PARKINSONS_DISEASE

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Melatonin Ameliorates Abnormal Sleep-Wake Behavior via Facilitating Lipid Metabolism in a Zebrafish Model of Parkinson’s Disease
《Neuroscience Bulletin》2024年第12期1901-1914,共14页Meng-Zhu Pang Han-Xing Li Xue-Qin Dai Xiao-Bo Wang Jun-Yi Liu Yun Shen Xing Xu Zhao-Min Zhong Han Wang Chun-Feng Liu Fen Wang 
supported by the National Natural Science Foundation of China(82071420,82471269);Science and Technology Innovation Project of Xiongan New Area(2023XAGG0073);Jiangsu Provincial Medical Key Discipline(ZDXK202217);Suzhou Technology Development Program(SLJ2021010);Suzhou Key Laboratory(SZS2023015).
Sleep-wake disorder is one of the most common nonmotor symptoms of Parkinson's disease(PD).Melatonin has the potential to improve sleep-wake disorder,but its mechanism of action is still unclear.Our data showed that m...
关键词：ZEBRAFISH MELATONIN Melatonin receptor 1 Parkinson’s disease Sleep-wake disorder Lipid metabolism 
Positron Emission Tomography Imaging of Synaptic Dysfunction in Parkinson’s Disease
《Neuroscience Bulletin》2024年第6期743-758,共16页Jiaqi Niu Yan Zhong Chentao Jin Peili Cen Jing Wang Chunyi Cui Le Xue Xingyue Cui Mei Tian Hong Zhang 
supported by the National Key Research and Development Program of China(2022YFC2009900,2021YFE0108300,2022YFE0118000,and 2021YFA1101700);the National Natural Science Foundation of China(82030049);Fundamental Research Funds for the Central Universities of China.
Parkinson’s disease(PD)is one of the most common neurodegenerative diseases with a complex pathogenesis.Aggregations formed by abnormal deposition of alpha-synuclein(αSyn)lead to synapse dysfunction of the dopamine ...
关键词：Parkinson’s disease Positron emission tomography Synapse dysfunction ALPHA-SYNUCLEIN Dopamine system Non-dopamine system 
Relationship Between Short-chain Fatty Acids and Parkinson’s Disease:A Review from Pathology to Clinic被引量：1
《Neuroscience Bulletin》2024年第4期500-516,共17页Wen-Xiang Duan Fen Wang Jun-Yi Liu Chun-Feng Liu 
supported by the Jiangsu Provincial Key R&D Program(BE2018658);Jiangsu Provincial Medical Key Discipline(ZDXK202217);the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).
Parkinson’s disease(PD)is a complicated neurodegenerative disease,characterized by the accumulation ofα-synuclein(α-syn)in Lewy bodies and neurites,and massive loss of midbrain dopamine neurons.Increasing evidence ...
关键词：Parkinson’s disease Short-chain fatty acids Microbial metabolites Brain-gut-microbiota axis 
Spatial Distribution of Parvalbumin-Positive Fibers in the Mouse Brain and Their Alterations in Mouse Models of Temporal Lobe Epilepsy and Parkinson’s Disease
《Neuroscience Bulletin》2023年第11期1683-1702,共20页Changgeng Song Yan Zhao Jiajia Zhang Ziyi Dong Xin Kang Yuqi Pan Jinle Du Yiting Gao Haifeng Zhang Ye Xi Hui Ding Fang Kuang Wenting Wang Ceng Luo Zhengping Zhang Qinpeng Zhao Jiazhou Yang Wen Jiang Shengxi Wu Fang Gao 
supported by the Ministry of Science and Technology of China(2021ZD0201005);the National Natural Science Foundation of China(82071529 and 81974204);the Key R&D Program of Shaanxi Province(2021SF-238).
Parvalbumin interneurons belong to the major types of GABAergic interneurons.Although the distribution and pathological alterations of parvalbumin interneuron somata have been widely studied,the distribution and vulne...
关键词：alterations EPILEPSY fibers 
Correction:Spatial Distribution of Parvalbumin‑Positive Fibers in the Mouse Brain and Their Alterations in Mouse Models of Temporal Lobe Epilepsy and Parkinson’s Disease
《Neuroscience Bulletin》2023年第11期1747-1748,共2页Changgeng Song Yan Zhao Jiajia Zhang Ziyi Dong Xin Kang Yuqi Pan Jinle Du Yiting Gao Haifeng Zhang Ye Xi Hui Ding Fang Kuang Wenting Wang Ceng Luo Zhengping Zhang Qinpeng Zhao Jiazhou Yang Wen Jiang Shengxi Wu Fang Gao 
In this article the wrong figure appeared as Fig.3,the figure should have appeared as shown below.
关键词：Spatial FIGURE appeared 
Altered Motor Performance,Sleep EEG,and Parkinson’s Disease Pathology Induced by Chronic Sleep Deprivation in Lrrk2^(G2019S) Mice被引量：3
《Neuroscience Bulletin》2022年第10期1170-1182,共13页Xinyao Liu Hang Yu Yuanyuan Wang Song Li Cheng Cheng Murad Al-Nusaif Weidong Le 
We thank Liaoning Provincial Center for Clinical Research on Neurological Diseases,the First Affiliated Hospital,and Dalian Medical University for the research infrastructure and support.This work was supported by the National Natural Science Foundation of China(81771521).
Parkinson’s disease(PD)is a multifaceted disease in which environmental variables combined with genetic predisposition cause dopaminergic(DAergic)neuron loss in the substantia nigra pars compacta.The mutation of leuc...
关键词：Parkinson’s disease Sleep disturbance Lrrk2^(G2019S)mutation ELECTROENCEPHALOGRAM NEURODEGENERATION 
Calcium Homeostasis in Parkinson’s Disease:From Pathology to Treatment被引量：1
《Neuroscience Bulletin》2022年第10期1267-1270,共4页Jingxian Zhang Qingqing Shen Yue Ma Lin Liu Wenting Jia Leilei Chen Junxia Xie 
This insight was supported by the National Foundation of Natural Science of China(32170984);the Natural Science Foundation of Shandong Province(ZR2020YQ23 and ZR2019BC008).
Disturbances of Ca^(2+)homeostasis have been reported to be associated with the development of Parkinson's disease(PD)(Fig.1),which is characterized by the selective vulnerability of dopaminergic neurons in the substa...
关键词：HOMEOSTASIS STASIS capacity. 
Targeting the Cuneiform Nucleus in Parkinson’s Disease: Option to Improve Locomotor Activity被引量：1
《Neuroscience Bulletin》2022年第8期976-978,共3页Wei Cui Bao Xue Junxia Xie Huamin Xu 
This Highlight was supported by the National Natural Science Foundation of China(31871202,32170984);the Department of Science and Technology of Shandong Province(ZR2019MC057);Excellent Innovative Team of Shandong Province(2020KJK007);Taishan Scholars Construction Project of Shandong Province,China.
Parkinson's disease(PD)is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta(SNpc),accompanied by severe locomotor deficits[1].Deep brain stimulation(DBS)mainly targeting the subth...
关键词：STIMULATION FREEZING clinically 
Hot Topics in Recent Parkinson’s Disease Research:Where We are and Where We Should Go被引量：6
《Neuroscience Bulletin》2021年第12期1735-1744,共10页Song Li Congcong Jia Tianbai Li Weidong Le 
the National Key Research and Development Program of China(2016YFC1306600);the National Natural Science Foundation of China(82001483);the Guangdong Provincial Key R&D Program(2018B030337001).
Parkinson’s disease(PD),the second most common neurodegenerative disease,is clinically characterized by both motor and non-motor symptoms.Although overall great achievements have been made in elucidating the etiology...
关键词：Parkinson’s disease Gut-brain axis Biomarkers NEUROINFLAMMATION Sleep disorder Genetics Ferroptosis 
Co-editing PINK1 and DJ-1 Genes Via Adeno-Associated Virus-Delivered CRISPR/Cas9 System in Adult Monkey Brain Elicits Classical Parkinsonian Phenotype被引量：8
《Neuroscience Bulletin》2021年第9期1271-1288,共18页Hao Li Shihao Wu Xia Ma Xiao Li Tianlin Cheng Zhifang Chen Jing Wu Longbao Lv Ling Li Liqi Xu Wenchao Wang Yingzhou Hu Haisong Jiang Yong Yin Zilong Qiu Xintian Hu 
This work was supported by the National Key R&D Program of China(2018YFA0801403);the Key-Area Research and Development Program of Guangdong Province(2019B030335001);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32060200);the National Program for Key Basic Research Projects(973 Program:2015CB755605);the National Natural Science Foundation of China(81471312,81771387,81460352,81500983,31700897,31700910,31800901,31625013,and 91732302);the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province(2017FB109,2018FB052,2018FB053,2019FA007,and 202001AT070130);Chinese Academy of Sciences"Light of West China"Program,Shanghai Brain-Intelligence Project from Science and Technology Commission of Shanghai Municipality(16JC1420501);Shanghai Municipal Science and Technology Major Project(2018SHZDZX05);Open Large Infrastructure Research of Chinese Academy of Sciences,and China Postdoctoral Science Foundation(2018M631105).
Whether direct manipulation of Parkinson’s disease(PD)risk genes in the adult monkey brain can elicit a Parkinsonian phenotype remains an unsolved issue.Here,we used an adeno-associated virus serotype 9(AAV9)-deliver...
关键词：Parkinson’s disease MONKEY Adeno-associated virus-delivered CRISPR/Cas9 PINK1 DJ-1 Parkinsonian phenotype 
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