《World Journal of Stem Cells》

作品数：994被引量：2707H指数：21
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《World Journal of Stem Cells》
主办单位：百世登出版集团有限公司
最新期次：2025年4期更多>>
发文主题：STEMMESENCHYMALCELLSMESENCHYMAL_STEM_CELLCELL更多>>
发文领域：医药卫生生物学农业科学理学更多>>
发文基金：国家自然科学基金中国博士后科学基金北京市自然科学基金国家重点基础研究发展计划更多>>
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Mechanisms and challenges of mesenchymal stem cells in the treatment of knee osteoarthritis
《World Journal of Stem Cells》2025年第4期1-5,共5页Jing-Shun Lu Chen-Yu Song Wen-Jing Cheng Kai-Yang Wang 
In this editorial,we comment on the recent article by Xiao et al,focusing on their investigation into whether the therapeutic efficacy of serum-free human umbilical cord mesenchymal stem cells(MSCs)differs from that o...
关键词：Mesenchymal stem cells Knee osteoarthritis INFLAMMATION EXOSOME Biological materials 
Non-coding RNAs in adipose-derived stem cell exosomes:Mechanisms,therapeutic potential,and challenges in wound healing
《World Journal of Stem Cells》2025年第4期6-19,共14页Jian Rong Yao-Yao Li Xin Wang Jia-Ning Wang Mei Song 
Supported by the Intra-Hospital Project of No.940 Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation Army,No.2021yxky016.
The treatment of complex wounds presents a significant clinical challenge due to the limited availability of standardized therapeutic options.Adipose-derived stem cell exosomes(ADSC-Exos)are promising for their capabi...
关键词：Adipose-derived stem cell exosomes Wound healing MICRORNAS Long noncoding RNAs Circular RNAs 
Stem cell therapy for intervertebral disc degeneration:Clinical progress with exosomes and gene vectors
《World Journal of Stem Cells》2025年第4期20-35,共16页Zhi-Peng Li Han Li Yu-Hua Ruan Peng Wang Meng-Ting Zhu Wei-Ping Fu Rui-Bo Wang Xiao-Dong Tang Qi Zhang Sen-Li Li He Yin Cheng-Jin Li Yi-Gong Tian Rui-Ning Han Yao-Bin Wang Chang-Jiang Zhang 
Supported by Henan Province Key Research and Development Program,No.231111311000;Henan Provincial Science and Technology Research Project,No.232102310411;Henan Province Medical Science and Technology Key Project,No.LHGJ20220566 and No.LHGJ20240365;Henan Province Medical Education Research Project,No.WJLX2023079;and Zhengzhou Medical and Health Technology Innovation Guidance Program,No.2024YLZDJH022.
Intervertebral disc degeneration is a leading cause of lower back pain and is characterized by pathological processes such as nucleus pulposus cell apoptosis,extracellular matrix imbalance,and annulus fibrosus rupture...
关键词：EXOSOMES Extracellular matrix repair Gene vector system Hypoxic environment Intervertebral disc degeneration Mesenchymal stem cells Regenerative medicine Stem cell therapy 
Evaluating the efficacy of stem cells in treating severe dry eye disease
《World Journal of Stem Cells》2025年第4期36-47,共12页Lanxing Fu Lucia Pelosini Nick Kopsachilis Roberta Foti Fabiana D’Esposito Mutali Musa Alberto D’Amico Daniele Tognetto Caterina Gagliano Marco Zeppieri 
Dry eye disease(DED)is a multifactorial disorder that disturbs ocular surface equilibrium,considerably diminishing quality of life.Present therapies only offer symptomatic alleviation.Stem cell treatment,especially me...
关键词：Dry eye disease Stem cell therapy Mesenchymal stem cells Corneal regeneration EXOSOME CORNEA Clinical trials 
Exosomal miR-137-3p targets UBE3C to activate STAT3,promoting migration and differentiation into endometrial epithelial cell of human umbilical cord mesenchymal stem cells under hypoxia
《World Journal of Stem Cells》2025年第4期48-63,共16页Wan-Yu Zhang Si-Miao Liu Han-Bi Wang Cheng-Yan Deng 
Supported by the National High Level Hospital Clinical Research Funding,No.2022-PUMCH-B-080 and No.2022-PUMCH-C-064.
BACKGROUND Thin endometrium,leading cause of recurrent implantation failure and infertility,has been found to respond to exosomes.AIM To investigate the efficacy of exosomes in addressing the issue of thin endometrium...
关键词：Endometrial epithelial cells EXOSOMES miR-137-3p Ubiquitin protein ligase E3C Signal transducer and activator of transcription 3 Human umbilical cord mesenchymal stem cells 
RNA interference-mediated osteoprotegerin silencing increases the receptor activator of nuclear factor-kappa B ligand/osteoprotegerin ratio and promotes osteoclastogenesis
《World Journal of Stem Cells》2025年第4期64-78,共15页Song-Guan Wei Hui-Hong Chen Liu-Rong Xie Yuan Qin Yu-Ying Mai Lin-Hui Huang Hong-Bing Liao 
Supported by the National Natural Science Foundation of China,No.82160192;and Guangxi Science and Technology Program,No.2023AB23037.
BACKGROUND In vivo degradation of bone scaffolds is significantly influenced by osteoclast(OC)activity,which is orchestrated by the interplay between receptor activator of nuclear factor-kappa B ligand(RANKL)and osteo...
关键词：OSTEOPROTEGERIN Receptor activator of nuclear factor-kappa B ligand Bone marrow-derived mesenchymal stem cells RNA interference OSTEOCLAST Bone scaffold 
L-arginine from elder human mesenchymal stem cells induces angiogenesis and enhances therapeutic effects on ischemic heart diseases
《World Journal of Stem Cells》2025年第4期79-98,共20页Jian-Zhong Li Xu Zhan Hao-Bo Sun Chao Chi Guo-Fu Zhang Dong-Hui Liu Wen-Xi Zhang Li-Hua Sun Kai Kang 
Supported by the National Natural Science Foundation of China,No.82472147;the Key Research and Development Program of Heilongjiang Province of China,No.2023ZX06C04;the Open Fund of Key Laboratory of Hepatosplenic Surgery,Ministry of Education,Harbin,China,No.GPKF202402.
BACKGROUND Mesenchymal stem cell(MSC)-based therapy may be a future treatment for myocardial infarction(MI).However,few studies have assessed the therapeutic efficacy of adipose tissue-derived MSCs(ADSCs)obtained from...
关键词：Adipose tissue-derived mesenchymal stem cells Bone marrow-derived mesenchymal stem cells L-ARGININE METABOLIC ANGIOGENESIS AGING 
EZH2,via an association with KDM2B,modulates osteogenic differentiation of root apical papillary stem cells
《World Journal of Stem Cells》2025年第4期99-112,共14页Hui-Yue Xu Yan-Tong Wang Hao-Qing Yang Yang-Yang Cao Zhi-Peng Fan 
Supported by National Key Research and Development Program,No.2022YFA1104401;Beijing Natural Science Foundation,No.7222075;CAMS Innovation Fund for Medical Sciences,No.2019RU020;Innovation Research Team Project of Beijing Stomatological Hospital,No.CXTD202204.
BACKGROUND Stem cells from apical papilla(SCAPs)represent promising candidates for bone regenerative therapies due to their osteogenic potential.However,enhancing their differentiation capacity remains a critical chal...
关键词：Bioactive peptides Bone tissue engineering Enhancer of zeste homolog 2 OSTEOGENIC Apical papillary stem cell 
Human umbilical cord mesenchymal stem cell-derived exosomal miR-199a-3p inhibits the MAPK4/NF-κB signaling pathway to relieve osteoarthritis
《World Journal of Stem Cells》2025年第4期113-135,共23页Ling-Qiang Chen Sha Ma Juan Yu Da-Chen Zuo Zi-Jing Yin Fa-You Li Xia He Hai-Ting Peng Xiao-Qing Shi Wei-Juan Huang Qin Li Jing Wang 
Supported by Basic Research Plan of Yunnan Province,No.202201AT070059;National Natural Science Foundation of China,No.81760407;Science and Technology Talent and Platform Plan of Yunnan Provincial Department of Science and Technology,No.202205AC160066.
BACKGROUND There is currently no effective treatment for osteoarthritis(OA),which is the most common joint disorder leading to disability.Although human umbilical cord mesenchymal stem cells(hUC-MSCs)are promising OA ...
关键词：OSTEOARTHRITIS Human umbilical cord mesenchymal stem cells EXOSOMES MiR-199a-3p Mitogen-activated protein kinase 4 Nuclear factor-kappaB 
Effectiveness of mesenchymal stem cell-derived extracellular vesicles therapy for Parkinson’s disease:A systematic review of preclinical studies
《World Journal of Stem Cells》2025年第4期136-149,共14页Xue-Song Wang Yue Wang Yan Xu Shan-Rong Zhang Yang Zhang Lu-Lu Peng Nan Wu Jun-Song Ye 
Supported by the National Natural Science Foundation of China,No.32060232;and the Natural Science Foundation of Jiangxi Province,No.20212BAB206075.
BACKGROUND Mesenchymal stem cell-derived extracellular vesicles(MSC-EVs)can traverse the blood-brain barrier due to their small size.This characteristic makes them a research hotspot for the treatment of Parkinson’s ...
关键词：Mesenchymal stem cell Extracellular vesicles EXOSOMES Stem cell therapy Parkinson’s disease Systematic review 
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