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HYPOTHESIS: 作品数：682被引量：721H指数：12; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：邱林林刘东生刘骏田东旭李瑶更多>>; 相关机构：云南大学西华师范大学内蒙古师范大学中国科学院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家社会科学基金中国博士后科学基金更多>>

Amyloid-βis NOT only the most promising target for Alzheimer’s disease: 《Neural Regeneration Research》2026年第2期681-682,共2页Beka Solomon Milana Voronov-Goldman; Amyloid-β(Aβ)and tau,the two hallmark proteins associated with Alzheimer’s disease(AD),exhibit distinct toxic effects but also interact synergistically within the disease pathology.The prevailing theory in AD patho...; 关键词：amyloid precursor protein app initially intracellular peptides amyloid cascade hypothesis amyloid cascade hypothesis highlights AMYLOID tau Alzheimers disease SECRETASE

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus: 《Neural Regeneration Research》2025年第6期1711-1712,共2页Haoqi Sun Shiqian Shen Robert J.Thomas M.Brandon Westover Can Zhang; supported by the Massachusetts General Hospital Scientific Projects to Accelerate Research and Collaboration (SPARC) award;Cure Alzheimer’s Fund (to CZ);the National Institutes of Health (NIH),including R01NS102190,RF1NS120947,and R01HL161253 (to MBW),RF1NS120947 (to RJT)。; Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primari...; 关键词：ALZHEIMER inflammation HYPOTHESIS

A"messenger zone hypothesis"based on the visual three-dimensional spatial distribution of motoneurons innervating deep limb muscles: 《Neural Regeneration Research》2024年第7期1559-1567,共9页Chen Huang Shen Wang Jin Deng Xinyi Gu Shuhang Guo Xiaofeng Yin; supported by the Chinese National General Program of the National Natural Science Foundation of China,No.82072162(to XY)。; Coordinated contraction of skeletal muscles relies on selective connections between the muscles and multiple classes of the spinal motoneuro ns.Howeve r,current research on the spatial location of the spinal motoneuro...; 关键词：3-D imaging MOTONEURONS multiple retrograde tracing muscle coordination skeletal muscle spatial distribution optical tissue clearing

Alzheimer’s disease risk after COVID-19:a view from the perspective of the infectious hypothesis of neurodegeneration: 《Neural Regeneration Research》2023年第7期1404-1410,共7页Eugenia Olivera Albany Sáez Lila Carniglia Carla Caruso Mercedes Lasaga Daniela Durand; supported by grants to DD from Agencia Nacional de Promoción de la Investigación,el desarrollo tecnológico y la innovación(ANPCyT,PICT N°03893).; In light of the rising evidence of the association between viral and bacterial infections and neurodegeneration,we aimed at revisiting the infectious hypothesis of Alzheimer’s disease and analyzing the possible impli...; 关键词：Alzheimer amyloid beta antimicrobial cognitive decline COVID-19 infectious hypothesis long-term sequelae NEURODEGENERATION NEUROINFLAMMATION neurological symptoms NEUROTROPISM SARS-CoV-2

Estrogen rapid effects:a window of opportunity for the aging brain?: 《Neural Regeneration Research》2022年第8期1629-1632,共4页Ivanny Marchant Jana Stojanova Lilian Acevedo Pablo Olivero; Estrogen produces several beneficial effects in healthy neurological tissues and exhibits cardioprotective effects.Hormone therapy has been widely used to treat menopausal estrogen deficiency for more than 80 years.De...; 关键词：AGING cardiovascular prevention cognitive function ESTROGEN hormone treatment INFLAMMAGING rapid effects timing hypothesis TRPV1 window of opportunity

Ultra-early amplitude decrement after repetitive nerve stimulation supports early neuromuscular junction injury in amyotrophic lateral sclerosis:a prospective cross-sectional study被引量：1: 《Neural Regeneration Research》2022年第3期655-660,共6页Jing-Yue Ma Xiang-Yi Liu Shuo Zhang Dong-Sheng Fan; The dying-back hypothesis holds that the damage to neuromuscular junctions and distal axons in amyotrophic lateral sclerosis occurs at the earliest stage of the disease.Previous basic studies have confirmed early dama...; 关键词：amplitude decremental response amyotrophic lateral sclerosis dying-back hypothesis motor neuron disease nerve electrophysiology PHYSIOPATHOLOGY prognosis repetitive nerve stimulation

Amyloid hypothesis through the lens of Aβ supersaturation: 《Neural Regeneration Research》2021年第8期1562-1563,共2页Zhefeng Guo; supported by the National Institute of Health,USA (No. R01AG050687)。; Deposition of aggregated amyloid-β(Aβ)protein in the form of amyloid plaques is a pathological hallmark of Alzheimer's disease.According to the amyloid hypothesis,Aβaggregation initiates a pathogenic cascade,eventu...; 关键词：AΒ AMYLOID ALZHEIMER

A different view on the pathophysiology of Parkinson’s disease:a descendent neurochemical hypothesis?: 《Neural Regeneration Research》2019年第10期1717-1718,共2页Burak Yulug Mehmet Ozansoy Seyda Cankaya; It has been already shown that Parkinson’s disease (PD) is characterized by a prominent degeneration in substantia nigra (SN) neurons. Growing evidence suggests that there is a latent period of PD associated with sli...; 关键词：PARKINSON period CAUSE has NEU PD is

What can computational modeling offer for studying the Ca^(2+) dysregulation in Alzheimer's disease:current research and future directions被引量：2: 《Neural Regeneration Research》2018年第7期1156-1158,共3页Jingyi Liang Don Kulasiri; Ca^2＋ dysregulation is an early event observed in Alzheimer＇s disease（AD） patients preceding the presence of its clinical symptoms.Dysregulation of neuronalCa^2＋ will cause synaptic loss and neuronal death,eventu...; 关键词：Alzheimer＇s disease amyloid-beta Ca^2＋ hypothesis Ca^2＋ dysregulation computational modeling computational neuroscience

Territory maximization hypothesis during peripheral nerve regeneration: 《Neural Regeneration Research》2018年第2期230-231,共2页jiu-xu deng jian weng yu-hui kou pei-xun zhang yan-hua wang na han bao-guo jiang xiao-feng yin; supported by grants from the National Program on Key Basic Rtesearch Project of China(973 Program),No.2014CB542200;the National Natural Science Foundation of China,No.31471144,31571002,31271284,31171150,81171146,30971526;a grant from Program for Innovative Research Team in University of Ministry of Education of China,No.IRT1201; Territory awareness refers to the notion that an organism lives in a territory, considers this territory its own, and prevents entry of other organisms. Generally, an organism maximizes its territory for best survival...; 关键词：Territory maximization hypothesis during peripheral nerve regeneration

HYPOTHESIS