PHENYLBUTYRATE

作品数：16被引量：38H指数：4
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相关领域：医药卫生生物学更多>>
相关机构：UCL商业有限公司中国医药大学更多>>
相关期刊：《Bioresources and Bioprocessing》《Chinese Journal of Chemical Engineering》《Journal of Cancer Therapy》《Acta Pharmacologica Sinica》更多>>
相关基金：国家自然科学基金更多>>
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Highly efficient synthesis of the chiral ACE inhibitor intermediate(R)-2-hydroxy-4-phenylbutyrate ethyl ester via engineered bi-enzyme coupled systems
《Bioresources and Bioprocessing》2024年第1期1291-1310,共20页Yanmei Dai Jinmei Wang Zijuan Tao Liangli Luo Changshun Huang Bo Liu Hanbing Shi Lan Tang Zhimin Ou 
supported by the Zhejiang Provincial Science and Technology Plan Project(2024C03014);the National Nature Science Foundation of China(Project Nos.21978267,and 22078300);as well as the Natural Science Foundation of Heilongjiang Province(LH2022H107).
(R)-2-Hydroxy-4-phenylbutyric acid ethyl ester((R)-HPBE)is an essential chiral intermediate in the synthesis of angiotensin-converting enzyme(ACE)inhibitors.Its production involves the highly selective asymmetric redu...
关键词：Carbonyl reductase Bi-enzyme coupled Fusion-expression High-density fermentation Substrate feeding strategy 
Sodium 4-phenylbutyrate Attenuates High-fat Diet-induced Impaired Spermatogenesis
《Biomedical and Environmental Sciences》2018年第12期876-882,共7页WANG Er Hui YAO San Qiao TAO Ling XI Jin Yan 
supported by the National Natural Science Foundation of China [Grant No.81703230];the Key Scientific Research Project of Universities in Henan Province [Grant No.16B330001 and No.17A330005]
Objective To determine the mitigating effects of sodium 4-phenylbutyrate(4-PBA) on high-fat diet(HFD)-induced spermatogenesis dysfunction. Methods Male rats(n = 30) were randomly divided into three groups: control, HF...
关键词：Male infertility Sodium 4-phenylbutyrate Obesity SPERMATOGENESIS SEMEN TESTIS 
The novel resveratrol derivative 3,5-diethoxy-3＇,4＇- dihydroxy-trans-stilbene induces mitochondrial ROS-mediated ER stress and cell death in human hepatoma cells in vitro被引量：6
《Acta Pharmacologica Sinica》2017年第11期1486-1500,共15页Jae-woo PARK Woo-gyun CHOI Phil-jun LEE Su-wol CHUNG Byung-sam KIM Hun-taeg CHUNG Sungchan CliO Jong-heon KIM Byoung-heon KANG Hyoungsu KIM Hong-pyo KIM Sung-hoon BACK 
Resveratrol （3,5,4＇-trihydroxy-trans-stilbene） is a well-known polyphenol that is present in grapes, peanuts, pine seeds, and several other plants. Resveratrol exerts deleterious effects on various types of human c...
关键词：RESVERATROL resveratrol-006 HepG2 human hepatoma cells mitochondria ROS endoplasmic reticulum stress 4-phenylbutyrate NAC Mito-TEMPO apoptosis 
Suppression of fibrosis in human pterygium fibroblasts by butyrate and phenylbutyrate被引量：3
《International Journal of Ophthalmology(English edition)》2017年第9期1337-1343,共7页Yuka Koga Noriaki Maeshige Hiroto Tabuchi Mikiko Uemura Michiko Aoyama-Ishikawa Makoto Miyoshi Chikako Katakami Makoto Usami 
Supported by JSPS KAKENHI(No.23592648)
AIM：To evaluate the antifibrogenic effects of butyrate or phenylbutyrate,a chemical derivative of butyrate,in human pterygium fibroblasts.METHODS：Human pterygium fibroblasts obtained from patient pterygium tissue we...
关键词：BUTYRATE phenylbutymte PTERYGIUM FIBROBLASTS antifibrogenic effect 
Autophagy activation prevents sevoflurane-induced neurotoxicity in H4 human neuroglioma cells被引量：8
《Acta Pharmacologica Sinica》2016年第5期580-588,共9页You-fa ZHOU Qing-xia WANG Hai-yan ZHOU Gang CHEN 
This study was supported by grants from the National Natu- ral Science Foundation of China （No 81371214） and Zhejiang Provincial Natural Science Foundation of China （No LY12H09005）.
Aim： The inhaled anesthetic sevoflurane may induce cognitive impairment in both animals and humans. Previous study has shown that sevoflurane triggers ER stress and may lead to apoptosis in rat hippocampal neurons. I...
关键词：SEVOFLURANE inhalation anesthetics H4 human neuroglioma cells AUTOPHAGY apoptosis ER stress rapamycin 3-MA 4-phenylbutyrate neuroprotection 
A Case of Sustained Objective Response of Recurrent/Progressive Diffuse Intrinsic Pontine Glioma with Phenylbutyrate and Targeted Agents被引量：1
《Journal of Cancer Therapy》2015年第1期40-44,共5页Stanislaw R. Burzynski Gregory S. Burzynski Sheldon Brookman 
Diffuse intrinsic pontine glioma (DIPG) is the most common type of brainstem glioma and one of the most deadly brain tumors. DIPG in young adult patients is a rare disease for which treatment options are limited. Radi...
关键词：Antineoplastons BRAINSTEM GLIOMA DIPG PHENYLBUTYRATE Targeted Agents Treatment of DIPG 
Preliminary Findings on the Use of Targeted Therapy in Combination with Sodium Phenylbutyrate in Colorectal Cancer after Failure of Second-Line Therapy—A Potential Strategy for Improved Survival被引量：7
《Journal of Cancer Therapy》2014年第13期1270-1288,共19页Stanislaw R. Burzynski Tomasz J. Janicki Gregory S. Burzynski Sheldon Brookman 
Colorectal cancer (CRC) is the second leading cause of cancer death related mortality with 1.2 million new cases diagnosed annually worldwide. Despite remarkable advances in the treatment of resectable CRC, advanced d...
关键词：COLORECTAL CANCER COLORECTAL CANCER SURVIVAL PERSONALIZED Targeted Agents Sodium PHENYLBUTYRATE 
Preliminary Findings on the Use of Targeted Therapy with Pazopanib and Other Agents in Combination with Sodium Phenylbutyrate in the Treatment of Glioblastoma Multiforme被引量：1
《Journal of Cancer Therapy》2014年第14期1423-1437,共15页Stanislaw R. Burzynski Tomasz J. Janicki Gregory S. Burzynski Sheldon Brookman 
The most common and aggressive type of brain tumor is glioblastoma multiforme (GBM). The prognosis for GBM remains poor with a five-year survival rate between 1% and 2%. The prospects for patients with recurrent GBM (...
关键词：Gliobastoma MULTIFORME Personalized Targeted AGENTS Sodium PHENYLBUTYRATE TREATMENT of GLIOBLASTOMA MULTIFORME 
Preliminary Findings on the Use of Targeted Therapy in Combination with Sodium Phenylbutyrate in Recurrent Advanced Pancreatic Cancer—A Potential Strategy for Improved Survival被引量：2
《Journal of Cancer Therapy》2014年第12期1072-1091,共20页Stanislaw R. Burzynski Tomasz J. Janicki Gregory S. Burzynski Sheldon Brookman 
Metastatic pancreatic cancer carries an estimated five-year survival rate of only 2%. Gemcitabine-based chemotherapy remains a first-line standard-of-care treatment for elderly patients with advanced pancreatic cancer...
关键词：PANCREATIC CANCER PANCREATIC CANCER SURVIVAL PERSONALIZED Targeted Therapy Sodium PHENYLBUTYRATE 
Preliminary Findings on the Use of Targeted Therapy in Combination with Sodium Phenylbutyrate in Advanced Malignant Mesothelioma: A Strategy for Improved Survival
《Journal of Cancer Therapy》2014年第12期1127-1144,共18页Stanislaw R. Burzynski Tomasz J. Janicki Gregory S. Burzynski Sheldon Brookman 
Advanced malignant mesothelioma (MM) is among the most aggressive and difficult-to-treat diseases. Industrialization and exposure to asbestos is the main causative factor for the dramatic increase in the incidence of ...
关键词：MESOTHELIOMA MESOTHELIOMA SURVIVAL PERSONALIZED TARGETED Therapy Antineoplastons Sodium PHENYLBUTYRATE Clinical Studies 
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