HYPOXIA-ISCHEMIA

作品数：41被引量：201H指数：9
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相关领域：医药卫生更多>>
相关作者：张玲妹张研孙凤艳马正良于常州更多>>
相关机构：江苏省麻醉医学研究所上海医科大学南京大学医学院附属鼓楼医院巴斯克大学更多>>
相关期刊：《Chinese Journal of Traumatology》《Cellular & Molecular Immunology》《Acta Pharmacologica Sinica》《International Journal of Ophthalmology(English edition)》更多>>
相关基金：国家自然科学基金广东省自然科学基金江苏省卫生厅科研基金更多>>
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  • 期刊=Neural Regeneration Researchx
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Reperfusion after hypoxia-ischemia exacerbates brain injury with compensatory activation of the antiferroptosis system:based on a novel rat model被引量：3
《Neural Regeneration Research》2023年第10期2229-2236,共8页Tian-Lei Zhang Zhi-Wei Zhang Wei Lin Xin-Ru Lin Ke-Xin Lin Ming-Chu Fang Jiang-Hu Zhu Xiao-Ling Guo Zhen-Lang Lin 
supported by the National Natural Science Foundation of China,No.82271747(to ZLL);Medical and Health Science and Technology Program of Zhejiang Province of China,No.2023RC048(to WL)。
Hypoxic-ischemic encephalopathy,which predisposes to neonatal death and neurological sequelae,has a high morbidity,but there is still a lack of effective prevention and treatment in clinical practice.To better underst...
关键词：ferroptosis hypoxic-ischemic brain injury hypoxic-ischemic encephalopathy hypoxic-ischemic reperfusion brain injury mitochondria model proteomic analysis REPERFUSION Rice-Vannucci transmission electron microscopy 
The critical role of the endolysosomal system in cerebral ischemia被引量：3
《Neural Regeneration Research》2023年第5期983-990,共8页Hui-Yi Zhang Ye Tian Han-Yan Shi Ya Cai Ying Xu 
supported the National Natural Science Foundation of China,No. 81970760 (to YT);the Natural Science Foundation of Liaoning Province,No. 2021-MS-201 (to YX);the 345 Talent Project of Shengjing Hospital of China Medical University,No. M0370 (to YT);the 345 Talent Project of Shengjing Hospital of China Medical University,No. M0395 (to YX)。
Cerebral ischemia is a serious disease that triggers sequential pathological mechanisms, leading to significant morbidity and mortality. Although most studies to date have typically focused on the lysosome, a single o...
关键词：AUTOPHAGY biodegradation brain injury chaperone-mediated autophagy endolysosomal system fusion HYPOXIA-ISCHEMIA brain mitophagy N-ethylmaleimide-sensitive protein TMEM175 
The delivery of miR-21a-5p by extracellular vesicles induces microglial polarization via the STAT3 pathway following hypoxia-ischemia in neonatal mice被引量：4
《Neural Regeneration Research》2022年第10期2238-2246,共9页Dan-Qing Xin Yi-Jing Zhao Ting-Ting Li Hong-Fei Ke Cheng-Cheng Gai Xiao-Fan Guo Wen-Qiang Chen De-Xiang Liu Zhen Wang 
supported by the National Natural Science Foundation of China,Nos.81873768,82072535,81671213(to ZW),81770436(to WQC);the National Key Project of Chronic Non-Communicable Disease of China,No.2016YFC1300403(to WQC).
Extracellular vesicles(EVs)from mesenchymal stromal cells(MSCs)have previously been shown to protect against brain injury caused by hypoxia-ischemia(HI).The neuroprotective effects have been found to relate to the ant...
关键词：extracellular vesicles HYPOXIA-ISCHEMIA mesenchymal stromal cells MICROGLIA miR-21a-5p NEUROINFLAMMATION oxygen-glucose deprivation STAT3 
Corrigendum: Offspring of rats with cerebral hypoxia-ischemia manifest cognitive dysfunction in learning and memory abilities
《Neural Regeneration Research》2022年第2期265-265,共1页
In“Offspring of rats with cerebral hypoxia-ischemia manifest cognitive dysfunction in learning and memory abilities”,which was published on pages 1662-1670,Issue 9,Volume 15 of Neural Regeneration Research(Xue et al...
关键词：CEREBRAL ischemia RATS 
Brain-derived neurotrophic factor and its related enzymes and receptors play important roles after hypoxic-ischemic brain damage被引量：16
《Neural Regeneration Research》2021年第8期1453-1459,共7页Liu-Lin Xiong Jie Chen Ruo-Lan Du Jia Liu Yan-Jun Chen Mohammed Al Hawwas Xin-Fu Zhou Ting-Hua Wang Si-Jin Yang Xue Bai 
supported by the National Natural Science Foundation of China,No. 82001604 (to LLX);the Joint Subject of Southwest Medical University and Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University of China,No. 2018XYLH-004 (to LLX);the National Construction Project of Regional Chinese Medicine Treatment Centre of China,No. 2018205 (to XB);the National Construction Project of the Second Clinical Research Base of Chinese Medicine of China,No. 2018131 (to XB)。
Brain-derived neurotrophic factor(BDNF) regulates many neurological functions and plays a vital role during the recovery from central nervous system injuries. However, the changes in BDNF expression and associated fac...
关键词：brain injury brain-derived neurotrophic factor ENZYME HYPOXIA-ISCHEMIA RECEPTORS recovery repair 
Role of apoptosis-inducing factor in perinatal hypoxic-ischemic brain injury被引量：18
《Neural Regeneration Research》2021年第2期205-213,共9页Juan Rodriguez Tao Li Yiran Xu Yanyan Sun Changlian Zhu 
the Swedish Research Council(2018-02667);the National Natural Science Foundation of China(31761133015,U1704281,81901335);the Swedish Childhood Cancer Foundation(PR2018-0082);Swedish Governmental Grants to Scientists Working in Health Care(ALFGBG-717791);the Swedish Brain Foundation(FO2018-0034);the Chinese Scholarship Council to TL(201707040025)and to YX(201507040082)。
Perinatal complications,such as asphyxia,can cause brain injuries that are often associated with subsequent neurological deficits,such as cerebral palsy or mental retardation.The mechanisms of perinatal brain injury a...
关键词：apoptosis apoptosis inducing factor ASPHYXIA cell death free radical HYPOXIA-ISCHEMIA mitochondria NEONATES oxidative stress 
Offspring of rats with cerebral hypoxia-ischemia manifest cognitive dysfunction in learning and memory abilities被引量：5
《Neural Regeneration Research》2020年第9期1662-1670,共9页Lu-Lu Xue Fang Wang Rui-Ze Niu Ya-Xin Tan Jia Liu Yuan Jin Zheng Ma Zi-Bin Zhang Ya Jiang Li Chen Qing-Jie Xia Jun-Jie Chen Ting-Hua Wang Liu-Lin Xiong 
supported by the National Natural Science Foundation of China,No.81560215(FW);the Innovative Research Team Program of Science and Technology in Yunnan Province of China,No.2017HC007
Neonatal hypoxic-ischemic encephalopathy is a serious neurological disease,often resulting in long-term neurodevelopmental disorders among surviving children.However,whether these neurodevelopmental issues can be pass...
关键词：cerebral atrophy cerebral infarct cerebral liquefaction cognitive impairment magnetic resonance imaging neonatal brain hypoxia and ischemia neuronal apoptosis OFFSPRING 
Hypoxia-ischemia in the immature rodent brain impairs serotonergic neuronal function in certain dorsal raphé nuclei
《Neural Regeneration Research》2020年第3期457-463,共7页Hanna E.Reinebrant Julie A.Wixey Kathryn M.Buller 
funded by the National Health and Medical Research Council of Australia(to KMB);HER was supported by a University of Queensland International Research Tuition Award and University of Queensland Research Scholarship.JAW was supported by an Australian Postgraduate Award
Neonatal hypoxia-ischemia(HI) results in losses of serotonergic neurons in specific dorsal raphé nuclei. However, not all serotonergic raphé neurons are lost and it is therefore important to assess the function of r...
关键词：dorsal raphé nuclei Fos HYPOXIA-ISCHEMIA NEONATE newborn brain injury PRETERM restraint stress serotonin 
Transfer of mitochondria from mesenchymal stem cells derived from induced pluripotent stem cells attenuates hypoxia-ischemia-induced mitochondrial dysfunction in PC12 cells被引量：9
《Neural Regeneration Research》2020年第3期464-472,共9页Yan Yang Gen Ye Yue-Lin Zhang Hai-Wei He Bao-Qi Yu Yi-Mei Hong Wei You Xin Li 
supported by the National Natural Science Foundation of China,No.81671882,81471832;the Natural Science Foundation of Guangdong Province of China,No.2016A030311039;the Science and Technology Foundation of Guangdong Province of China,No.2015A020212012,2017A020224012;the Science and Technology Foundation of Guangzhou City of China,No.201707010373(all to XL)
Mitochondrial dysfunction in neurons has been implicated in hypoxia-ischemia-induced brain injury.Although mesenchymal stem cell therapy has emerged as a novel treatment for this pathology,the mechanisms are not fully...
关键词：apoptosis brain injury HYPOXIA-ISCHEMIA INDUCED pluripotent STEM CELLS mesenchymal STEM CELLS MITOCHONDRIAL membrane potential MITOCHONDRIAL TRANSFER PC12 CELLS tunneling nanotubes 
Can we further optimize therapeutic hypothermia for hypoxic-ischemic encephalopathy?被引量：24
《Neural Regeneration Research》2019年第10期1678-1683,共6页Anthony Davies Guido Wassink Laura Bennet Alistair J.Gunn Joanne O.Davidson 
supported by The Health Research Council of New Zealand(grant No.16/003,17/601);the Marsden Fund(grant No.17-UOA232);a Sir Charles Hercus Fellowship from the Health Research Council of New Zealand(grant No.16/003)
Perinatal hypoxic-ischemic encephalopathy is a leading cause of neonatal death and disability.Therapeutic hypothermia significantly reduces death and major disability associated with hypoxic-ischemic encephalopathy;ho...
关键词：HYPOXIA-ISCHEMIA hypoxic-ischemic ENCEPHALOPATHY THERAPEUTIC HYPOTHERMIA neuroprotection THERAPEUTIC strategies randomized controlled trials animal models fetal sheep PIGLETS 
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