supported by grants from the National Students’ Innovation and Entrepreneurship Training Program of China (No. 201810443009);Students’ Innovation and Entrepreneurship Training Program of Jining Medical University (No. cx2018005);A Project of Shandong Province Higher Educational Science and Technology Program (No. J18KA124);Supporting Fund for Teachers’ Research of Jining Medical University (No. JY2017KJ036, JY2017KJ034)