supported by the German Research Foundation(grants 514990328,389030878,405358801/428817542(within FOR2879)and 449437943(within TRR332,project C06);German Federal Ministry of Education and Science(3DOS,grant 161L0278B)(to DMH)。
Extracellular vesicles(EVs)are cell-derived,lipid membrane-enclosed vesicles carrying a broad spectrum of biologically active molecules(including proteins,RNAs,and bioactive lipids)which play important roles in interc...
supported by LifeArc Philanthropic Fund(P2019-0004);LifeArc Pathfinder Award;along with Wellcome Trust Seed Award(109626/Z/15/Z);FA PESP-UoB Strategic Collaboration Fund;Birmingham Fellowship(to SS);grants from Laboratoire d'Excellence Revive(Investissement d'Avenir;ANR-10-LABX-73);the Region lle-de-France via doctoral school Innovation Therapeutique,du Fondamentalàl'Appliqué(ED569)from Universite Paris-Saclay(to LA);Medical Research Council(MRC)Developmental Pathway Funding Scheme(DPFS)grant(MR/P007732/1)(to TB);supported by the Association Fran?aise contre les Myopathies(AFM-Téléthon)。
Mitochondria and mitochondria-associated endoplasmic reticulum membrane in neurodegenerative diseases:Mitochondria generate most of the chemical energy needed to power the biochemical reactions of cells,and thus are o...
supported by the Ophthalmological Network OFTARED(RD16/0008/0005),of the Institute of Health of CarlosⅢof the Spanish Ministry of Economy(to AIR,RDH,and JJS);Santander-Complutense University of Madrid Research Projects(PR75/18-21560)(to AIR,RNH,and JJS);supported by a Predoctoral Fellowship(FPU17/01023)from the Spanish Ministry of Science,Innovation,and Universities。
Glaucoma is a neurodegenerative chronic pathology,characterized by the loss of retinal ganglion cells(RGC),which leads to an irreversible vision field loss.The increased intraocular pressure(IOP)constitutes its main r...
supported by the State of South Carolina Spinal Cord Injury Research Fund Board grant No.SCIRF#2017(to MK);the NIH grant No.R21NS114433(to JW and MK);the U.S.Department of Veterans Affairs grant No.RX002090(to IS)。
Asymmetric dimethylarginine(ADMA) and its enantiomer, symmetric dimethylarginine(SDMA), are naturally-occurring methylated metabolites of the L-arginine amino acid moiety of proteins followed by proteolysis(Grosse et ...
supported by the grant of NCBi R(European Union), No.POWR.03.01.00-00-T006/18-00。
Parkinson's disease(PD) is the second most common cause of neurodegeneration.Over the last two decades, various hypotheses have been proposed to explain the etiology of PD.Among these is the oxidant-antioxidant theory...
supported by a grant from the National Research Foundation of Korea, No.NRF-2020R1A2C2007954(to SRK)。
Oxidative stress in Parkinson's disease(PD): Oxidative stress is the imbalance between oxidants, which generate reactive oxygen species(ROS;free radicals), and antioxidants, which remove free radicals.Under healthy co...
Oxidative stress and cyclic adenosine 3′,5′-monophosphate(cAMP)/protein kinase A(PKA)pathway in the optic nerve head astrocytes:Glaucoma is a leading cause of blindness worldwide in individuals 60 years of age and o...
Neurodegenerative diseases and oxidative stress:During the metabolic processes,O2 can accept unpaired electrons to form superoxide radical species(O2^·–),which are able to generate hydrogen peroxide(H2O2)with a fast...
Worldwide stroke is increasing in parallel with modernization,changes in lifestyle,and the growing elderly population.Our review is focused on the link between diet,as part of‘modern lifestyle’,and health in the con...
Ferroptosis is a type of programmed cell death dependent on iron.It is different from other forms of cell death such as apoptosis,classic necrosis and autophagy.Ferroptosis is involved in many neurodegenerative diseas...