ORIGEN

作品数：68被引量：294H指数：10
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相关作者：张春明余纲林王侃田文喜秋穗正更多>>
相关机构：清华大学中华人民共和国环境保护部华北电力大学西安交通大学更多>>
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Wnt/GSK-3βmediates posttranslational modifications of FLYWCH1 to regulate intestinal epithelial function and tumorigenesis in the colon
《Cancer Communications》2025年第1期9-14,共6页Sheema Almozyan Roya Babaei-Jadidi Abrar Aljohani Sepideh Youssefi William Dalleywater Prerna Kadam Bradley Spencer-Dene Emad Rakha Mohammad Ilyas Abdolrahman Shams Nateri 
supported by the Medical Research Council(MRC)(grant number G0700763);by the University of Nottingham,Nottingham,UK.
The intestinal epithelium undergoes rapid renewal,with the entire epithelial layer replaced within five days.Intestinal stem cells(ISCs),located in the intestinal crypts,generate all differentiated cell types necessar...
关键词：TUMORIGENESIS COLON HOMEOSTASIS 
Phase separation of SPIN1 through its IDR facilitates histone methylation readout and tumorigenesis
《Journal of Molecular Cell Biology》2024年第6期28-42,共15页Yukun Wang Yuhan Chen Mengyao Li Jiayue Wang Yuhan Jiang Rong Xie Yifeng Zhang Zhihua Li Zhenzhen Yan Chen Wu 
National Natural Science Foundation of China(32071277);Science and Technology Program of Hebei Province(216Z2602G);Natural Science Foundation of Hebei Province(C2021201012);Interdisciplinary Research Program of Natural Science of Hebei University(DXK202006).
Spindlin1(SPIN1)is a unique multivalent histone modification reader that plays a role in ribosomal RNA transcription,chromosome segregation,and tumorigenesis.However,the function of the extended N-terminal region of S...
关键词：SPIN1 IDR phase separation histone methylation reader TUMORIGENESIS 
Regulatory effects of miR-19a on MAD2 expression and tumorigenesis in gastric cancer
《Genes & Diseases》2023年第4期1180-1182,共3页J.Bargiela-Iparraguirre J.M.Herrero N.Pajuelo-Lozano M.Perez R.Perona A.G.Quiroga C.Calés I.Sanchez-Perez 
MICINN grant number PID2019-106220RB100.Instituto de Salud CarlosⅢ,Spain,grant PI200335,(all co-financed through Fondo Europeo de Desarrollo Regional(FEDER)"Una manera de hacer Europa");supported by a grant FPU15/04669,funded by Ministerio de Educacion,Cultura y Deporte,Spain.JMH FPI-UAM 2021 from Universidad Auton-oma de Madrid(Molecular BioSciences PhD programme).
Gastric cancer(GC)is worldwide the sixth most diagnosed and third leading cause of cancer deaths,with poor and late prognosis,probably due to post-surgery adjuvant treatment resistance and lack of a thorough panel of ...
关键词：MAD2 TUMORIGENESIS GASTRIC 
lncRNA cytoskeleton regulator RNA(CYTOR):Diverse functions in metabolism,inflammation and tumorigenesis,and potential applications in precision oncology
《Genes & Diseases》2023年第2期415-429,共15页Chunlin Ou Xiaoyun He Yong Liu Xin Zhang 
supported by the National Natural Science Foundation of China(No.81974424,81874133,81772903 and 81903032);Natural Science Foundation of Hunan Province,China(No.2018JJ2630 and 2021JJ41013);the Huxiang Young Talent Project,China(No.2018RS3024);the China Postdoctoral Science Foundation(No.2020M672520);the Youth Fund of Xiangya Hospital,China(No.2018Q011).
Long non-coding RNAs(lncRNAs)are a novel class of non-coding RNA(ncRNA),that have been studied extensively in the field of tumor research in recent years.In the case of tumor-associated lncRNAs,lncRNA cytoskeleton reg...
关键词：CYTOR GSEA INFLAMMATION LncRNAs Therapy TUMORIGENESIS 
AMP-activated protein kinaseβ1 orβ2 deletion enhances colon cancer cell growth and tumorigenesis
《Acta Biochimica et Biophysica Sinica》2022年第8期1140-1147,共8页Fuli Shi Zhimin Tang Shanshan Jiang Zhijuan Xiong Wansi Zhang Yuanjun Li Hui Lin Zhijun Luo Ying Ying 
This work was supported by the grants from the National Natural Science Foundation of China(No.81572753);the Science and Technology Foundation of Jiangxi Province(No.20212BAB206039);an Innovation and Entrepreneurship Grant from Jiangxi Province Bureau of Foreign Experts.
Abnormal metabolism is a major hallmark of cancer and has been validated as a therapeutic target.Adenine monophosphate-activated protein kinase(AMPK),anαβγheterotrimer,performs essential functions in cancer progres...
关键词：AMPKβ1 AMPKβ2 Warburg effect TUMORIGENESIS colon cancer 
SATB2:A versatile transcriptional regulator of craniofacial and skeleton development,neurogenesis and tumorigenesis,and its applications in regenerative medicine被引量：1
《Genes & Diseases》2022年第1期95-107,I0005,共14页Xia Huang Qiuman Chen Wenping Luo Mikhail Pakvasa Yuxin Zhang Liwen Zheng Shuang Li Zhuohui Yang Huan Zeng Fang Liang Fugui Zhang Daniel A.Hu Kevin H.Qin Eric J.Wang David S.Qin Russell R.Reid Tong-Chuan He Aravind Athiviraham Mostafa El Dafrawy Hongmei Zhang 
This reported work was supported in part by research grants from the National Natural Science Foundation of China(No.#81870758 to HZ);Chongqing Research Program of Basic Research and Frontier Technology(No.#cstc2017jcyjAX0020 to HZ).
SATB2(special AT-rich sequence-binding protein 2)is a member of the special AT-rich binding protein family.As a transcription regulator,SATB2 mainly integrates higher-order chromatin organization.SATB2 expression appe...
关键词：Bone regeneration DEVELOPMENT NEUROGENESIS SATB2 TUMORIGENESIS 
Insights into the Pathogenesis of Preeclampsia Based on the Features of Placentation and Tumorigenesis
《Reproductive and Developmental Medicine》2021年第2期97-106,共10页Yun-Qing Zhu Xing-Yu Yan Hua Li Cong Zhang 
This study was supported by grants from the National Key R&D Program of China(2019YFA0802600 and 2017YFC1001403);NSFC(31871512 and 31671199)to CZ;Support was also obtained by the Shanghai Commission of Science and Technology(17DZ2271100).
Placentation and tumorigenesis have many common features.Human placentation builds a maternal-fetal connection,circumvents maternal immune rejection of the fetus,and utilizes mechanisms that support tumorigenesis,such...
关键词：PATHOGENESIS PLACENTATION PREECLAMPSIA TUMORIGENESIS 
Lung stem cells in regeneration and tumorigenesis
《Journal of Genetics and Genomics》2021年第4期268-276,共9页Yuting Chen Yun Xue Yujuan Jin Hongbin Ji 
supported by the National Natural Science Foundation of China(81402371 to Y.J.,82030083 to H.J.,91731314 H.J.,81872312 to H.J.,82011540007 to H.J.,31621003 to H.J.);the National Basic Research Program of China(2017YFA0505501 to H.J.;2020YFA0803300 to H.J.);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB19020201 to H.J.);the Basic Frontier Scientific Research Program of Chinese Academy of Science(ZDBS-LY-SM006 to H.J.);the International Cooperation Project of Chinese Academy of Sciences(153D31KYSB20190035 to H.J.)。
Adult lung is a highly quiescent organ,with extremely low cell turnover frequency.However,emerging evidences support the occurrence of repair and regeneration in pulmonary epithelia in response to various injuries.Lun...
关键词：Lung stem cells Lung cancer REGENERATION TUMORIGENESIS Pathological transition 
Insulin gene enhancer protein 1 mediates glycolysis and tumorigenesis of gastric cancer through regulating glucose transporter 4被引量：8
《Cancer Communications》2021年第3期258-272,共15页Ting Guo Yan-Hua Bai Xiao-Jing Cheng Hai-Bo Han Hong Du Ying Hu Shu-Qin Jia Xiao-Fang Xing Jia-Fu Ji 
Natural Science Foundation of Beijing,Grant/Award Number:7132051;National Natural Science Foundation of China,Grant/Award Numbers:81301874,81972758,81872502,81802471;Interdisciplinary Medicine Seed Fund of Peking University,Grant/Award Number:BMU2018MX018;Beijing Municipal Administration of Hospitals’Youth Program,Grant/Award Number:QML20181102;National High Technology Research and Development Program of China,Grant/Award Number:2014AA020603;Science Foundation of Peking University Cancer Hospital,Grant/Award Numbers:2017-23,2020-6。
Background:Insulin gene enhancer protein 1,(ISL1),a LIM-homeodomain transcription factor,is involved in multiple tumors and is associated with insulin secretion and metabolic phenotypes.However,the role of ISL1 in sti...
关键词：gastric cancer glucose transporter 4 GLYCOLYSIS insulin gene enhancer protein 1 TUMORIGENESIS 
The potent roles of salt-inducible kinases(SIKs)in metabolic homeostasis and tumorigenesis被引量：7
《Signal Transduction and Targeted Therapy》2020年第1期1141-1155,共15页Zicheng Sun Qiwei Jiang Jie Li Jianping Guo 
supported by National Nature Science Foundation of China(NSFC)to J.G.(31871410);the Guangdong Science and Technology Department Fund to J.L.(2016A040403049 and 2017A010105029).
Salt-inducible kinases(SIKs)belong to AMP-activated protein kinase(AMPK)family,and functions mainly involve in regulating energy response-related physiological processes,such as gluconeogenesis and lipid metabolism.Ho...
关键词：TUMORIGENESIS HOMEOSTASIS KINASES 
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