HYPOXIC

作品数:309被引量:946H指数:15
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相关领域:医药卫生更多>>
相关作者:谭双香戴爱国胡瑞成丁艳洁蒋犁更多>>
相关机构:南华大学首都医科大学北京大学第一医院中国医科大学更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划中国博士后科学基金北京市自然科学基金更多>>
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  • 期刊=Neural Regeneration Researchx
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Neuronal autosis:the self-destructive side of autophagy involved in hypoxic-ischemic neuronal death
《Neural Regeneration Research》2025年第12期3517-3518,共2页Vanessa Ginet Pauline Depierre Julien Puyal 
supported by grants from the Swiss National Science Foundation(310030-182332 and 310030L-208141)(to JP)。
The challenge of protecting the brain resides in the unique characteristics of neurons,as they are postmitotic,long-lived,excitable,and polarized cells with long and fragile axons and dendrites.The complexity of the m...
关键词:DEATH HYPOXIC polarized 
Brain scarring in infants:immunological insights from a neonatal hypoxic-ischemic encephalopathy model
《Neural Regeneration Research》2025年第10期2909-2910,共2页Pedro Moreno Pimentel-Coelho 
supported by Fundação de AmparoàPesquisa do Estado do Rio de Janeiro(FAPERJ,E-26/010.002160/2019,E-26/203.227/2017,E-260003/001177/2020,and E-26/201.279/2021);Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq,313757/2020-8,311188/2023-0)(to PMPC).
Neonatal hypoxic-ischemic encephalopathy(HIE)is a significant cause of disability in children.Improving brain function and accelerating neurological recovery may require a combination of neuroprotective and pro-regene...
关键词:NEONATAL protective HYPOXIC 
Nicotinamide adenine dinucleotide treatment confers resistance to neonatal ischemia and hypoxia:effects on neurobehavioral phenotypes
《Neural Regeneration Research》2024年第12期2760-2772,共13页Xiaowen Xu Xinxin Wang Li Zhang Yiming Jin Lili Li Meifang Jin Lianyong Li Hong Ni 
supported by the National Natural Science Foundation of China,Nos.81871024 (to HN),82301957 (to XW),82001382 (to LL),62127810 (to HN);the Natural Science Foundation of Jiangsu Province of China,No.SBK2020040785 (to LL)。
Neonatal hypoxic-ischemic brain injury is the main cause of hypoxic-ischemic encephalopathy and cerebral palsy.Currently,there are few effective clinical treatments for neonatal hypoxic-ischemic brain injury.Here,we i...
关键词:brain injury cerebral palsy HYPOXIA hypoxic-ischemic brain injury inflammation NEUROPROTECTION nicotinamide adenine dinucleotide NEONATE nicotinamide adenine dinucleotide PROTEOMICS 
Does MgSO_(4) protect the preterm brain?Dissecting its role in the pathophysiology of hypoxic ischemic encephalopathy
《Neural Regeneration Research》2024年第9期1861-1862,共2页Robert Galinsky Laura Bennet Alistair J.Gunn 
This work was supported by Health Research Council of New Zealand(grants 17/601 and 22/559);the Auckland Medical Research Foundation,the Lottery Health Grants Board of New Zealand,the C.J.Martin Postdoctoral Fellowship and project grant from the National Health and Medical Research Council of Australia(APP1090890 and APP1164954);the Victorian Government’s Operational Infrastructure Support Program(to RG).
Mitigating preterm encephalopathy continues to be one of the greatest challenges in perinatal medicine.Preterm encephalopathy is associated with high mortality,serious morbidity,and significant socio-economic impacts ...
关键词:ENCEPHALOPATHY mortality HYPOXIC 
The miR-9-5p/CXCL11 pathway is a key target of hydrogen sulfide-mediated inhibition of neuroinflammation in hypoxic ischemic brain injury被引量:2
《Neural Regeneration Research》2024年第5期1084-1091,共8页Yijing Zhao Tong Li Zige Jiang Chengcheng Gai Shuwen Yu Danqing Xin Tingting Li Dexiang Liu Zhen Wang 
supported by the National Natural Science Foundation of China,Nos.82271327(to ZW),82072535(to ZW),81873768(to ZW),and 82001253(to TL).
We previously showed that hydrogen sulfide(H2S)has a neuroprotective effect in the context of hypoxic ischemic brain injury in neonatal mice.However,the precise mechanism underlying the role of H2S in this situation r...
关键词:chemokine(C-X-C motif)ligand 11 cystathionineβsynthase H2S hypoxic ischemic brain injury inflammation L-CYSTEINE lipopolysaccharide microglia miR-9-5p neuroprotection 
Reperfusion after hypoxia-ischemia exacerbates brain injury with compensatory activation of the antiferroptosis system:based on a novel rat model被引量:3
《Neural Regeneration Research》2023年第10期2229-2236,共8页Tian-Lei Zhang Zhi-Wei Zhang Wei Lin Xin-Ru Lin Ke-Xin Lin Ming-Chu Fang Jiang-Hu Zhu Xiao-Ling Guo Zhen-Lang Lin 
supported by the National Natural Science Foundation of China,No.82271747(to ZLL);Medical and Health Science and Technology Program of Zhejiang Province of China,No.2023RC048(to WL)。
Hypoxic-ischemic encephalopathy,which predisposes to neonatal death and neurological sequelae,has a high morbidity,but there is still a lack of effective prevention and treatment in clinical practice.To better underst...
关键词:ferroptosis hypoxic-ischemic brain injury hypoxic-ischemic encephalopathy hypoxic-ischemic reperfusion brain injury mitochondria model proteomic analysis REPERFUSION Rice-Vannucci transmission electron microscopy 
Astrocyte-neuron communication mediated by the Notch signaling pathway:focusing on glutamate transport and synaptic plasticity被引量:8
《Neural Regeneration Research》2023年第10期2285-2290,共6页Ke-Xin Li Meng Lu Meng-Xu Cui Xiao-Ming Wang Yang Zheng 
supported by the National Natural Science Foundation of China,Nos.81871408 and 81271631(to XMW);National Science Foundation for Young Scientists of China,No.81801658(to YZ);Outstanding Scientific Fund of Shengjing Hospital,No.201402(to XMW);345 Talent Support Project of Shengjing Hospital,No.30B(to YZ)。
Maintaining glutamate homeostasis after hypoxic ischemia is important for synaptic function and neural cell activity,and regulation of glutamate transport between astrocyte and neuron is one of the important modalitie...
关键词:ASTROCYTE astrocyte-neuron communication glutamate glutamate transporter hypoxic-ischemic injury magnetic resonance spectroscopy NEONATE Notch signaling pathway plasticity SYNAPSE 
Targeting neuroinflammation after therapeutic hypothermia for perinatal hypoxic-ischemic brain injury
《Neural Regeneration Research》2023年第6期1261-1262,共2页Kelly Q.Zhou Joanne O.Davidson 
supported by the Health Research Council of New Zealand (No.1 7/601 to JD);the Marsden Fund (No.17-UOA232 to JD)
Hypoxic-ischemic encephalopathy(HIE)has an incidence of 1-3 in 1000 term births in high-income countries(Zhou et al.,2020).The standard treatment for these infants is therapeutic hypothermia.Although therapeutic hypot...
关键词:THERAPEUTIC INFLAMMATION protective 
Chlorogenic acid alleviates hypoxic-ischemic brain injury in neonatal mice被引量:7
《Neural Regeneration Research》2023年第3期568-576,共9页Lu-Yao Li Qi Wang Lu Deng Zhen Lin Jing-Jing Lin Xin-Ye Wang Tian-Yang Shen Yi-Hui Zheng Wei Lin Pei-Jun Li Xiao-Qin Fu Zhen-Lang Lin 
supported by the National Natural Science Foundation of China,No.81971425;the Natural Science Foundation of Zhejiang Province,No.LY20H040002(both to XQF).
Recent studies have shown that chlorogenic acid(CGA),which is present in coffee,has protective effects on the nervous system.However,its role in neonatal hypoxic-ischemic brain injury remains unclear.In this study,we ...
关键词:chlorogenic acid ferroptosis glutathione peroxidase 4 lipid peroxidation neonatal hypoxic-ischemic brain injury NEURONS NEUROPROTECTION oxidative stress oxygen-glucose deprivation system Xc^(-) 
Hypoxic pre-conditioned adipose-derived stem/progenitor cells embedded in fibrin conduits promote peripheral nerve regeneration in a sciatic nerve graft model
《Neural Regeneration Research》2023年第3期652-656,共5页Julius M.Mayer Christian Krug Maximilian M.Saller Annette Feuchtinger Riccardo E.Giunta Elias Volkmer Thomas Holzbach 
support by the Faculty of Medicine,Ludwig-Maximilians-University(FöFoLe,Project 843 and 955,to TH and MMS).
Recent results emphasize the supportive effects of adipose-derived multipotent stem/progenitor cells(ADSPCs)in peripheral nerve recovery.Cultivation under hypoxia is considered to enhance the release of the regenerati...
关键词:adipose-derived progenitor cells adipose-derived multipotent stem/progenitor cell autologous nerve graft fibrin conduit hypoxia hypoxic pre-conditioning nerve defect nerve tissue engineering peripheral nerve regeneration regenerative medicine 
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