supported by the National Natural Science Foundation of China,Nos.82072165 and 82272256(both to XM);the Key Project of Xiangyang Central Hospital,No.2023YZ03(to RM)。
Spinal cord injury represents a severe form of central nervous system trauma for which effective treatments remain limited.Microglia is the resident immune cells of the central nervous system,play a critical role in s...
supported by the National Natural Science Foundation of China,No.81971031(to ZL);the National Key Research and Development Program of China,No.2022YFE0210100(to JFC);the National Natural Science Foundation of China(Original Exploration Project),No.82151308(to JFC);the National Natural Science Foundation of China(Research Fund for International Senior Scientists),No.82150710558(to JFC);Science&Technology Initiative STI2030-Major Projects,No.2021ZD0203400(to JFC);Key Research and Development Program of Zhejiang Province,No.2023C03079(to JFC);Scientific Research Starting Foundation of Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine,Vision and Brain Health),No.OJQDSP2022007(to JFC);Project of State Key Laboratory of Ophthalmology,Optometry and Visual Science,Wenzhou Medical University,No.J01-20190101(to JFC);Scientific Research Starting Foundation of Wenzhou Medical University,No.QTJ12003(to JFC);Department of Science and Technology of Zhejiang Province,No.2023ZY1011(to JFC)。
The excessive buildup of neurotoxicα-synuclein plays a pivotal role in the pathogenesis of Parkinson's disease,highlighting the urgent need for innovative therapeutic strategies to promoteα-synuclein clearance,parti...
supported by The Basic Science Research Program through the National Research Foundation of Korea(NRF);funded by the Ministry of Education(RS-2023-00244901)(to RB)。
Challenges in the prevention and treatment of mild cognitive impairment associated with Alzheimer's disease:Increased life expectancy due to advancements in medical care has given rise to an aging population,accompani...
supported by the German Research Foundation(grants 514990328,389030878,405358801/428817542(within FOR2879)and 449437943(within TRR332,project C06);German Federal Ministry of Education and Science(3DOS,grant 161L0278B)(to DMH)。
Extracellular vesicles(EVs)are cell-derived,lipid membrane-enclosed vesicles carrying a broad spectrum of biologically active molecules(including proteins,RNAs,and bioactive lipids)which play important roles in interc...
supported by a grant from the French Multiple Sclerosis Society(ARSEP,Grant Number:R20163LL)(to AMG)。
Multiple sclerosis(MS)is the most common chronic disease of the central nervous system(CNS)in young adults and represents the first cause of severe handicap,originally non-traumatic(Oh et al.,2018).MS is chara cterize...
supported by the National Natural Science Foundation of China,Nos.82271411(to RG),51803072(to WLiu);grants from the Department of Finance of Jilin Province,Nos.2022SCZ25(to RG),2022SCZ10(to WLiu),2021SCZ07(to RG);Jilin Provincial Science and Technology Program,No.YDZJ202201ZYTS038(to WLiu);The Youth Support Programmed Project of China-Japan Union Hospital of Jilin University,No.2022qnpy11(to WLuo);The Project of China-Japan Union Hospital of Jilin University,No.XHQMX20233(to RG)。
Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular mechanisms.Past studies have focused on factors that stimulat...
The adult mammalian central nervous system(CNS) coordinates essential functions such as sensation,movement,autonomic control,thought processes,and communication.Consequently,injuries or diseases of the CNS are often a...
supported by the Spanish Ministerio de Ciencio,Innovoción y Universidades(grant number RTI-2018-099908-B-C21 and RTI-2018-099908-B-C22 granted to CC);by the Consejería de Economia,Conocimiento,Empresas y Universidades(grant number FEDERUCA18-106647 granted to CC);by the Consejería de Salud y Familias 80%co-financed by EDRFITI regional funds(ITI-Cadiz-0042-2019 to CC)。
Tissue regeneration maintains homeostasis and preserves the functional features of each tissue.However,not all tissues show a strong repairing capacity.This is the case of the central nervous system.It is now well est...
supported by the National Natural Science Foundation of China,No.81771351;the National Key R&D Program of China,No.2017YFA0105802;the Joint Research Fund Liaoning-Shenyang National Laboratory for Materials Science,No.2019JH3/30100022;the National Science Foundation for Post-doctoral Scientists of China,No.2018M641732(all to QA and LLW)。
The functional properties of endogenous Schwann cells(SCs)during nerve repair are dynamic.Optimizing the functional properties of SCs at different stages of nerve repair may have therapeutic benefit in improving the r...
supported by the National Natural Science Foundation of China, No. 31671248;the Natural Science Foundation of Beijing, No. 7222198 (both to NH)
We previously combined reduced graphene oxide(rGO)with gelatin-methacryloyl(GelMA)and polycaprolactone(PCL)to create an rGO-GelMA-PCL nerve conduit and found that the conductivity and biocompatibility were improved.Ho...