HOMEOSTASIS

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GnIH secreted by green light exposure,regulates bone mass through the activation of Gpr147
《Bone Research》2025年第1期212-223,共12页Yu You Konglin Huo Liang He Tongyue Wang Lei Zhao Rong Li Xiaoqing Cheng Xuebin Ma Zhiying Yue Stefan Siwko Ning Wang Lujian Liao Mingyao Liu Jian Luo 
National Key Research and Development Program of China(2023YFB3810200 to J.L.);National Natural Science Foundation of China(92168204,82225030 to J.L.);Fundamental Research Funds for the Central Universities(22120210586 to J.L.)。
Reproductive hormones associated with the hypothalamic-pituitary-gonadal(HPG)axis are closely linked to bone homeostasis.In this study,we demonstrate that Gonadotropin inhibitory hormone(GnIH,one of the key reproducti...
关键词：ACTIVATION HOMEOSTASIS GNIH 
Skeletal interoception and prospective application in biomaterials for bone regeneration
《Bone Research》2025年第1期1-14,共14页Long Bai Jilong Li Guangfeng Li Dongyang Zhou Jiacan Su Changsheng Liu 
National Natural Science Foundation of China(82230071,82172098);Integrated Project of Major Research Plan of National Natural Science Foundation of China(92249303);Shanghai Committee of Science and Technology(23141900600,Laboratory Animal Research Project);Shanghai Clinical Research Plan of SHDC2023CRT01;Young Elite Scientist Sponsorship Program by China Association for Science and Technology(YESS20230049)。
Accumulating research has shed light on the significance of skeletal interoception,in maintaining physiological and metabolic homeostasis related to bone health.This review provides a comprehensive analysis of how ske...
关键词：HOMEOSTASIS BIOMATERIALS utilize 
PCLAF induces bone marrow adipocyte senescence and contributes to skeletal aging被引量：1
《Bone Research》2024年第3期595-610,共16页Lingqi Xie Yalun Cheng Biao Hu Xin Chen Yuze An Zhuying Xia Guangping Cai Changjun Li Hui Peng 
supported by the National Key R&D Program of China (2021YFC2501702);the National Natural Science Foundation of China,China (grant nos.82270911,82201746,82000848,82300998);the National Key Research and Development Plan (2022YFC3601900,2022YFC3601901,2022YFC3601902,2022YFC3601903,2022YFC3601904,and 2022YFC3601905);the Key Research and Development Program of Hunan Province,China (2022WK2010)。
Bone marrow adipocytes(BMAds)affect bone homeostasis,but the mechanism remains unclear.Here,we showed that exercise inhibited PCNA clamp-associated factor(PCLAF)secretion from the bone marrow macrophages to inhibit BM...
关键词：SKELETAL inhibited HOMEOSTASIS 
Induction of osteoblast apoptosis stimulates macrophage efferocytosis and paradoxical bone formation
《Bone Research》2024年第3期634-647,共14页Lena Batoon Amy Jean Koh Susan Marie Millard Jobanpreet Grewal Fang Ming Choo Rahasudha Kannan Aysia Kinnaird Megan Avey Tatyana Teslya Allison Robyn Pettit Laurie K.McCauley Hernan Roca 
supported in part by funding from the National Institutes of Health (DK053904,DE022327,AR077539,CA093900,CA046592 and P30 AR069620);National Health and Medical Research Council (APP1143802);Mater Foundation.
Apoptosis is crucial for tissue homeostasis and organ development.In bone,apoptosis is recognized to be a main fate of osteoblasts,yet the relevance of this process remains underexplored.Using our murine model with in...
关键词：development HOMEOSTASIS BONE 
Coactivator-independent vitamin D receptor signaling causes severe rickets in mice,that is not prevented by a diet high in calcium,phosphate,and lactose
《Bone Research》2024年第3期648-660,共13页Stefanie Doms Lieve Verlinden Iris Janssens Justine Vanhevel Roy Eerlings RenéHoutman Shigeaki Kato Chantal Mathieu Brigitte Decallonne Geert Carmeliet Annemieke Verstuyf 
the University of Leuven (C16/18/006);the Flanders Research Foundation (FWO;G0D0120N,G0D4217N and G081723N)。
The vitamin D receptor(VDR)plays a critical role in the regulation of mineral and bone homeostasis.Upon binding of 1α,25-dihydroxyvitamin D_(3) to the VDR,the activation function 2(AF2)domain repositions and recruits...
关键词：VITAMIN HOMEOSTASIS POSITIONS 
Wnt/β-catenin signaling components and mechanisms in bone formation,homeostasis,and disease被引量：3
《Bone Research》2024年第3期469-501,共33页Lifang Hu Wei Chen Airong Qian Yi-Ping Li 
supported by the National Natural Science Foundation of China (81772017 to[L.F.H.],and 82072106 and 32371371 to[A.R.Q.]);The Project Supported by Natural Science Basic Research Plan in Shaanxi Province of China (2023-JC-YB-163 to[L.F.H.]);the National Institutes of Health[AR-070135 and AG-056438 to W.C.,and AR075735,DE023813,AR074954,and DE028264 to Y.P.L.]。
Wnts are secreted,lipid-modified proteins that bind to different receptors on the cell surface to activate canonical or non-canonical Wnt signaling pathways,which control various biological processes throughout embryo...
关键词：HOMEOSTASIS CANONICAL MECHANISMS 
Skeletal interoception in osteoarthritis
《Bone Research》2024年第2期241-254,共14页Dinglong Yang Jiawen Xu Ke Xu Peng Xu 
supported by the National Natural Science Foundation of China(82072432).
The interoception maintains proper physiological conditions and metabolic homeostasis by releasing regulatory signals after perceving changes in the internal state of the organism.Among its various forms,skeletal inte...
关键词：HOMEOSTASIS INFLAMMATION RELEASING 
The role and applications of extracellular vesicles in osteoporosis被引量：3
《Bone Research》2024年第1期62-77,共16页Fei Fang Jie Yang Jiahe Wang Tiantian Li Erxiang Wang Demao Zhang Xiaoheng Liu Chenchen Zhou 
This study was supported by the National Natural Science Foundation of China(Grant numbers 11932014,12372315 and 32301089);the Sichuan Science and Technology Program(Grant numbers 2022NSFSC0765 and 2022ZYD0079).
Osteoporosis is a widely observed condition characterized by the systemic deterioration of bone mass and microarchitecture,which increases patient susceptibility to fragile fractures.The intricate mechanisms governing...
关键词：OSTEOPOROSIS HOMEOSTASIS BIOMATERIALS 
Osteomodulin downregulation is associated with osteoarthritis development被引量：1
《Bone Research》2023年第4期721-736,共16页Jérémie Zappia Qiao Tong Renée Van der Cruyssen Frederique MFCornelis Cécile Lambert Tiago Pinto Coelho Juliane Grisart Erika Kague Rik JLories Marc Muller Dirk Elewaut Chrissy LHammond Christelle Sanchez Yves Henrotin 
funded by the F.R.S.-FNRS for the “EOS: The Excellence of Science-Join-t-against-Osteoarthritis”, grant number 30480119;by a research grant from the Osteoarthritis Foundation and by the University of Liege (Fonds Léon Fredericq and Fonds Speciaux à la Recherche);funded by Versus Arthritis senior fellowship 21937。
Abnormal subchondral bone remodeling leading to sclerosis is a main feature of osteoarthritis(OA), and osteomodulin(OMD), a proteoglycan involved in extracellular matrix mineralization, is associated with the scleroti...
关键词：METABOLISM CONCLUSION HOMEOSTASIS 
Interoceptive regulation of skeletal tissue homeostasis and repair被引量：4
《Bone Research》2023年第3期481-496,共16页Yao Xiao Changhao Han Yunhao Wang Xinshu Zhang Rong Bao Yuange Li Huajiang Chen Bo Hu Shen Liu 
supported by the National Natural Science Foundation of China (No.82172408,81902234,81772314,and 81922045);the Original Exploration project (22ZR1480300);Outstanding Academic Leaders (Youth)project (21XD1422900)of Shanghai Science and Technology Innovation Action Plan;Principle Investigator Innovation Team of Both Shanghai Sixth People’s Hospital and Shanghai Institute of Nutrition and Health,Shanghai Jiao Tong University Medical College“Two-hundred Talent”Program (No.20191829);The Second Three-Year Action Plan for Promoting Clinical Skills and Clinical Innovation in Municipal Hospitals of Shanghai Shenkang (No.SHDC2020CR4032);Shanghai Excellent Academic Leader Program;Shanghai Engineering Research Center for Orthopaedic Material Innovation and Tissue Regeneration (No.20DZ2254100)。
Recent studies have determined that the nervous system can sense and respond to signals from skeletal tissue,a process known as skeletal interoception,which is crucial for maintaining bone homeostasis.The hypothalamus...
关键词：SYSTEM HOMEOSTASIS MAINTAIN 
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