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  • 期刊=Neural Regeneration Researchx
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Next generation drug connectivity mapping for acquiring therapeutic agents to differentially regulate myelination
《Neural Regeneration Research》2023年第4期797-798,共2页Kasum Azim Andrea Domenico Rivera Arthur Morgan Butt 
The need for new therapeutic approaches:Conventional drug discovery is a lengthy and expensive process,taking decades and billions of dollars to get a drug from bench to bedside.Much of the costs incurred are at the p...
关键词：CONNECTIVITY DOLLAR THERAPEUTIC 
Microtubule affinity regulating kinase(MARK/Par1)isoforms differentially regulate Alzheimer-like TAU missorting and Aβ-mediated synapse pathology被引量：1
《Neural Regeneration Research》2023年第2期335-336,共2页Jana Chudobová Hans Zempel 
supported by the Koeln Fortune Program/Faculty of Medicine,University of Cologne,the Else-Kr?ner-Fresenius-Stiftung。
Importance of TAU protein for dementia syndromes:Dementia currently affects about 55 million people worldwide,with Alzheimer's disease(AD)being the most prevalent form.The one crucial pathological hallmark of AD that ...
关键词：ALZHEIMER diseases 
Identification of microRNAs and messenger RNAs involved in human umbilical cord mesenchymal stem cell treatment of ischemic cerebral infarction using integrated bioinformatics analysis被引量：14
《Neural Regeneration Research》2019年第9期1610-1616,共7页Yin-Meng Qu Xin Sun Xiu-Li Yan Hang Jin Zhen-Ni Guo Yi Yang 
supported by the National Key Research&Development Program of China,No.2016YFC1301600;Program for Jilin University Science and Technology Innovation Team,No.2017TD-12(both to YY)
In recent years,a large number of differentially expressed genes have been identified in human umbilical cord mesenchymal stem cell(hUMSC)transplants for the treatment of ischemic cerebral infarction.These genes are i...
关键词：nerve REGENERATION ischemic cerebral infarction human umbilical cord mesenchymal STEM CELL TREATMENT bioinformatics analysis DIFFERENTIALLY EXPRESSED genes DIFFERENTIALLY EXPRESSED mRNAs inflammatory response STEM CELL therapy weighted gene co-suppression analysis WGCNA protein-protein interaction network PPI hUMSC neural REGENERATION 
High-throughput sequencing analysis of differentially expressed mi RNAs and target genes in ischemia/reperfusion injury and apelin-13 neuroprotection
《Neural Regeneration Research》2018年第2期265-271,共7页Chun-mei Wang Xue-lu Yang Ming-hui Liu Bao-hua Cheng Jing Chen Bo Bai 
supported by the National Natural Science Foundation of China,No.81501018 and 816712276;the Natural Science Foundation of Shandong Province of China,No.ZR2013CQ031 and ZR2014HL040
miRNAs regulate a variety of biological processes through pairing-based regulation of gene expression at the 3＇ end of the noncoding region of the target miRNA, miRNAs were found to be abnormally expressed in ischemi...
关键词：nerve regeneration RNA sequencing microRNA APELIN ischemia/reperfusion injury NEUROPROTECTION NEUROPEPTIDE high-throughput sequencing neural regeneration 
Differential temporal expression of matrix metalloproteinases following sciatic nerve crush被引量：5
《Neural Regeneration Research》2016年第7期1165-1171,共7页Jing Qin Guang-bin Zha Jun Yu Hong-hong Zhang Sheng Yi 
supported by the Natural Science Foundation of Jiangsu Province of China,No.BK20150409;the Natural Science Foundation of Jiangsu Higher Education Institutions of China,No.15KJB180013;the Scientific Research Foundation of Nantong University in China,No.14R29;the Natural Science Foundation of Nantong City in China,No.MS12015043;the Priority Academic Program Development of Jiangsu Higher Education Institutions in China
We previously performed transcriptome sequencing and found that genes for matrix metalloproteinases（MMPs）,such as MMP7 and 12,seem to be highly upregulated following peripheral nerve injury,and may be involved in ne...
关键词：sequencing crush systematically regeneration verified repair TIMP differentially enriched degrade 
P75 and phosphorylated c-Jun are differentially regulated in spinal motoneurons following axotomy in rats
《Neural Regeneration Research》2012年第26期2005-2011,共7页Qiuju Yuan Huanxing Su Wutian Wu Zhi-Xiu Lin 
supported by Direct Grant (Project No.2030392) of the Chinese University of Hong Kong;HK Spinal Cord Injury Foundation;National Key Basic Research Support Foundation (973 Project: 2011CB504402)
The neurotrophin receptor （p75） activates the c-Jun N-terminal kinase （JNK） pathway. Activation of JNK and its substrate c-Jun can cause apoptosis. Here we evaluate the role of p75 in spinal motoneurons by compari...
关键词：apoptosis transcription factor c-Jun N-terminal kinase nerve growth factor receptor MOTONEURON spinal cord AXOTOMY NEONATAL adult axonal regeneration 
Using Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry to analyze differentially expressed brain polypeptides in scrapie strain 22L-infected BALB/c mice被引量：1
《Neural Regeneration Research》2011年第23期1801-1805,共5页Xiangyu Liao Jiayu Wan Wensen Liu Xin Tang Wufei Zhu Na XU Jing Xu Nan Li Yaping Chang Chuanjing Ju 
the National Natural Science Foundation of China,No. 30972197 and 31072148;Science and Technology Plan Program of Jilin Province,No. 201105038
Differentialiy expressed polypeptides in the brain of a BALB/c mouse model infected with scrapie strain 22L were analyzed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The results sh...
关键词：prion diseases misfolded prion protein imaging mass spectrometry PEPTIDES biological markers mass spectrometry 
Weak cation exchange 2 protein chip for detecting differentially expressed brainstem proteins in a rat model of closed traumatic brain injury
《Neural Regeneration Research》2010年第5期372-377,共6页Lin Liang Haiying Gong Li Zhan Shuwang Yang Yongliang Zhang 
the National Natural Science Foundation of China, No.30471934
BACKGROUND： Studies have reported the combined use of two-dimensional gel electrophoresis and mass spectrometry to detect differentially expressed proteins in the rat brainstem following brain injury. However, the de...
关键词：protein chip ion exchange brain injury BRAINSTEM rats PROTEOMICS neural regeneration 
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