supported by grants PID2020-120308RB-I00 and PID2023-147802OB-I00 funded by MICIU/AEI/10.13039/501100011033;FEDER,UE,by Aligning Science Across Parkinson’s(ref.ASAP-020505)through the Michael J.Fox Foundation for Parkinson’s Research;by CiberNed Intramural Collaborative Projects(ref.PI2020/09);by the Spanish Fundación Mutua Madrile?a de Investigación Médica(to JLL)。
The development of clinical candidates that modify the natural progression of sporadic Parkinson's disease and related synucleinopathies is a praiseworthy endeavor,but extremely challenging.Therapeutic candidates that...
Dopamine,often termed the"feel-good"neurotransmitter,plays a crucial role in myriad physiological and psychological brain processes.While dopamine is primarily associated with pleasure,reward,and motivation,its effect...
supported by an under-40 grant from the Italian Association for Alzheimer’s Research [AIRALZH AGYR2021];the Strategic University Projects–Young Researcher Independence grant [YRG2021] from the Università Campus Bio-Medico di Roma (Rome, Italy)(to LLB);Italian Ministry of Health [Research Grant:GR-2019-12370446];the American Alzheimer’s Association [AARG-22-922961](to PK)。
Despite decades of dedicated resea rch,Alzheimer's disease (AD) is an age-related and progressive neurodegenerative disorder for which the mechanisms of onset are sti unc ear.AD is cha racterized by featured histologi...
supported by funding from Parkinson Canada;funded by a scholarship from Parkinson Canada;a scholarship from Fonds d’Enseignement et de Recherche (FER) (Faculty of Pharmacy, Université Laval)
There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after diagnosis.Given that preclinical and clinical studies suggest benefits of dietary n-3 poly...
supported by the National Natural Science Foundation of China,No.82101263;Jiangsu Province Science Foundation for Youths,No.BK20210903;Research Foundation for Talented Scholars of Xuzhou Medical University,No.RC20552114(all to CT)。
Parkinson’s disease can affect not only motor functions but also cognitive abilities,leading to cognitive impairment.One common issue in Parkinson’s disease with cognitive dysfunction is the difficulty in executive ...
Parkinson’s disease(PD) is characterized by the slow and progressive demise of dopamine(DA)-synthesizing neurons in the substantia nigra pars compacta(SNc),a nucleus located in the human ventral midbrain.Neuron death...
supported by the STI 2030-Major Projects,No.2021ZD0200500;the Natural Science Foundation of Shanghai,No.21ZR1419700(both to SL)。
Parkinson's disease(PD)is a progressive neurodegenerative disorder with clinical symptoms of involuntary or uncontrollable movements such as tremors,rigidity,and incoordination.The learning deficit is largely overlook...
the Singapore Ministry of Health's National Medical Research Council (Open Fund Large Collaborative Grant (MOH-000207);Singapore Translational Research (STaR) Investigator A word (NMRC/STaR/0030/2018) to EKT,CS-IRG-NIG,OF-YIRG and TA award to BX) for their support。
Parkinson's disease(PD), characterized by the loss of dopaminergic(DA) neurons in the substantia nigra pars compacta(SNpc) of the midbrain, is a prototype neurological disease that is suitable for cellular replacement...
Parkinson’s disease is the most common movement disorder,affecting about 1%of the population over the age of 60 years.Parkinson’s disease is characterized clinically by resting tremor,bradykinesia,rigidity and postu...
supported by the National Natural Science Foundation of China,Nos. 81971006 (to DSG), 82101263 (to CXT);Jiangsu Province Science Foundation for Youths,No. BK20210903 (to CXT);Research Foundation for Talented Scholars of Xuzhou Medical University,No. RC20552114 (to CXT);Science&Technology Program of Xuzhou,No. KC19016 (to JC);Project of Xuzhou Medical University,No. 2018KJ06 (to JC)。
Studies have found that the absence of glial cell line-derived neurotrophic factor may be the primary risk factor for Parkinson’s disease. However, there have not been any studies conducted on the potential relations...