With the advances in medicine and technology,life expectancy has increased significantly in recent decades.While this is positive news,it also brings major challenges to public health systems.As people live longer,the...
Based on data from Global Burden of Disease,Injuries,and Risk Factors(2024),disorders of the central nervous system(CNS)are an important cause of death or long-term disability,representing the top-ranked contributor t...
Neurodegenerative diseases are often studied in isolation due to the vast differences in their underlying causes,the diversity in neuron types affected,and the variations in their clinical symptoms.However,there are c...
funded by a senior research fellowship from Alzheimer’s Research UK (ARUK-SRF2022A-005);funded by a PhD studentship from Alzheimer’s Society (571);supported by the UK Dementia Research Institute through UK DRI Ltd.;principally funded by the UK Medical Research Council
Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(ALS)are neurodegenerative diseases with significant overlapping attributes.While these neurod...
The immune system has been attracting increasing attention in the field of chronic neurological disorders in the central nervous system(CNS).Autoreactive T cells targeting CNS antigens play a crucial role in the devel...
supported by:Fondazione Telethon-Italy(No.GGP19128 to AP);Fondazione Cariplo-Italy(No.2021-1544 to RC);Fondazione Italiana di Ricerca per la Sclerosi Laterale Amiotrofica(AriSLA)-Italy(No.MLOpathy to AP;Target-RAN to AP);Association Française contre les Myopathies-France(AFM Telethon No.23236 to AP);Kennedy’s Disease Association-USA(2018 grant to RC;2020 grant to MG);Ministero dell’Universitàe della Ricerca(MIUR)-Italy(PRIN-Progetti di ricerca di interesse nazionale(No.2017F2A2C5 to AP;No.2022EFLFL8 to AP;No.2020PBS5MJ to VC;No.2022KSJZF5 to VC);PRIN-Progetti di ricerca di interesse nazionale-bando 2022,PNRR finanziato dall’Unione europea-Next Generation EU,componente M4C2,investimento 1.1(No.P2022B5J32 to RC and No.P20225R4Y5 to VC);CN3:RNA-Codice Proposta:CN_00000041;Tematica Sviluppo di terapia genica e farmaci con tecnologia a RNA(Centro Nazionale di Ricerca-CN3 National Center for Gene Therapy and Drugs based on RNA Technology to AP);Progetto Dipartimenti di Eccellenza(to DiSFeB);Ministero della Salute,Agenzia Italiana del Farmaco(AIFA)-Italy(Co_ALS to AP);Universitàdegli Studi di Milano(piano di sviluppo della ricerca(PSR)UNIMI-linea B(to RC and BT).
Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock proteins.HSPB8 is involved in various cellular mechanisms mainly related to prote...
funded by grants from the Spanish Ministry of Science,Innovation and Universities(Ref.PID2019-110356RB-I00/AEI/10.13039/501100011033)to JFI and ES;the Department of Economic and Business Development from Government of Navarra(Ref.0011-1411-2023-000028 to ES);supported by a predoctoral fellowship from the Public University of Navarra(UPNA);supported by a postdoctoral fellowship from Miguel Servet Foundation-Navarrabiomed;supported by“Programa MRR Investigo 2023”in the framework of the European Union recovery and resilience facility。
Data-driven drug repositioning using olfactory omics profiles-challenges and perspectives in neurodegeneration:Neurodegenerative diseases are characterized by progressive degeneration and loss of neuronal function in ...
supported by a grant from Aston University,Birmingham,UK (to DM)。
Myelin is the protective sheath surrounding nerve fibers, and its damage(demyelination) occurs in many central nervous system(CNS) diseases, including multiple sclerosis(MS), traumatic injury, neurodegenerative diseas...
supported by the NIH grant(RO1 NS118066);the Blazer Foundation(to XJL)。
Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower extre...
Neurodegenerative disorders such as Alzheimer's and Parkinson's diseases a re increasing in prevalence as world populations age.While tremendous progress has been made,our understanding of the mechanisms that underlie...