Ministry of Science and Technology of the People’s Republic of China(2018YFA0800103,2018YFA0801004);National Natural Science Foundation of China(NSFC31530044,NSFC31970780,NSFC82202056).
Generation of induced renal epithelial cells(iRECs)from fibroblasts offers great opportunities for renal disease mod-eling and kidney regeneration.However,the low reprogramming efficiency of the current approach to ge...
This review article focuses on low back pain(LBP)caused by intervertebral disc(IVD)degeneration and the need to better understand the mechanisms involved.The specific roles of cellular populations and molecular pathwa...
National Natural Science Foundation of China(82372663);Key Research and Development Program of Jiangxi Province(20232BBG70024);Key Research and Development Program of Yunnan Province(202302AA310024);Natural Science Foundation of Shandong Province(ZR2023LSW008)and the Faculty Resources Project of College of Life Sciences(Inner Mongolia University 2022−103).
Tissue stem cells(TSCs),which reside in specialized tissues,constitute the major cell sources for tissue homeosta-sis and regeneration,and the contribution of transcriptional or epigenetic regulation of distinct biolo...
National Natural Science Foundation of China(32270574,92068201);Science and Technology Projects in Guangzhou(2023A03J0045);Guangzhou Key Laboratory of Biological Targeting Diagnosis and Therapy(202201020379);Key Laboratory of Guangdong Higher Education Institutes(2021KSYS009).
Endogenous retroviruses(ERVs),once thought to be mere remnants of ancient viral integrations in the mammalian genome,are now recognized for their critical roles in various physiological processes,including embryonic d...
National Key R&D Program of China(No.2022YFA1104700)to Zhang X;National Natural Science Foundation of China(No.32171406)to Qin J;Innovation Program of Science and Research from the DICP,CAS(DICP I202435)to Qin J.
Organs-on-chips are microphysiological systems that allow to replicate the key functions of human organs and accel-erate the innovation in life sciences including disease modeling,drug development,and precision medici...
The author has retracted this article because they did not have permission to publish the material contained therein.This has been confirmed by an investigation by i3S-Institute for Research and Innovation in Health o...
National Natural Science Foundation of China(31988101 to YGC,92354306 to YL);National Key Research and Development Program of China(2023YFA1800603);Natural Science Foundation of Jiangxi Province(20224ACB209001);Beijing Science and Technology Plan(Z231100007223006);Shenzhen Medical Research Fund(B2302022)to YGC.
Intestinal epithelial cells(IECs)are pivotal for maintaining intestinal homeostasis through self-renewal,proliferation,differentiation,and regulated cell death.While apoptosis and necroptosis are recognized as distinc...
National Natural Science Foundation of China(82371627);Open Research Fund of Key Laboratory of Reproductive Medicine of Guangdong Province(2020B121206002902);Natural Science Foundation of Fujian Province(2021J011346);Xiamen Medical and Health Guidance Project(3502Z20244ZD1021).
F-box proteins play essential roles in various cellular processes of spermatogenesis by means of ubiquitylation and subsequent target protein degradation.They are the substrate-recognition subunits of SKP1–cullin 1–...
National Key R&D Program of China(2023YFA1800100);Shenzhen Medical Research Fund(B2302034);Major Program of Shenzhen Bay Laboratory(S201101002).
Macrophages play crucial and versatile roles in regulating tissue repair and regeneration upon injury.However,due to their complex compositional heterogeneity and functional plasticity,deciphering the nature of differ...
National Key Research and Development Program of China(2022YFC3401502 to X-H.F.,2023YFA1800603 to Y-G.C.);National Natural Science Foundation of China(U21A20356 and 32321002 to X-H.F.,31988101 to Y-G.C.);Zhejiang Provincial Natural Science Foundation(LD21C070001 to X-H.F.,LZ22C070001 to S.G.);Fundamental Research Funds for the Central Universities。
The family of secreted dimeric proteins known as the Transforming Growth Factor-β(TGF-β)family plays a critical role in facilitating intercellular communication within multicellular animals.A recent symposium on TGF...