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作品数：84被引量：182H指数：7
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相关领域：生物学农业科学更多>>
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相关机构：中国农业大学南京工业大学香港科技大学江南大学更多>>
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Aberrant outputs of cerebellar nuclei and targeted rescue of social deficits in an autism mouse model
《Protein & Cell》2024年第12期872-888,共17页Xin-Yu Cai Xin-Tai Wang Jing-Wen Guo Fang-Xiao Xu Kuang-Yi Ma Zhao-Xiang Wang Yue Zhao Wei Xie Martijn Schonewille Chris De Zeeuw Wei Chen Ying Shen 
supported by grants from the STI2030-Major Projects (2021ZD0204000);Key Strategic Science and Technology Cooperation Project (2023YFE0206800) of the Ministry of Science and Technology of China;the National Natural Science Foundation of China (81625006, 31820103005, 32000692);Zhejiang Province Natural Science Foundation of China (LZ24C090003 and LY21C090003);the Science and Technology Programme of Hangzhou Municipaility (20190101A10);the Key Realm R&D Program of Guangdong Province (2019B030335001);the Netherlands Organization for Scientific Research (NWO-ALW 824.02.001);the Dutch Organization for Medical Sciences (Zon MW 91120067);Medical Neuro-Delta (MD 01092019-31082023);INTENSE LSH-NWO (TTW/00798883);ERC-adv (GA-294775);ERC-POC (737619 and 768914)
The cerebellum is heavily connected with other brain regions,sub-serving not only motor but also nonmotor functions.Genetic mutations leading to cerebellar dysfunction are associated with mental diseases,but cerebella...
关键词：CEREBELLUM THALAMUS MIDBRAIN large-scale tracing AUTISM 
Safe transportation and targeted destruction:Albumin encapsulated aggregation-induced emission photosensitizer nanoaggregate for tumor photodynamic therapy through mitochondria damage-triggered pyroptosis
《Aggregate》2024年第6期379-391,共13页Juanmei Cao Yong Qu Shaojie Zhu Jinshan Zhan Yiting Xu Yifan Jin Yuqing Wang Zhuoxia Li Chuxing Chai Xiangwei Wu Meng Gao Changzheng Huang Min Li 
National Natural Science Foundation of China,Grant/Award Numbers:82172754,22175065,81972565,81874208;Xinjiang Production and Construction Corps,Grant/Award Number:2023ZD023。
Photodynamic therapy is a highly recommended alternative treatment for solid tumors,such as cutaneous or luminal tumors,in clinical practice.However,conventional photosensitizers(PSs)often induce undesirable phototoxi...
关键词：aggregation-induced emission gasdermin E mitochondria damage nanoparticle albumin-bound photodynamic therapy PYROPTOSIS 
Integrating proteomics and targeted metabolomics to reveal the material basis of liver-gallbladder damp-heat syndrome in chronic hepatitis B
《Digital Chinese Medicine》2024年第4期320-331,共12页LI Ni’ao GONG Yuefeng WANG Jia CHEN Qingqing SU Shibing ZHANG Hua LU Yiyu 
National Natural Science Foundation of China(82274183);Shanghai Municipal Health Commission’s special clinical research project in the health industry(202240243);Science and Technology Innovation Program of Science and Technology Commission of Shanghai Municipality(STCSM)(20ZR1453700).
Objective To elucidate the biological basis of liver-gallbladder damp-heat syndrome(LGDHS)within the framework of traditional Chinese medicine(TCM)as a complementary diagnostic and therapeutic approach in chronic hepa...
关键词：Liver-gallbladder damp-heat syndrome(LGDHS) Chronic hepatitis B(CHB) PROTEOMICS Targeted metabolomics Molecular mechanism Biomarkers 
Adenosine signaling in tumor-associated macrophages and targeting adenosine signaling for cancer therapy
《Cancer Biology & Medicine》2024年第11期995-1011,共17页Lei Yang Yi Zhang Li Yang 
supported by grants from the State’s Key Project of Research and Development Plan(Grant No.2021YFE0110600);the National Natural Science Foundation of China(Grant Nos.82072578 and 82350121);the Funding for Scientific Research and Innovation Team of The First Affiliated Hospital of Zhengzhou University(Grant No.ZYCXTD2023013)。
This review examined the critical role of adenosine signaling in modulating the behavior of tumor-associated macrophages(TAMs),a key determinant of the tumor microenvironment(TME).Adenosine is an immunosuppressive met...
关键词：Adenosine signaling CD39 CD73 tumor associated macrophages cancer therapy 
Discovery of potent anti-MRSA components from Dalbergia odorifera through UPLC-Q-TOF-MS and targeting PBP2a protein through in-depth transcriptomic,in vitro,and in-silico studies
《Journal of Pharmaceutical Analysis》2024年第8期1251-1254,共4页Jiajia Wu Syed Shams ul Hassan Xue Zhang Tao Li Abdur Rehman Shikai Yan Huizi Jin 
the National Natural Science Foundation of China(Grant No.:81973191);Shanghai Agriculture Applied Technology Development Program,China(Program No.:T20200104);the National Key Research and Development Program of China(Program No.:2018YFE0192600)for providing financial support for the complete undertaking.
Methicillin-resistant Staphylococcus aureus(MRSA)is an important pathogen casting dire shadow over global human wellbeing[1].Rising antibiotic resistance in MRSA led to research into plant-derived anti-microbial agent...
关键词：protective MRSA anti 
Enhancing sheepgrass through genomic exploration and targeted editing
《Science China(Life Sciences)》2024年第3期629-630,共2页Miao Sun Sanwen Huang Yao Zhou 
The growth of grass industry is essential for meeting human needs for proteins and sustaining grassland ecosystems(Bengtsson et al., 2019). Leymus chinensis, also known as sheepgrass, is a perennial Triticeae forage r...
关键词：GRASSLAND SHEEP ECOSYSTEMS 
The role of circRNAs and miRNAs in drug resistance and targeted therapy responses in breast cancer
《Cancer Drug Resistance》2024年第1期495-507,共13页Meilan Zhang Zhaokuan Zheng Shouliang Wang Ruihan Liu Mengli Zhang Zhiyun Guo Hao Wang Weige Tan 
supported by the Science and Technology Project of Guangzhou City(No.202201010029).
MicroRNAs(miRNAs)are small non-coding RNAs comprising 19-24 nucleotides that indirectly control gene expression.In contrast to other non-coding RNAs(ncRNAs),circular RNAs(circRNAs)are defined by their covalently close...
关键词：MIRNAS circRNAs breast cancer clinical values 
Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer被引量：5
《Genes & Diseases》2024年第1期218-233,共16页Zanwen Zuo Zerong Zhou Yuzhou Chang Yan Liu Yuping Shen Qizhang Li Lei Zhang 
supported by the Guiding Project of Science and Technology Research Program of the Hubei Provincial Department of Education(China)(No.B2020048);the Collaborative Grant-in-Aid of the HBUT National"111"CenterforCellular RegulationandMolecularPharmaceutics(China)(No.XBTK-2021006);the Open Project Funding of the Key Laboratory of Fermentation Engineering(Ministry of Education,China)(No.202105FE02);the Hubei University of Technology(China)(No.BSQD2020038).
Ribonucleotide reductase M2(RRM2)is a small subunit in ribonucleotide reduc-tases,which participate in nucleotide metabolism and catalyze the conversion of nucleotides to deoxynucleotides,maintaining the dNTP pools fo...
关键词：FUNCTION INHIBITION REGULATION Resistance RRM2 
Metagenomic and targeted metabolomic analyses reveal distinct phenotypes of the gut microbiota in patients with colorectal cancer and type 2 diabetes mellitus被引量：1
《Chinese Medical Journal》2023年第23期2847-2856,共10页Yong Yang Zihan Han Zhaoya Gao Jiajia Chen Can Song Jingxuan Xu Hanyang Wang An Huang Jingyi Shi Jin Gu 
National Natural Science Foundation(No.82073223);Beijing Natural Science Foundation(No.7224351)
Background:Type 2 diabetes mellitus(T2DM)is an independent risk factor for colorectal cancer(CRC),and the patients with CRC and T2DM have worse survival.The human gut microbiota(GM)is linked to the development of CRC ...
关键词：Bile acids Colorectal cancer Gut microbiota Short-chain fatty acids Type 2 diabetes mellitus 
Ru/Pt@BSA nanoparticles for efficient photo-catalytic oxidation of NAD(P)H and targeted cancer treatment under hypoxic conditions
《Chinese Chemical Letters》2023年第12期440-445,共6页Xuwen Da Xiulian Liu Chao Li Yatong Peng Yao Jian Wanpeng Zhou Yunli Xu Yao Wu Xuesong Wang Qianxiong Zhou 
financially supported by Research Equipment Development Project of Chinese Academy of Sciences(No.YJKYYQ20210014).
Photo-catalytic oxidation of intracellular nicotinamide adenine dinucleotide(2'-phosphate)(NAD(P)H)has attracted much attention for cancer therapy.However,the general oxygen-dependent mechanism heavily depresses the e...
关键词：HYPOXIC Cancer treatment Photo-catalytic oxidation NAD(P)H Cyclic utilization of oxygen Pt nanoparticle 
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