foundation of Zhejiang Sci-Tech University(ZSTU)under Grant No.18062301-Y is gratefully acknowledged.
An efficient rhodium(Ⅱ)-catalyzed[4+3]cyclization reaction of 1-sulfonyl-1,2-3-triazoles and indoles was developed.Azepino[5,4,3-ccflindoles,which are widely distributed in ergot alkaloids with various biological act...
关键词：TRIAZOLES RHODIUM ALKALOIDS CYCLIZATION Aurantioclavine 
Modular Total Synthesis of (-)-Palmyrolide A and (+)-(5S,7S)-Palmyrolide A via Ring-Closing Metathesis and Alkene Isomerization被引量：1
《Chinese Journal of Chemistry》2021年第1期69-74,共6页Yecai Lai Wei-Min Dai 
This work is supported in part by a General Research Fund grant(601211)from the Research Grant Council;The Hong Kong Special Administrative Region,P.R.China;The Hong Kong Chiu Chow Chamber of Commence HKUST Scholarship for Ph.D.Study(Y.L.);the Department of Chemistry,HKUST.
A pentamodule assembly approach has been established for total synthesis of the naturally occurring(-)-palmyrolide A and(+)-5,7-epi-palmyrolide A.By using the racemic tert-butyl carbinol-containing alkyl iodide,the tw...
关键词：ALKENE B-Alky Suzuki-Miyaura cross-coupling Modular total synthesis Cross coupling Ring-closing metathesis 
Palladium-Catalzyed Atroposelective 16-Membered Macrocyclization: Total Synthesis of lsoplagiochin D
《Chinese Journal of Chemistry》2020年第10期1081-1085,共5页Junwei Xi Zhenhua Gu 
This work was financially supported by the National Natural Science Foundation of China(No.21871241);the Fundamental Research Funds for the Central Universities(WK2060190086).
Summary of main observation and conclusion Isoplagiochin D is a ring-strained macrocyclic bisbibenzylis,which showed stable axial chirality in one biaryl structure,and semistable axial chirality in the other biaryl mo...
关键词：CYCLIZATION BENZYL CATALYZED 
The [4+2] Cycloaddition of 2-Pyrone in Total Synthesis被引量：4
《Chinese Journal of Chemistry》2019年第9期946-976,共31页Quan Cai 
The National Natural Science Foundation of China (Grant No. 21801043), the "Z1000-Youth Talents Plan", and Fudan University (start-up gra nt) are ack no wledged for fi nan cial support.
Diels-Alder reaction is one of the most important reactions in organic synthesis and has witnessed great achievements in total syntheses of complex natural products.In this review,we will focus on the [4+2] cycloaddit...
关键词：CYCLOADDITION 2-Pyrone TOTAL SYNTHESIS 
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