THYMOSIN

作品数:36被引量:164H指数:6
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相关领域:医药卫生更多>>
相关作者:张伟李春义褚文辉路晓董振更多>>
相关机构:中国农业科学院特产研究所长春中医药大学东南大学南开大学更多>>
相关期刊:《Journal of Southeast University(English Edition)》《中国继续医学教育》《World Journal of Neuroscience》《Acta Oceanologica Sinica》更多>>
相关基金:国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划中央级公益性科研院所基本科研业务费专项更多>>
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Hypermethylation of thymosinβ4 predicts a poor prognosis for patients with acute-on-chronic hepatitis B liver failure
《Hepatobiliary & Pancreatic Diseases International》2023年第4期373-382,共10页He Wang Yan-Ping Yin Zhen-Li Wang Yu Qian Yu-Chen Fan Hui-Hui Liu Kai Wang 
supported by grants from the Key Project of the Chinese Ministry of Science and Technology(2017ZX102022022);the National Natural Science Foundation of China(81970522);the Key Research and Development Project of Shandong Province(2019GSF108023).
Background:It has been demonstrated that thymosinβ4(Tβ4)could inflect the severity of acute-on-chronic hepatitis B liver failure(ACHBLF),but the relationship between its methylation status and the prognosis of liver...
关键词:Acute-on-chronic hepatitis B liver failure Acute-on-chronic hepatitis B pre-liver failure Thymosinβ4 METHYLATION PROGNOSIS 
Impact of thymosinα1 as an immunomodulatory therapy on long-term survival of non-small cell lung cancer patients after R0 resection:a propensity score-matched analysis被引量:4
《Chinese Medical Journal》2021年第22期2700-2709,共10页Cheng-Lin Guo Jian-Dong Mei Yu-Long Jia Fan-Yi Gan Yu-Dong Tang Cheng-Wu Liu Zhen Zeng Zhen-Yu Yang Sen-Yi Deng Xing Sun Lun-Xu Liu 
1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University(Nos.ZYGD18021 and ZYJC18009).
Background:There is limited information about thymosinα1(Tα1)as adjuvant immunomodulatory therapy,either used alone or combined with other treatments,in patients with non-small cell lung cancer(NSCLC).This study aim...
关键词:Non-small cell lung cancer RESECTION Adjuvant therapy Thymosinα1 
Thymosin as a possible therapeutic drug for COVID-19:A case report
《World Journal of Clinical Cases》2021年第16期4090-4094,共5页Qiong Na Zheng Mei Yan Xu Fang Min Gan Sha Sha Ye Hui Zhao 
The Project for Science and Technology of Wenzhou,No.Y2020278.
BACKGROUND There are no effective antiviral therapies for coronavirus disease 2019(COVID-19)at present.Although most patients with COVID-19 have a mild or moderate course of disease,up to 5%-10%of patients may have a ...
关键词:COVID-19 THYMOSIN SARS-CoV-2 Treatment Therapeutic drug Case report 
The severe COVID-19: A sepsis induced by viral infection? And its immunomodulatory therapy被引量:9
《Chinese Journal of Traumatology》2020年第4期190-195,共6页Hong-Yuan Lin 
COVID-19 is known for its magical infectivity,fast transmission and high death toll based on the large number of infected people.From the perspective of the clinical manifestation,autopsy examination and pathophysiolo...
关键词:COVID-19 SEPSIS Immunomodulatory therapy IMMUNOTHERAPY ULINASTATIN Thymosin a1 
斑节对虾胸腺素β5的克隆、表达与功能分析被引量:1
《中国水产科学》2020年第4期383-392,共10页陈鸣 赵超 范嗣刚 王鹏飞 闫路路 王芳 邱丽华 
国家重点研发计划专项(2018YFD0900303);海南省自然科学基金项目(319QN335);中央级公益性科研院所基本科研业务费专项(2018HY-ZD0204);海南省重点研发计划项目(ZDYF2018163);广东省促进经济发展专项(GDOE[2019]A24).
β-胸腺素(β-thymosin)是一类高度保守的功能多肽,在伤口愈合、血管生成、抗菌和抗病毒免疫等生理活动中起重要的调控作用。本研究从斑节对虾(Penaeus monodon)中成功克隆了一种β-thymosin cDNA序列(β-thymosin 5),其全长为1495 bp,...
关键词:斑节对虾 β-thymosin 基因表达 原核表达 抗菌活性 
Thymosin Alpha-1 Inhibits Complete Freund’s Adjuvant-Induced Pain and Production of Microglia-Mediated Pro-inflammatory Cytokines in Spinal Cord被引量:5
《Neuroscience Bulletin》2019年第4期637-648,共12页Yunlong Xu Yanjun Jiang Lin Wang Jiahua Huang Junmao Wen Hang Lv Xiaoli Wu Chaofan Wan Chuanxin Yu Wenjie Zhang Jiaying Zhao Yinqi Zhou Yongjun Chen 
supported by the Foundation for Distinguished Young Talents in Higher Education of Guangdong Province, China (2016KQNCX019 and 2016KQNCX027);the National Natural Science Foundation of China (31571041);the Guangdong Provincial Department of Education Innovating Strong National Engineering Major Project (2014GKXM031);Guangdong Provincial Universities and Colleges Pearl River Scholar Funded Scheme (2016)
Activation of inflammatory responses regulates the transmission of pain pathways through an integrated network in the peripheral and central nervous systems.The immunopotentiator thymosin alpha-1(Tal)has recently been...
关键词:THYMOSIN alpha-1 Cytokine MICROGLIA Vesicular GLUTAMATE TRANSPORTER type 2 Vesicular γ-aminobutyric acid TRANSPORTER 
梅花鹿Thymosin beta 10基因的原核表达、活性鉴定和多克隆抗体制备
《中国农业大学学报》2018年第11期72-79,共8页褚文辉 张伟 赵海平 王大涛 李春义 
吉林省自然科学基金项目(20170101032JC;20170101003JC);中央级公益性科研院所基本科研业务费专项(1610342018028)
为研究梅花鹿Thymosin beta 10基因(Tβ10)在鹿茸快速生长过程中的作用,利用Gateway技术构建梅花鹿Tβ10基因的原核表达载体—pDEST17-Tβ10并诱导表达,对融合蛋白进行功能检测及多克隆抗体制备。结果表明:1)获得了190bp Tβ10基因开放...
关键词:梅花鹿 THYMOSIN BETA 10 原核表达 鹿茸 多克隆抗体 
Effect of ulinastatin + thymosin adjuvant therapy on inflammatory and stress response in patients with severe pneumonia
《Journal of Hainan Medical University》2017年第24期41-44,共4页Jiang Wang Ya-Dong Yang Qiu-Fang She Gui-Fen Chen 
Objective: To investigate the effect of ulinastatin + thymosin adjuvant therapy on inflammatory and stress response in patients with severe pneumonia. Methods: A total of 66 patients with severe pneumonia who were dia...
关键词:SEVERE PNEUMONIA ULINASTATIN THYMOSIN INFLAMMATORY factor Stress HORMONE 
Potential role of thymosin beta 4 in the treatment of nonalcoholic fatty liver disease被引量:4
《Chronic Diseases and Translational Medicine》2017年第3期165-168,共5页Yong Jiang Tao Han Zhi-Guang Zhang Man Li Feng-Xiang Qi Ying Zhang Ying-Lan Ji 
As a result of increased prevalence of obesity worldwide, non-alcoholic fatty liver disease (NAFLD) has become one of the most common causes of chronic liver disease. Although most NAFLD cases remain benign, some prog...
关键词:Thymosin beta 4 Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis HYPOTHESIS 
Recombinant adeno-associated virus carrying thymosin β4 suppresses experimental colitis in mice被引量:6
《World Journal of Gastroenterology》2017年第2期242-255,共14页Xiao-Yan Zheng Yi-Fei Lv Shuang Li Qian Li Qian-Nan Zhang Xue-Ting Zhang Zhi-Ming Hao 
Supported by National Foundation of Natural Sciences,China,No.81300293
AIMTo investigate the protective effect of a recombinant adeno-associated virus carrying thymosin β4 (AAV-Tβ4) on murine colitis via intracolonic administration.METHODSAAV-T...
关键词:Thymosin β 4 MICE COLITIS Dextran sulfate sodium 2 4 6-trinitrobenzene sulfonic acid 
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