DOPAMINE

作品数:528被引量:879H指数:11
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相关领域:医药卫生更多>>
相关作者:王俊姜宏谢俊霞邱海波杨毅更多>>
相关机构:首都医科大学北京大学中国科学院山东大学更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划中国博士后科学基金北京市自然科学基金更多>>
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  • 期刊=Neural Regeneration Researchx
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Adeno-associated viral vectors for modeling Parkinson's disease in non-human primates
《Neural Regeneration Research》2026年第1期224-232,共9页Julia Chocarro JoséL.Lanciego 
supported by grants PID2020-120308RB-I00 and PID2023-147802OB-I00 funded by MICIU/AEI/10.13039/501100011033;FEDER,UE,by Aligning Science Across Parkinson’s(ref.ASAP-020505)through the Michael J.Fox Foundation for Parkinson’s Research;by CiberNed Intramural Collaborative Projects(ref.PI2020/09);by the Spanish Fundación Mutua Madrile?a de Investigación Médica(to JLL)。
The development of clinical candidates that modify the natural progression of sporadic Parkinson's disease and related synucleinopathies is a praiseworthy endeavor,but extremely challenging.Therapeutic candidates that...
关键词:adeno-associated viral vectors ALPHA-SYNUCLEIN DOPAMINE Lewy bodies NEURODEGENERATION NEUROMELANIN NEUROPATHOLOGY substantia nigra 
Context-dependency in medicine:how neuronal excitability influences the impact of dopamine on cognition
《Neural Regeneration Research》2025年第11期3225-3226,共2页Mahboubeh Ahmadi Nahid Rouhi Javad Mirnajafi-Zadeh Bechara J.Saab 
Dopamine,often termed the"feel-good"neurotransmitter,plays a crucial role in myriad physiological and psychological brain processes.While dopamine is primarily associated with pleasure,reward,and motivation,its effect...
关键词:DOPAMINE EPILEPSY primarily 
How dopamine tunes parvalbumin interneurons in the hippocampus:new experimental observations in Alzheimer's disease
《Neural Regeneration Research》2025年第5期1405-1406,共2页Livia La Barbera Paraskevi Krashia Annalisa Nobili 
supported by an under-40 grant from the Italian Association for Alzheimer’s Research [AIRALZH AGYR2021];the Strategic University Projects–Young Researcher Independence grant [YRG2021] from the Università Campus Bio-Medico di Roma (Rome, Italy)(to LLB);Italian Ministry of Health [Research Grant:GR-2019-12370446];the American Alzheimer’s Association [AARG-22-922961](to PK)。
Despite decades of dedicated resea rch,Alzheimer's disease (AD) is an age-related and progressive neurodegenerative disorder for which the mechanisms of onset are sti unc ear.AD is cha racterized by featured histologi...
关键词:ALZHEIMER alterations DOPAMINE 
Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease
《Neural Regeneration Research》2025年第2期574-586,共13页Olivier Kerdiles Méryl-Farelle Oye Mintsa Mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond Martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon 
supported by funding from Parkinson Canada;funded by a scholarship from Parkinson Canada;a scholarship from Fonds d’Enseignement et de Recherche (FER) (Faculty of Pharmacy, Université Laval)
There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after diagnosis.Given that preclinical and clinical studies suggest benefits of dietary n-3 poly...
关键词:6-HYDROXYDOPAMINE DOPAMINE dopamine transporter EXERCISE neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3 
Dopamine in the prefrontal cortex plays multiple roles in the executive function of patients with Parkinson's disease被引量:2
《Neural Regeneration Research》2024年第8期1759-1767,共9页Zihang Zhou Yalong Yan Heng Gu Ruiao Sun Zihan Liao Ke Xue Chuanxi Tang 
supported by the National Natural Science Foundation of China,No.82101263;Jiangsu Province Science Foundation for Youths,No.BK20210903;Research Foundation for Talented Scholars of Xuzhou Medical University,No.RC20552114(all to CT)。
Parkinson’s disease can affect not only motor functions but also cognitive abilities,leading to cognitive impairment.One common issue in Parkinson’s disease with cognitive dysfunction is the difficulty in executive ...
关键词:DOPAMINE dopamine receptor dopamine transporter executive dysfunction neural network neural oscillation prefrontal cortex synaptic plasticity 
A dysregulated calcium homeostasis as the earliest pathological sign in stem cell-derived Parkinson's disease neurons?
《Neural Regeneration Research》2024年第7期1421-1422,共2页Nilima Prakash 
Parkinson’s disease(PD) is characterized by the slow and progressive demise of dopamine(DA)-synthesizing neurons in the substantia nigra pars compacta(SNc),a nucleus located in the human ventral midbrain.Neuron death...
关键词:HOMEOSTASIS DOPAMINE DEATH 
Hippocampal dopamine as a key regulator for learning deficits in Parkinson's disease被引量:1
《Neural Regeneration Research》2024年第6期1193-1194,共2页Kun Wu Shuai Liu 
supported by the STI 2030-Major Projects,No.2021ZD0200500;the Natural Science Foundation of Shanghai,No.21ZR1419700(both to SL)。
Parkinson's disease(PD)is a progressive neurodegenerative disorder with clinical symptoms of involuntary or uncontrollable movements such as tremors,rigidity,and incoordination.The learning deficit is largely overlook...
关键词:IMPAIRED DOPAMINE CLINICAL 
Cell replacement for Parkinson's disease:advances and challenges被引量:1
《Neural Regeneration Research》2023年第12期2693-2694,共2页Bin Xiao Eng-King Tan 
the Singapore Ministry of Health's National Medical Research Council (Open Fund Large Collaborative Grant (MOH-000207);Singapore Translational Research (STaR) Investigator A word (NMRC/STaR/0030/2018) to EKT,CS-IRG-NIG,OF-YIRG and TA award to BX) for their support。
Parkinson's disease(PD), characterized by the loss of dopaminergic(DA) neurons in the substantia nigra pars compacta(SNpc) of the midbrain, is a prototype neurological disease that is suitable for cellular replacement...
关键词:DOPAMINE CORNERS replace 
Molecular mechanisms underlying the neuroprotection of environmental enrichment in Parkinson’s disease被引量:5
《Neural Regeneration Research》2023年第7期1450-1456,共7页Tamara Andrea Alarcón Sarah Martins Presti-Silva Ana Paula Toniato Simões Fabiola Mara Ribeiro Rita Gomes Wanderley Pires 
Parkinson’s disease is the most common movement disorder,affecting about 1%of the population over the age of 60 years.Parkinson’s disease is characterized clinically by resting tremor,bradykinesia,rigidity and postu...
关键词:ACETYLCHOLINE brain-derived neurotrophic factor DOPAMINE environment enrichment gamma-aminobutyric acid glial cell line-derived neurotrophic factor GLUTAMATE molecular mechanisms Parkinson’s disease 
Blunt dopamine transmission due to decreased GDNF in the PFC evokes cognitive impairment in Parkinson’s disease被引量:2
《Neural Regeneration Research》2023年第5期1107-1117,共11页Chuan-Xi Tang Jing Chen Kai-Quan Shao Ye-Hao Liu Xiao-Yu Zhou Cheng-Cheng Ma Meng-Ting Liu Ming-Yu Shi Piniel Alphayo Kambey Wei Wang Abiola Abdulrahman Ayanlaja Yi-Fang Liu Wei Xu Gang Chen Jiao Wu Xue Li Dian-Shuai Gao 
supported by the National Natural Science Foundation of China,Nos. 81971006 (to DSG), 82101263 (to CXT);Jiangsu Province Science Foundation for Youths,No. BK20210903 (to CXT);Research Foundation for Talented Scholars of Xuzhou Medical University,No. RC20552114 (to CXT);Science&Technology Program of Xuzhou,No. KC19016 (to JC);Project of Xuzhou Medical University,No. 2018KJ06 (to JC)。
Studies have found that the absence of glial cell line-derived neurotrophic factor may be the primary risk factor for Parkinson’s disease. However, there have not been any studies conducted on the potential relations...
关键词:cognitive impairment degree centrality dendritic spine dopamine transmission dopamine transporter glial cell line-derived neurotrophic factor Parkinson’s disease prefrontal cortex synaptic plasticity 
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