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检索条件："关键词=Alzheimer’s "
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Detection of Alzheimer’s disease onset using MRI and PET neuroimaging:longitudinal data analysis and machine learning被引量：4
《Neural Regeneration Research》2023年第10期2134-2140,共7页Iroshan Aberathne Don Kulasiri Sandhya Samarasinghe 
The scientists are dedicated to studying the detection of Alzheimer’s disease onset to find a cure, or at the very least, medication that can slow the progression of the disease. This article explores the effectivene...
关键词：deep learning image processing linear mixed effect model NEUROIMAGING neuroimaging data sources onset of Alzheimer’s disease detection pattern recognition 
Long-term radiofrequency electromagnetic fields exposure attenuates cognitive dysfunction in 5×FAD mice by regulating microglial function
《Neural Regeneration Research》2023年第11期2497-2503,共7页Yeonghoon Son Hye-Jin Park Ye Ji Jeong Hyung-Do Choi Nam Kim Hae-June Lee 
Institute of Information&Communications Technology Planning&Evaluation(IITP)grant funded by Korea government(MSIT),Nos.2017-0-00961 and 2019-0-00102(to HDC)。
We have previously found that long-term effects of exposure to radiofrequency electromagnetic fields in 5xFAD mice with severe late-stage Alzheimer’s disease reduced both amyloid-βdeposition and glial activation,inc...
关键词：5×FAD Alzheimer’s disease CSF1R long term exposure microglial function NEUROINFLAMMATION radiofrequency electromagnetic fields therapeutic effect 
Polyoxidovanadates a new therapeutic alternative for neurodegenerative and aging diseases被引量：1
《Neural Regeneration Research》2024年第3期571-577,共7页Sonia Irais Gonzalez-Cano Gonzalo Flores Jorge Guevara Julio Cesar Morales-Medina Samuel Treviño Alfonso Diaz 
funded by project from National Research System (CONACYT),Mexico (to SIGC)
Aging is a natural phenomenon characterized by a progressive decline in physiological integrity,leading to a deterioration of cognitive function and increasing the risk of suffering from chronic-degenerative diseases,...
关键词：Alzheimer’s disease ANTIDIABETIC brain cognition diabetes insulin NEURODEGENERATION NEUROINFLAMMATION oxidative stress Vanadium species 
Tau in neurodegenerative diseases:molecular mechanisms,biomarkers,and therapeutic strategies
《Translational Neurodegeneration》2024年第1期513-529,共17页Xingyu Zhang Jiangyu Wang Zhentao Zhang Keqiang Ye 
supported by grants from the National Key Basic Research Program of China(2019YFE0115900 to Z.Z.);the National Natural Science Foundation of China(81822016,81771382 to Z.Z.,82301356 to X.Z.,32330040,82350710222 to K.Y.).
The deposition of abnormal tau protein is characteristic of Alzheimer’s disease(AD)and a class of neurodegenerative diseases called tauopathies.Physiologically,tau maintains an intrinsically disordered structure and ...
关键词：TAU Alzheimer’s disease TAUOPATHIES AGGREGATION PROPAGATION Biomarkers 
Studying Alzheimer’s Disease Using Drosophila melanogaster as a Powerful Tool
《Advances in Alzheimer's Disease》2022年第3期23-37,共15页Jacob Kasanin Xingjun Wang Wanting Jiao Qiuyu Li Bingwei Lu 
Background: Alzheimer’s disease (AD) is an increasingly prevalent neurodegenerative disease characterized by protein aggregation in the form of amyloid plaques containing beta-amyloid peptides and neurofibrillary tan...
关键词：DROSOPHILA Alzheimer’s Disease APP C99 AΒ42 TAU 
Advances in Early Prevention of Alzheimer’s Disease in the Aged
《Yangtze Medicine》2020年第1期1-10,共10页Liu Zhang Yanlin Heng Gaijing Wang 
Alzheimer’s disease (AD) is a progressive neurodegenerative disease, is one of the leading causes of death in the aging population, and has become a serious public problem endangering the physical and mental health o...
关键词：Aged EARLY PREVENTION Alzheimer’s DISEASE 
Structural Features of Human Memapsin 2 (β-Secretase) and Their Biological and Pathological Implications被引量：1
《Acta Biochimica et Biophysica Sinica》2004年第12期787-792,共6页Jordan TANG 
This work was supported by a grant from NIH (No. AG-18933) and an Alzheimer’s Association Pioneer Award to Prof. Jordan TANG
Memapsin 2 (β-secretase) is the membrane-anchored aspartic protease that initiates the cleavage of β-amyloid precursor protein (APP) leading to the production of amyloid-β (Aβ), a major factor in the patho...
关键词：memapsin 2 Β-SECRETASE Alzheimer’s disease Β-AMYLOID β-amyloid precursor protein aspartic protease ENDOCYTOSIS cellular trafficking. 
A pancreatic player in dementia:pathological role for islet amyloid polypeptide accumulation in the brain
《Neural Regeneration Research》2023年第10期2141-2146,共6页Angelina S.Bortoletto Ronald J.Parchem 
supported by The Mike Hogg Fund;Baylor College of Medicine Medical Scientist Training Program,NICHD R01HD099252(to RJP)and R01HD098131(to RJP);the NHLBI T32 HL092332(to ASB)。
Type 2 diabetes mellitus patients have a markedly higher risk of developing dementia.While multiple factors contribute to this predisposition,one of these involves the increased secretion of amylin,or islet amyloid po...
关键词：Alzheimer’s disease AMYLIN AMYLOID DEMENTIA diabetes human islet amyloid polypeptide islet amyloid polypeptide PROTOFIBRILS type 2 diabetes mellitus vascular dementia 
Retinal thickness and vascular parameters using optical coherence tomography in Alzheimer's disease:a meta-analysis
《Neural Regeneration Research》2023年第11期2504-2513,共10页Samran Sheriff Ting Shen Sandra Abdal Danit Saks Mehdi Mirzaei Veer Gupta Nitin Chitranshi Yuyi You Angela Schultz Stuart L.Graham Vivek Gupta 
National Health and Medical Research Council (NHMRC) Australia (to VG)。
Examining the retinal tissue has the potential to provide a unique method and technique to quantify Alzheimer’s disease-related changes in participants at various stages of the disease.In this metaanalysis,we aimed t...
关键词：Alzheimer’s disease foveal avascular zone macular thickness optical coherence tomography optical coherence tomography angiography RETINA retinal nerve fiber layer vessel density 
Neuronal double-stranded DNA accumulation induced by DNase II deficiency drives tau phosphorylation and neurodegeneration
《Translational Neurodegeneration》2024年第1期530-546,共17页Ling-Jie Li Xiao-Ying Sun Ya-Ru Huang Shuai Lu Yu-Ming Xu Jing Yang Xi-Xiu Xie Jie Zhu Xiao-Yun Niu Dan Wang Shi-Yu Liang Xiao-Yu Du Sheng-Jie Hou Xiao-Lin Yu Rui-Tian Liu 
supported by funding from the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB39050600);the National Natural Science Foundation of China(82150107 and 81971073);the National Key Research and Development Program of China(2020YFA0712402).
Background Deoxyribonuclease 2(DNaseⅡ)plays a key role in clearing cytoplasmic double-stranded DNA(dsDNA).Deficiency of DNaseⅡleads to DNA accumulation in the cytoplasm.Persistent dsDNA in neurons is an early pathol...
关键词：DNaseⅡ Alzheimer’s disease Double-stranded DNA Tau phosphorylation TAUOPATHY 
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