supported by grants from the Swiss National Science Foundation(310030-182332 and 310030L-208141)(to JP)。
The challenge of protecting the brain resides in the unique characteristics of neurons,as they are postmitotic,long-lived,excitable,and polarized cells with long and fragile axons and dendrites.The complexity of the m...
supported by Fundação de AmparoàPesquisa do Estado do Rio de Janeiro(FAPERJ,E-26/010.002160/2019,E-26/203.227/2017,E-260003/001177/2020,and E-26/201.279/2021);Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq,313757/2020-8,311188/2023-0)(to PMPC).
Neonatal hypoxic-ischemic encephalopathy(HIE)is a significant cause of disability in children.Improving brain function and accelerating neurological recovery may require a combination of neuroprotective and pro-regene...
supported by the National Natural Science Foundation of China,Nos.81871024 (to HN),82301957 (to XW),82001382 (to LL),62127810 (to HN);the Natural Science Foundation of Jiangsu Province of China,No.SBK2020040785 (to LL)。
Neonatal hypoxic-ischemic brain injury is the main cause of hypoxic-ischemic encephalopathy and cerebral palsy.Currently,there are few effective clinical treatments for neonatal hypoxic-ischemic brain injury.Here,we i...
This work was supported by Health Research Council of New Zealand(grants 17/601 and 22/559);the Auckland Medical Research Foundation,the Lottery Health Grants Board of New Zealand,the C.J.Martin Postdoctoral Fellowship and project grant from the National Health and Medical Research Council of Australia(APP1090890 and APP1164954);the Victorian Government’s Operational Infrastructure Support Program(to RG).
Mitigating preterm encephalopathy continues to be one of the greatest challenges in perinatal medicine.Preterm encephalopathy is associated with high mortality,serious morbidity,and significant socio-economic impacts ...
supported by the National Natural Science Foundation of China,Nos.82271327(to ZW),82072535(to ZW),81873768(to ZW),and 82001253(to TL).
We previously showed that hydrogen sulfide(H2S)has a neuroprotective effect in the context of hypoxic ischemic brain injury in neonatal mice.However,the precise mechanism underlying the role of H2S in this situation r...
supported by the National Natural Science Foundation of China,No.82271747(to ZLL);Medical and Health Science and Technology Program of Zhejiang Province of China,No.2023RC048(to WL)。
Hypoxic-ischemic encephalopathy,which predisposes to neonatal death and neurological sequelae,has a high morbidity,but there is still a lack of effective prevention and treatment in clinical practice.To better underst...
supported by the National Natural Science Foundation of China,Nos.81871408 and 81271631(to XMW);National Science Foundation for Young Scientists of China,No.81801658(to YZ);Outstanding Scientific Fund of Shengjing Hospital,No.201402(to XMW);345 Talent Support Project of Shengjing Hospital,No.30B(to YZ)。
Maintaining glutamate homeostasis after hypoxic ischemia is important for synaptic function and neural cell activity,and regulation of glutamate transport between astrocyte and neuron is one of the important modalitie...
supported by the Health Research Council of New Zealand (No.1 7/601 to JD);the Marsden Fund (No.17-UOA232 to JD)
Hypoxic-ischemic encephalopathy(HIE)has an incidence of 1-3 in 1000 term births in high-income countries(Zhou et al.,2020).The standard treatment for these infants is therapeutic hypothermia.Although therapeutic hypot...
supported by the National Natural Science Foundation of China,No.81971425;the Natural Science Foundation of Zhejiang Province,No.LY20H040002(both to XQF).
Recent studies have shown that chlorogenic acid(CGA),which is present in coffee,has protective effects on the nervous system.However,its role in neonatal hypoxic-ischemic brain injury remains unclear.In this study,we ...
support by the Faculty of Medicine,Ludwig-Maximilians-University(FöFoLe,Project 843 and 955,to TH and MMS).
Recent results emphasize the supportive effects of adipose-derived multipotent stem/progenitor cells(ADSPCs)in peripheral nerve recovery.Cultivation under hypoxia is considered to enhance the release of the regenerati...