《Bioactive Materials》

作品数：1911被引量：5108H指数：25
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《Bioactive Materials》
主办单位：中国科技出版传媒股份有限公司
最新期次：2024年12期更多>>
发文主题：HYDROGELTISSUE_ENGINEERINGWOUND_HEALINGSCAFFOLDBIODEGRADABLE更多>>
发文领域：医药卫生一般工业技术化学工程金属学及工艺更多>>
发文基金：国家自然科学基金中国博士后科学基金广东省自然科学基金北京市自然科学基金更多>>
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Neuroprotection on ischemic brain injury by Mg^(2+)/H_(2) released from endovascular Mg implant
《Bioactive Materials》2024年第12期124-139,共16页Yang Zhang Hongkang Zhang Miaowen Jiang Xiaofeng Cao Xiaoxiao Ge Baoying Song Jing Lan Wenhao Zhou Zhengfei Qi Xuenan Gu Juzhe Liu Yufeng Zheng Ming Li Xunming Ji 
funded by National Natural Science Foundation of China(82027802,82102220);Research Funding on Translational Medicine from Beijing Municipal Science and Technology Commission(Z221100007422023);Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support(YGLX202325);Non-profit Central Research Institute Fund of Chinese Academy of Medical(2023-JKCS-09);Beijing Association for Science and Technology Youth Talent Support Program(BYESS2022081);Science and Technology Innovation Service Capacity Building Project of Beijing Municipal Education Commission(11000023T000002157177);Outstanding Young Talents Program of Capital Medical University(B2305),Beijing Municipal Natural Science Foundation(7244510),Beijing Nova Program(20230484286).
recanalization.Yet,due to ischemia-reperfusion injury,over half of these patients still experience poor prognoses.Thus,neuroprotective treatment is imperative to alleviate the ischemic brain injury,and a proof-of-conc...
关键词：MAGNESIUM Acute ischemic stroke NEUROPROTECTION Biodegradable implantation Hydrogen 
Harnessing the power of artificial intelligence for human living organoid research
《Bioactive Materials》2024年第12期140-164,共25页Hui Wang Xiangyang Li Xiaoyan You Guoping Zhao 
supported by the Tianjin Synthetic Biotechnology Innovation Capacity Improvement Projects(TSBICIP-CXRC-008);Strategic Priority Research Program of the Chinese Academy of Sciences(XDC 0110300);Major Project of Haihe Laboratory of Synthetic Biology(E2M9560201);National Natural Science Foundation of China(32301210&31200035);the China Postdoctoral Science Foundation(No.2022M713330).
As a powerful paradigm,artificial intelligence(AI)is rapidly impacting every aspect of our day-to-day life and scientific research through interdisciplinary transformations.Living human organoids(LOs)have a great pote...
关键词：Artificial intelligence Human living organoids Organoid intelligence In vitro miniature organ models Multidisciplinary techniques Preclinical-to-clinical transformation 
A biomimetic upconversion nanoreactors for near-infrared driven H2 release to inhibit tauopathy in Alzheimer’s disease therapy
《Bioactive Materials》2024年第12期165-177,共13页Qin Zhang Chuanqi Li Bohan Yin Jiaxiang Yan Yutian Gu Yingying Huang Jiareng Chen Xinyue Lao Jianhua Hao Changqing Yi Yi Zhou James Chung Wai Cheung Siu Hong Dexter Wong Mo Yang 
supported by the Shenzhen Science and Technology Program-Basic Research Scheme(JCYJ20220531090808020);the Research Grants Council(RGC)of Hong Kong Collaborative Research Grant(C5005-23W and C5078-21E);the Research Grants Council(RGC)of Hong Kong General Research Grant(PolyU 15217621 and PolyU 15216622);the Guangdong-Hong Kong Technology Cooperation Funding Scheme(GHP/032/20SZ and SGDX20201103095404018);the Hong Kong Polytechnic University Shenzhen Institute Bai Cheng Bai Yuan Fund(I2022A002);PolyU Internal Fund(1-YWB4,1-WZ4E,1-CD8M,1-WZ4E,1-CEB1,1-YWDU,1-CE2J and 1-W02C);the funding from the Laboratory for Marine Drugs and Bioproducts,Qingdao Marine Science and Technology Center(No.:LMDBCXRC202401 and LMDBCXRC202402);Shandong Provincial Overseas Excellent Young Scholar Program(2024HWYQ-042 and 2024HWYQ-043);Taishan Scholar Youth Expert Program of Shandong Province(tsqn202306102 and tsqn202312105)supporting this work;supported by the University Research Facility in Life Sciences of the Hong Kong Polytechnic University.
Abnormal hyperphosphorylation of tau protein is a principal pathological hallmark in the onset of neurodegenerative disorders,such as Alzheimer’s disease(AD),which can be induced by an excess of reactive oxygen speci...
关键词：Artificial photosynthesis Hydrogen therapy Oxidative stress Tau hyperphosphorylation Alzheimer’s disease 
An immunotherapeutic hydrogel booster inhibits tumor recurrence and promotes wound healing for postoperative management of melanoma
《Bioactive Materials》2024年第12期178-193,共16页Yuanyuan Yang Bo Zhang Yangtao Xu Wenxiang Zhu Zinian Zhu Xibo Zhang Wenze Wu Jierong Chen Zhiqiang Yu 
supported by the National Natural Science Foundation of China(82372115 and 52073139);the China Postdoctoral Science Foundation(2023M731571);Dongguan Science and Technology of Social Development Program(20231800900322 and 20231800900362);the Postdoctoral Research Project Start-Up Funding of Dongguan People’s Hospital(319341);the Guangdong Basic and Applied Basic Research Foundation(2023B1515120084 and 2023A1515110016);the Training Program of National Natural Science Foundation of Dongguan People’s Hospital(Z202402).
Low tumor immunogenicity,immunosuppressive tumor microenvironment,and bacterial infections have emerged as significant challenges in postsurgical immunotherapy and skin regeneration for preventing melanoma recurrence....
关键词：Glutamine metabolism IMMUNOTHERAPY HYDROGEL MELANOMA Wound healing 
Dynamic compliance penis enlargement patch
《Bioactive Materials》2024年第12期194-206,共13页Rui Zheng Wenwen Zhong Muyuan Chai Xuetao Shi 
the financial support from the National Key Research and Development Program of China(2021YFB3800800);the National Natural Science Foundation of China(U22A20157,32401141);the Guangdong Basic and Applied Basic Research Foundation(2022B1515130010,2023A1515110794,2024B1515040030);the Postdoctoral Fellowship Program of CPSF under Grant Number GZC20231080;the China Postdoctoral Science Foundation(2024M751311).
Men are particularly sensitive to penis size,especially those with a deformed or injured penis.This can lead to a strong desire for penis enlargement surgery.Given the ethical sensitivities of the penis,penile implant...
关键词：Polyvinyl alcohol HYDROGEL Negative Poisson’s ratio Crystallization enhancement Penis enlargement 
Versatile effects of galectin-1 protein-containing lipid bilayer coating for cardiovascular applications
《Bioactive Materials》2024年第12期207-225,共19页Md Lemon Hasan Ju Ro Lee Khandoker Asiqur Rahaman Dae Hyeok Yang Yoon Ki Joung 
supported by grants the Nano Material Technology Development Program(NRF-2021M3H4A1A04092879)through the National Research Foundation of Korea(NRF)funded by the Ministry of Science and ICT;the Materials and Parts Technology Development Program(20023353);Advanced Technology Center(ATC+,20017939)funded by the Ministry of Trade,Industry&Energy(MOTIE,Korea).
Modulating inflammatory cells in an implantation site leads to severe complications and still unsolved challenges for blood-contacting medical devices.Inspired by the role of galectin-1(Gal-1)in selective functions on...
关键词：Galectin-1 protein Supported lipid bilayer MACROPHAGE Cardiovascular devices Inflammation 
Amphiphilic cytokine traps remodel marrow adipose tissue for hematopoietic microenvironment amelioration
《Bioactive Materials》2024年第12期226-240,共15页Shunshu Deng Shuang Zhang Tong Shen Xuanlin Wang Zehua Gao Wenchao Zhang Kai Dai Jing Wang Changsheng Liu 
supported by the Basic Science Center Program of National Natural Science Foundation of China(No.T2288102);the Key Program of the National Natural Science Foundation of China(No.32230059);the National Natural Science Foundation of China(No.32301123);the Foundation of Frontiers Science Center for Materiobiology and Dynamic Chemistry(No.JKVD1211002);the Wego Project of Chinese Academy of Sciences[No.(2020)005];the China Postdoctoral Science Foundation(No.2022M721147);the Project of National Facility for Translational Medicine(Shanghai)(No.TMSK-2021-134);the Peak Disciplines(Type IV)of Institutions of Higher Learning in Shanghai.
Hematopoietic stem cell transplantation(HSCT)is extensively employed in the treatment of hematological malignancies but is markedly constrained by the paucity of hematopoietic stem/progenitor cells(HSPCs).Recent studi...
关键词：ADIPOCYTES HEMATOPOIESIS In vivo osteo-organoids Stem cell factor Sulfated chitosan Tissue regeneration 
ECM-mimicking composite hydrogel for accelerated vascularized bone regeneration
《Bioactive Materials》2024年第12期241-256,共16页Guanglong Li Fei Gao Donglei Yang Lu Lin Weijun Yu Jiaqi Tang Ruhan Yang Min Jin Yuting Gu Pengfei Wang Eryi Lu 
supported by National Natural Science Foundation of China(Grant Nos.52171075,52103172,82271589);Science and Technology Commission of Shanghai Municipality(Grant Nos.21DZ2294700,21ZR1439400);Opening Project of Shanghai Key Laboratory of Orthopaedic Implant(Grant No.KFKT2021001);the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(Grant No.2023-JKCS-14);Incubating Program for National Program of Renji Hospital,Shanghai Jiao Tong University School of Medicine(Grant No.RJTJ23-PY-053);“Clinic Plus”Outstanding Project of Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine(Grant No.2021ZYA009).
Bioactive hydrogel materials have great potential for applications in bone tissue engineering.However,fabrication of functional hydrogels that mimic the natural bone extracellular matrix(ECM)remains a challenge,becaus...
关键词：Composite hydrogel DNA hydrogel Stress relaxation OSTEOGENESIS VASCULARIZATION 
3-D bioprinted human-derived skin organoids accelerate full-thickness skin defects repair被引量：1
《Bioactive Materials》2024年第12期257-269,共13页Tao Zhang Shihao Sheng Weihuang Cai Huijian Yang Jiameng Li Luyu Niu Wanzhuo Chen Xiuyuan Zhang Qirong Zhou Chuang Gao Zuhao Li Yuanwei Zhang Guangchao Wang Hao Shen Hao Zhang Yan Hu Zhifeng Yin Xiao Chen Yuanyuan Liu Jin Cui Jiacan Su 
Science Foundation of China(NO.92249303,NO.82230071,No.82172098,No.82371603);Jiangsu Province Natural Science and Technological Project(No.BK20231218);Experimental Animal Research Field Project Shanghai Science and Technology Commission(No.23141900600);Research Physician Innovation and Transformation Ability Training Project from Shanghai Health Commission(No.SHDC2023CRT013);Basic Medical Innovation Project of Changhai Hospital(No.20237Y38);Deep Blue Talent Project of Naval Medical University(Jin Cui);Shanghai Oriental Talent Program(Xiao Chen,Yuanyuan Liu).
The healing of large skin defects remains a significant challenge in clinical settings.The lack of epidermal sources,such as autologous skin grafting,limits full-thickness skin defect repair and leads to excessive sca...
关键词：Skin organoid Skin defect 3D bioprinting Wound healing 
Monascus pigment-protected bone marrow-derived stem cells for heart failure treatment
《Bioactive Materials》2024年第12期270-283,共14页Tian Yue Wentai Zhang Haifeng Pei Dunzhu Danzeng Jian He Jiali Yang Yong Luo Zhen Zhang Shiqiang Xiong Xiangbo Yang Qisen Ji Zhilu Yang Jun Hou 
supported by the National Natural Science Foundation of China(81900339,82072072,32261160372);The Third People’s Hospital of Chengdu First-Class Incubation Project(CSY-YN-01-2023-003);Special Funding for Postdoctoral Research in Sichuan Province(2023TB095);The Fundamental Research Funds for the Central Universities(2682022TPY052);Chengdu Medical Research Project(2022138);the Natural Science Foundation of Tibet Autonomous Region Grant number(XZ202201ZR0036G).
Mesenchymal stem cells(MSCs)have demonstrated significant therapeutic potential in heart failure(HF)treatment.However,their clinical application is impeded by low retention rate and low cellular activity of MSCs cause...
关键词：BMSCS Monascus pigment Heart failure HYDROGEL MICROENVIRONMENT 
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