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SYNAPTIC: 作品数：321被引量：722H指数：13; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：于洋余剑平赵志奇熊志奇杨柳更多>>; 相关机构：中国科学院加拿大多伦多大学第四军医大学滨州医学院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家教育部博士点基金更多>>

Neural circuit mechanisms of epilepsy:Maintenance of homeostasis at the cellular,synaptic,and neurotransmitter levels: 《Neural Regeneration Research》2026年第2期455-465,共11页Xueqing Du Yi Wang Xuefeng Wang Xin Tian Wei Jing; supported by Basic Research Programs of Science and Technology Commission Foundation of Shanxi Province,No.20210302123486(to WJ).; Epilepsy,a common neurological disorder,is characterized by recurrent seizures that can lead to cognitive,psychological,and neurobiological consequences.The pathogenesis of epilepsy involves neuronal dysfunction at th...; 关键词：chemical genetics hippocampus literature review neural circuits NEUROTRANSMITTER OPTOGENETICS pathogenesis SEIZURE synapses THALAMUS

Small molecule inhibitor DDQ-treated hippocampal neuronal cells show improved neurite outgrowth and synaptic branching: 《Neural Regeneration Research》2025年第9期2624-2632,共9页Jangampalli Adi Pradeepkiran Priyanka Rawat Arubala P.Reddy Erika Orlov PHemachandra Reddy; supported by NIH grants AG079264(to PHR)and AG071560(to APR)。; The process of neurite outgrowth and branching is a crucial aspect of neuronal development and regeneration.Axons and dendrites,sometimes referred to as neurites,are extensions of a neuron's cellular body that are use...; 关键词：diethyl(3 4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ) hippocampal neuronal cells HT22 neurite outgrowth neuronal development small molecule

The role of axon guidance molecules in the pathogenesis of epilepsy: 《Neural Regeneration Research》2025年第5期1244-1257,共14页Zheng Liu Chunhua Pan Hao Huang; supported by the National Natural Science Foundation of China,Nos. 81760247, 82171450;the Scientific Research Foundation for Doctors of the Affiliated Hospital of Zunyi Medical University,No.(2016)14 (all to HH)。; Current treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progression of the disease. Consequently, it is crucial to identify drugs that can target no...; 关键词：axon guidance drug-resistant epilepsy EPILEPSY nerve regeneration nervous system diseases neural pathways neuroinflammatory diseases neuronal plasticity NEURONS synaptic remodeling

Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly: 《Neural Regeneration Research》2025年第5期1409-1410,共2页Rafael Lujan Alejandro Martín-Belmonte Sergi Ferré Francisco Ciruela; Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic plasticity.AD has progressively been recognized as syna ptopathy and ...; 关键词：ALZHEIMER PATHOLOGY

Heat acclimation in mice requires preoptic BDNF neurons and postsynaptic potentiation: 《Cell Research》2025年第3期224-227,共4页Baoting Chen Cuicui Gao Changhao Liu Tongtong Guo Junwei Hu Jialiang Xue Kangmin Tang Yuelai Chen Tian Yu Qiwei Shen Hongbin Sun Wen Z.Yang Wei L.Shen; funded by the National Natural Science Foundation of China(92357304,32330042,and 32425028 to W.L.S.;32471076,32100825 to W.Z.Y.;32471205 to H.S.);Shanghai Sailing Program(21YF1429800 to W.Z.Y.);Shanghai Science and Technology Committee of Shanghai City(24ZR1451700 to H.S.);Shanghai Frontiers Science Center for Biomacromolecules and Precision Medicine at Shanghai Tech University。; Dear Editor,Heat acclimation(HA)is a key adaptive response in mammals to repeated heat exposure,essential for fitness and survival.1,2 HA improves cardiovascular function,thermal comfort,and exercise capacity.3,4 Howe...; 关键词：genetically tractable model brain derived neurotrophic factor medial preoptic area dorsomedial hypothalamus heat acclimation synaptic potentiation rostral raphe pallidus tropomyosin related kinase b

Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation: 《Neural Regeneration Research》2025年第2期326-342,共17页Yi Ji Chaoyi Yang Xuerui Pang Yibing Yan Yue Wu Zhi Geng Wenjie Hu Panpan Hu Xingqi Wu Kai Wang; supported by the Hefei Comprehensive National Science Center Hefei Brain Project(to KW);the National Natural Science Foundation of China,Nos.31970979(to KW),82101498(to XW);the STI2030-Major Projects,No.2021ZD0201800(to PH).; Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and homeostasis.The Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neur...; 关键词：Alzheimer’s disease amyloid deposition apoptotic mechanisms BIOMARKER neural regeneration NEURODEGENERATION repetitive transcranial magnetic stimulation synaptic plasticity

Advances in synaptic PET imaging and intervention with synapse-targeted small-molecular drugs for dementia diagnosis and therapy被引量：1: 《Fundamental Research》2025年第1期63-71,共9页Xiuhong Lu Bin Ji Gang Huang Hong Ding; funding support from the National Natural Science Foundation of China(81971016);Shanghai Science and Technology program(21010502300);Construction project of Shanghai Key Laboratory of Molecular Imaging(18DZ2260400).; Dementia is characterized by synaptic and neuronal dysfunction in disease-specific brain regions.Repeated failure of dementia clinical trials with therapeutic drugs targeting abnormal protein aggregates has caused res...; 关键词：Synaptic density imaging Synaptic vesicle protein 2A DEMENTIA Multimodal imaging UCB-J Positron emission tomography

Tofacitinib prevents depressive-like behaviors through decreased hippocampal microgliosis and increased BDNF levels in both LPS-induced and CSDS-induced mice: 《Acta Pharmacologica Sinica》2025年第2期353-365,共13页Ya-nan Gao Kai-jun Pan Yong-mei Zhang Ying-bei Qi Wen-gang Chen Ting Zhou Hai-chao Zong Hao-ran Guo Jin-wen Zhao Xing-chen Liu Zi-tong Cao Ze Chen Tao Yin Yi Zang Jia Li; founded by National Natural Science Foundation of China grant 82001572;National Natural Science Foundation of China grant 81971265;National Science&Technology Major Project“Key New Drug Creation and Manufacturing Program”grant 2018ZX09711002-007-002;Shanghai Commission of Science and Technology grant 2021000003;Shanghai Science and Technology Development Funds(Shanghai Commission of Science and Technology)grant 19JC1416300.; Depressive disorders are a global mental health challenge that is closely linked to inflammation,especially in the post-COVID-19 era.The JAK-STAT pathway,which is primarily associated with inflammatory responses,is no...; 关键词：tofacitinib depression JAK-STAT pathway MICROGLIOSIS synaptic defects

DTD1 modulates synaptic efficacy by maintaining D-serine and D-aspartate homeostasis: 《Science China(Life Sciences)》2025年第2期467-483,共17页Xiao Liu Chaojuan Yang Zhuoran Lin Jianing Li Bin Yin Xuepei Lei Wei Han Boqin Qiang Pengcheng Shu Chen Zhang Xiaozhong Peng; supported by the National Science and Technology Innovation 2030 Grants of China(2021ZD0200902 to Peng,X.);the National Key Research and Development Program of China(2017YFA0105201 to Zhang,C.);the Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(CIFMS;2021-1-I2M-019 to Shu,P.and 2021-1-I2M-024 to Peng,X.);the National Natural Science Foundation of China(31670789 to Peng,X.,32370883 to Shu,P.,81925011 to Zhang,C.,82001145 to Yang,C.);the State Key Laboratory Special Fund 2060204。; D-serine and D-aspartate are involved in N-methyl-D-aspartate receptor(NMDAR)-related physiological and pathological processes.Daminoacyl-t RNA deacylase 1(DTD1)may biochemically contribute to D-serine or D-aspartate ...; 关键词：D-aminoacyl-tRNA deacylase 1 D-SERINE D-ASPARTATE synaptic transmission neuronal morphology spatial learning and memory

Nogo-A Protein Mediates Oxidative Stress and Synaptic Damage Induced by High-Altitude Hypoxia in the Rat Hippocampus: 《Biomedical and Environmental Sciences》2025年第1期79-93,共15页Jinyu Fang Huaicun Liu Yanfei Zhang Quancheng Cheng Ziyuan Wang Xuan Fang Huiru Ding Weiguang Zhang Chunhua Chen; supported by Beijing Natural Science Foundation(No.7232090);the National Natural Science Foundation of China(82101306);the Scientific and Technological Innovation 2030(2021ZD0201100).; Objective High-altitude hypoxia exposure often damages hippocampus-dependent learning and memory.Nogo-A is an important axonal growth inhibitory factor.However,its function in high-altitude hypoxia and its mechanism o...; 关键词：NOGO-A NgR1 High-altitude hypoxia Learning and memory Oxidative stress

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