supported by the STI2030-Major Projects(2021ZD0204001);the National Natural Science Foundation of China(92049120,81870897,81271424,81671111,and 62475179);the Sino German Cooperation and Exchange Project(M-0679);the Guangdong Key Project in the Development of New Tools for the Diagnosis and Treatment of Autism(2018B030335001);the Natural Science Foundation of Jiangsu Province(BK20181436);the Priority Academic Program Development of Jiangsu Higher Education Institutions,the Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases(BM2013003);Suzhou International Joint Laboratory for Diagnosis and Treatment of Brain Diseases,Suzhou Science and Technology Plan Medical and Health Care Science and Technology Innovation Applied Basic Research(SKY2022161);the Research Project of Neurological Diseases in the Second Affiliated Hospital of Soochow University Research Center(ND2023A01);Boxi clinical research project of The First Affiliated Hospital of Soochow University(BXQN202204);Suzhou Science&Technology Projects for People's Livelihood(SKY2021065);Wuxi Municipal Health Commission(M202204).
Oligodendrocyte lineage cells, including oligodendrocyte precursor cells (OPCs) and oligodendrocytes (OLs), are essential in establishing and maintaining brain circuits. Autophagy is a conserved process that keeps the...
supported by grants from the National Natural Science Foundation of China (32271034,32070964,81971309,32170980,and 32300791);National Key Research and Development Program of China (2021ZD0201703);Chongqing Natural Science Fund for Distinguished Young Scholars (CSTB2023NSCQ-JQX0030);Guangdong Basic and Applied Basic Research Foundation (2022B1515020012,2021A1515110268,2023A1515010651);Shenzhen Medical Research Fund (A2303014);Shenzhen Fundamental Research Program (JCYJ20210324123212035,RCYX20200714114644167,ZDSYS20220606100801003,RCBS20210706092411028,and JCYJ20210324121214039);Shenzhen Key Laboratory of Chinese Medicine Active Substance Screening and Translational Research (ZDSYS20220606100801003).
Oligodendrocyte precursor cells(OPCs)are a heterogeneous multipotent population in the central nervous system(CNS)that appear during embryogenesis and persist as resident cells in the adult brain parenchyma.OPCs could...
supported by grants from the National Nature Science Foundation of China(32271034,32070964,82301703,32300791,and 81901378);Science and Technology Innovation Enhancement Project of Army Medical University(2022XQN40);National Key Research and Development Program of China(2021ZD0201703);Chongqing Natural Science Fund for Distinguished Young Scholars(CSTB2023NSCQ-JQX0030);Undergraduate Research Cultivation Project of Army Medical University(2020XBK16);Guangdong Basic and Applied Basic Research Foundation(2021A1515110268 and 2023A1515010651);Shenzhen Fundamental Research Program(RCBS20210706092411028 and JCYJ20210324121214039).
Posttraumatic stress disorder(PTSD)is a complex mental disorder notable for traumatic experience memory.Although current first-line treatments are linked with clinically important symptom reduction,a large proportion ...
supported by the National Natural Science Foundation of China(81801147 and 81971112).
Chronic cerebral hypoperfusion is one of the pathophysiological mechanisms contributing to cognitive decline by causing white matter injury.Microglia phagocytosing myelin debris in a timely manner can promote remyelin...
supported by the National Natural Science Foundation of China(92268118,82071396,82271199,and 31970771);the Shaanxi Provincial Key R&D Foundation(2021ZDLSF03-09);the Fundamental Research Funds for the Central Universities(GK202201013,GK202202006,and GK202105002);the Tian Jia Bing Scholar Program.
Multiple sclerosis(MS)is a chronic and incurable autoimmune disease of the central nervous system(CNS)that results in neuro-inflammation and demyelination.Current therapies for MS alleviate symptoms to some extent but...
supported by the Ministry of Science and Technology of China(2021ZD0201700);the National Natural Science Foundation of China(31921003).
Astrocytes(ASTs)and oligodendroglial lineage cells(OLGs)are major macroglial cells in the central nervous system.ASTs communicate with each other through connexin(Cx)and Cx-based network structures,both of which allow...
supported by a grant from the National Institute of Aging,National Institutes of Health(1RF1AG058603).
The myelin sheath-supporting cells,oligodendrocytes and Schwann cells,are susceptible toischemia.Therefore,ischemic stroke is usually characterized by evident demyelination^([l]).Although oligodendrocytes are the majo...
This insight article was supported by the Natural Science Foundation of Zhejiang Province(LQ19C090001);the National Natural Science Foundation of China(31900703 and 31771621).
The myelin regulatory factor gene(MYRF)encodes a protein evolutionarily conserved from invertebrates to vertebrates,representing a novel type of membrane-bound transcriptional factor(MBTF).In vertebrates,MYRF protein ...
supported by the Natural Science Foundation of Zhejiang Province,China(LY17C090006,LQ16C090004,and LY18H090014)。
Dear Editor,Myelin,the lipid-rich insulation that supports the integrity of axons,enables rapid conduction of nerve impulses and information flow to distant brain areas[1].Oligodendrocytes(OLs)are glial cells that mye...