MYELIN

作品数:165被引量:310H指数:9
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相关领域:医药卫生生物学更多>>
相关作者:丛林海王美兰汤勇吴锡芳杨一兵更多>>
相关机构:昆明医科大学北京协和医院重庆医科大学广州军区武汉总医院更多>>
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Correction to:Autophagy in Oligodendrocyte Lineage Cells Controls Oligodendrocyte Numbers and Myelin Integrity in an Age‑dependent Manner
《Neuroscience Bulletin》2025年第3期547-548,共2页
Autophagy in Oligodendrocyte Lineage Cells Controls Oligodendrocyte Numbers and Myelin Integrity in an Age‑dependent Manner
《Neuroscience Bulletin》2025年第3期374-390,共17页Hong Chen Gang Yang De‑En Xu Yu‑tong Du Chao Zhu Hua Hu Li Luo Lei Feng Wenhui Huang Yan‑Yun Sun Quan‑Hong Ma 
supported by the STI2030-Major Projects(2021ZD0204001);the National Natural Science Foundation of China(92049120,81870897,81271424,81671111,and 62475179);the Sino German Cooperation and Exchange Project(M-0679);the Guangdong Key Project in the Development of New Tools for the Diagnosis and Treatment of Autism(2018B030335001);the Natural Science Foundation of Jiangsu Province(BK20181436);the Priority Academic Program Development of Jiangsu Higher Education Institutions,the Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases(BM2013003);Suzhou International Joint Laboratory for Diagnosis and Treatment of Brain Diseases,Suzhou Science and Technology Plan Medical and Health Care Science and Technology Innovation Applied Basic Research(SKY2022161);the Research Project of Neurological Diseases in the Second Affiliated Hospital of Soochow University Research Center(ND2023A01);Boxi clinical research project of The First Affiliated Hospital of Soochow University(BXQN202204);Suzhou Science&Technology Projects for People's Livelihood(SKY2021065);Wuxi Municipal Health Commission(M202204).
Oligodendrocyte lineage cells, including oligodendrocyte precursor cells (OPCs) and oligodendrocytes (OLs), are essential in establishing and maintaining brain circuits. Autophagy is a conserved process that keeps the...
关键词:AUTOPHAGY Oligodendrocyte precursor cells OLIGODENDROCYTES MYELINATION Myelin proteins Turnover Degradation 
A New Acquaintance of Oligodendrocyte Precursor Cells in the Central Nervous System
《Neuroscience Bulletin》2024年第10期1573-1589,共17页Zexuan Ma Wei Zhang Chenmeng Wang Yixun Su Chenju Yi Jianqin Niu 
supported by grants from the National Natural Science Foundation of China (32271034,32070964,81971309,32170980,and 32300791);National Key Research and Development Program of China (2021ZD0201703);Chongqing Natural Science Fund for Distinguished Young Scholars (CSTB2023NSCQ-JQX0030);Guangdong Basic and Applied Basic Research Foundation (2022B1515020012,2021A1515110268,2023A1515010651);Shenzhen Medical Research Fund (A2303014);Shenzhen Fundamental Research Program (JCYJ20210324123212035,RCYX20200714114644167,ZDSYS20220606100801003,RCBS20210706092411028,and JCYJ20210324121214039);Shenzhen Key Laboratory of Chinese Medicine Active Substance Screening and Translational Research (ZDSYS20220606100801003).
Oligodendrocyte precursor cells(OPCs)are a heterogeneous multipotent population in the central nervous system(CNS)that appear during embryogenesis and persist as resident cells in the adult brain parenchyma.OPCs could...
关键词:Oligodendrocyte precursor cell OPC-neuron synapse-Myelin-independent roles Heterogeneity:Migration Proliferation Differentiation 
Fluoxetine Rescues Excessive Myelin Formation and Psychological Behaviors in a Murine PTSD Model
《Neuroscience Bulletin》2024年第8期1037-1052,共16页Chenrui Yin Kefei Luo Xinyue Zhu Ronghang Zheng Yu Wang Guangdan Yu Xiaorui Wang Fei She Xiaoying Chen Tao Li Jingfei Chen Baduojie Bian Yixun Su Jianqin Niu Yuxin Wang 
supported by grants from the National Nature Science Foundation of China(32271034,32070964,82301703,32300791,and 81901378);Science and Technology Innovation Enhancement Project of Army Medical University(2022XQN40);National Key Research and Development Program of China(2021ZD0201703);Chongqing Natural Science Fund for Distinguished Young Scholars(CSTB2023NSCQ-JQX0030);Undergraduate Research Cultivation Project of Army Medical University(2020XBK16);Guangdong Basic and Applied Basic Research Foundation(2021A1515110268 and 2023A1515010651);Shenzhen Fundamental Research Program(RCBS20210706092411028 and JCYJ20210324121214039).
Posttraumatic stress disorder(PTSD)is a complex mental disorder notable for traumatic experience memory.Although current first-line treatments are linked with clinically important symptom reduction,a large proportion ...
关键词:PTSD Fear memory MYELINATION Oligodendroglial differentiation FLUOXETINE Wnt signaling 
MFG-E8 Alleviates Cognitive Impairments Induced by Chronic Cerebral Hypoperfusion by Phagocytosing Myelin Debris and Promoting Remyelination被引量:2
《Neuroscience Bulletin》2024年第4期483-499,共17页Xiaohong Dong Zhi Zhang Xin Shu Zi Zhuang Pinyi Liu Renyuan Liu Shengnan Xia Xinyu Bao Yun Xu Yan Chen 
supported by the National Natural Science Foundation of China(81801147 and 81971112).
Chronic cerebral hypoperfusion is one of the pathophysiological mechanisms contributing to cognitive decline by causing white matter injury.Microglia phagocytosing myelin debris in a timely manner can promote remyelin...
关键词:White matter injury Cognitive dysfunction MFG-E8 REMYELINATION Microglial phagocytosis 
Peroxisome Proliferator-Activated Receptor-γCoactivator-1αin the Spotlight with Multiple Sclerosis
《Neuroscience Bulletin》2024年第2期268-272,共5页Ya-Na Yang Mao-Qing Zhang Feng-Lin Yu Bing Han Ming-Yue Bao Yan He Xing Li Yuan Zhang 
supported by the National Natural Science Foundation of China(92268118,82071396,82271199,and 31970771);the Shaanxi Provincial Key R&D Foundation(2021ZDLSF03-09);the Fundamental Research Funds for the Central Universities(GK202201013,GK202202006,and GK202105002);the Tian Jia Bing Scholar Program.
Multiple sclerosis(MS)is a chronic and incurable autoimmune disease of the central nervous system(CNS)that results in neuro-inflammation and demyelination.Current therapies for MS alleviate symptoms to some extent but...
关键词:INFLAMMATION MYELIN AUTOIMMUNE 
Interactions Between Astrocytes and Oligodendroglia in Myelin Development and Related Brain Diseases被引量:1
《Neuroscience Bulletin》2023年第3期541-552,共12页Xuelian Hu Guangdan Yu Xiang Liao Lan Xiao 
supported by the Ministry of Science and Technology of China(2021ZD0201700);the National Natural Science Foundation of China(31921003).
Astrocytes(ASTs)and oligodendroglial lineage cells(OLGs)are major macroglial cells in the central nervous system.ASTs communicate with each other through connexin(Cx)and Cx-based network structures,both of which allow...
关键词:ASTROCYTE OLIGODENDROGLIA Glial network MYELINATION SYNAPTOGENESIS Neuroinfammation 
Astrocyte-Mediated Myelin Phagocytosis in Ischemia
《Neuroscience Bulletin》2023年第1期167-169,共3页Luodan Yang Dongyu Zhang Quanguang Zhang 
supported by a grant from the National Institute of Aging,National Institutes of Health(1RF1AG058603).
The myelin sheath-supporting cells,oligodendrocytes and Schwann cells,are susceptible toischemia.Therefore,ischemic stroke is usually characterized by evident demyelination^([l]).Although oligodendrocytes are the majo...
关键词:MYELIN cytes DEBRIS 
MYRF:A Mysterious Membrane-bound Transcription Factor Involved in Myelin Development and Human Diseases被引量:2
《Neuroscience Bulletin》2021年第6期881-884,共4页Hao Huang Fang Zhou Shiyou Zhou Mengsheng Qiu 
This insight article was supported by the Natural Science Foundation of Zhejiang Province(LQ19C090001);the National Natural Science Foundation of China(31900703 and 31771621).
The myelin regulatory factor gene(MYRF)encodes a protein evolutionarily conserved from invertebrates to vertebrates,representing a novel type of membrane-bound transcriptional factor(MBTF).In vertebrates,MYRF protein ...
关键词:MYELIN representing DISEASES 
TAPP1 Represses the Differentiation of Oligodendrocyte and its Deficiency Accelerates Myelin Regeneration after Demyelinating Injuries被引量:2
《Neuroscience Bulletin》2021年第3期385-388,共4页Ruyi Mei Jiaying Fu Chunxia Jiang Junlin Yang Kang Zheng Aifen Yang Mengsheng Qiu Xiaofeng Zhao 
supported by the Natural Science Foundation of Zhejiang Province,China(LY17C090006,LQ16C090004,and LY18H090014)。
Dear Editor,Myelin,the lipid-rich insulation that supports the integrity of axons,enables rapid conduction of nerve impulses and information flow to distant brain areas[1].Oligodendrocytes(OLs)are glial cells that mye...
关键词:insulation conduction enable 
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