supported by grants from the Ministry of Science and Technology of China(2021ZD0203204);the National Natural Science Foundation of China(32030052 and 31530028).
Sleep deprivation has been shown to exacerbate pain sensitivity and may contribute to the onset of chronic pain,yet the precise neural mechanisms underlying this association remain elusive.In our study,we explored the...
supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32030200);the National Natural Science Foundation of China(31070935 and 62173326);the National Basic Research Program of China(2013CB835100);the Youth Innovation Promotion Association,CAS(2022367)。
Acetylcholine(ACh)is an important neuromod-ulator in various cognitive functions.However,it is unclear how ACh influences neural circuit dynamics by altering cellular properties.Here,we investigated how ACh influ-ence...
supported by grants from National Natural Science Foundation of China(82071508,31771190,31730035).
Malfunction of the ventral subiculum(vSub),the main subregion controlling the output connections from the hippocampus,is associated with major depressive disorder(MDD).Although the vSub receives cholinergic innervatio...
Schizophrenia is a common and severe mental disorder with a lifetime prevalence of~1%[1]Apart from the typical positive symptoms,such as hallucinations and delusions,which mainly make patients seek medication,60%-70%o...
This work was supported by grants from the Foundation of Health and Family Planning Commission of Hubei Province,China(WJ2018H0074);the National Natural Science Foundation of China(61721092,81670240 and 81873467).
Dear Editor,The cholinergic system plays an important role in regulating locomotion and motor functions by modulating neuronal activity[1].However,the anatomical relationships between the brain-wide cholinergic system...
supported by grants from the National Natural Science Foundation of China(81770293 and 81473203)
Cardiovascular diseases are life-threatening illnesses with high morbidity and mortality. Suppressed vagal(parasympathetic) activity and increased sympathetic activity are involved in these diseases. Currently, pharma...
supported by the National Natural Science Foundation of China(81470534,81770419,81630012,and 81570385);the Key Laboratory of Medical Electrophysiology(Southwest Medical University);Ministry of Education of China-No201709(KeyME-2017-09)
The rostral ventrolateral medulla(RVLM) is a key region in cardiovascular regulation. It has been demonstrated that cholinergic synaptic transmission in the RVLM is enhanced in hypertensive rats. Angiotensinconverting...
supported by grants from the National Institutes of Health,USA(R01AG038710,R01AG021173,R01AG044420 and R01NS046673);the Alzheimer’s Association,the National Natural Science Foundation of China(91332112,81225008 and 81161120496);Fundamental Research Funds for the Central Universities of China;the Fok Ying Tung Education Foundation
The degeneration of cholinergic neurons and cholinergic hypofunction are pathologies associated with Alzheimer's disease (AD). Muscarinic acetylcholine receptors (mAChRs) mediate acetylcholine-induced neurotransm...
supported by grants from the Department of Health of Heilongjiang Province, China (2006-228);the Educational Commission of Heilongjiang Province, China(11531096);the National Natural Science Foundation of China (31100819, 30970980);the Natural Science Foundation of Guangdong Province, China (S2011040002239);the China Postdoctoral Science Foundation (2010-0480805)
Objective Decline, disruption, or alterations of nicotinic cholinergic mechanisms contribute to cognitive dysfunctions like Alzheimer's disease (AD). Although amyloid-β (Aβ) aggregation is a pathological hallma...
Objective To establish an artificial somatic-autonomic reflex arc in rats and observe the following distributive changes of neural fibers in the bladder. Methods Adult Sprague-Dawley rats were randomly divided into th...