RETINOIDS

作品数:29被引量:44H指数:3
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相关领域:医药卫生更多>>
相关作者:郭宗儒王敏敏黄牛潘志红褚凤鸣更多>>
相关机构:中国医学科学院北京协和医学院华中科技大学宜昌市第一人民医院厦门大学更多>>
相关期刊:《Chinese Medical Journal》《World Journal of Diabetes》《Chinese Medical Sciences Journal》《Chinese Journal of Cancer Research》更多>>
相关基金:国家自然科学基金国家重点基础研究发展计划福建省自然科学基金国家杰出青年科学基金更多>>
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Chemoprevention of neuroblastoma: progress and promise beyond uncertainties
《Journal of Cancer Metastasis and Treatment》2023年第1期307-327,共21页Natarajan Aravindan Mohan Natarajan Dinesh Babu Somasundaram Sheeja Aravindan 
Neuroblastoma is the most common extracranial solid tumor in children and comprises one-tenth of all childhood cancer deaths.The current clinical therapy for this deadly disease is multimodal,involving an induction ph...
关键词:NEUROBLASTOMA CHEMOPREVENTION secondary and tertiary chemopreventive phytochemicals RETINOIDS polyphenols TERPENES DFMO apoptosis 
Potential therapeutic roles of retinoids for prevention of neuroinflammation and neurodegeneration in Alzheimer’s disease被引量:13
《Neural Regeneration Research》2019年第11期1880-1892,共13页Bhaskar C. Das Somsankar Dasgupta Swapan K. Ray 
supported in part by an award from the Soy Health Research Program(SHRP,United Soybean Board,Chesterfield,MO,USA)(to SKR);a grant(SCIRF-2015-I-01) from South Carolina Spinal Cord Injury Research Fund(Columbia,SC,USA)(to SKR);earlier R01 grants(CA-091460,and NS-057811)(to SKR) from the National Institutes of Health(Bethesda,MD,USA)
All retinoids, which can be natural and synthetic, are chemically related to vitamin A. Both natural and synthetic retinoids use specific nuclear receptors such as retinoic acid receptors and retinoid X receptors to a...
关键词:Alzheimer's disease AMYLOID PLAQUES neurofibrillary TANGLES NEUROINFLAMMATION NEURODEGENERATION RETINOIDS 
Cancer Chemopreventive Retinoids: Validation and Analysis of in Vivo and in Vitro Bioassay Results
《Journal of Cancer Therapy》2016年第13期1008-1033,共26页John J. Wille Jong Y. Park Y. Fulmer Shealy 
Several natural and synthetic retinoids (vitamin-A derived analogies) were examined for their potential anti-cancer activity in both in vivo animal models and a novel in vitro human keratinocyte clonal growth bioassay...
关键词:Cancer Chemoprevention in Vivo Bioassays in Vitro Bioassays RETINOIDS 
Role of nuclear receptors in breast cancer stem cells被引量:2
《World Journal of Stem Cells》2016年第3期62-72,共11页Alessio Papi Marina Orlandi 
The recapitulation of primary tumour heterogenity and the existence of a minor sub-population of cancer cells,capable of initiating tumour growth in xenografts on serial passages, led to the hypothesis that cancer ste...
关键词:Cancer stem cells HYPOXIA INFLAMMATION Nuclear receptors RETINOIDS Peroxisome proliferator-activator receptors 
Role of retinoids in the prevention and treatment of colorectal cancer被引量:2
《World Journal of Gastrointestinal Oncology》2015年第10期184-203,共20页Catherine C Applegate Michelle A Lane 
Vitamin A and its derivatives, retinoids, have been widely studied for their use as cancer chemotherapeutic agents. With respect to colorectal cancer(CRC), several critical mutations dysregulate pathways implicated in...
关键词:COLORECTAL cancer RETINOID VITAMIN A β-catenin Pho 
Alterations in Retinoic Acid Receptors in Non-Small Cell Lung Cancer and Their Clinical Implications
《Journal of Cancer Therapy》2015年第8期648-664,共17页Sae Muniz-Hernández Norma Hernández-Pedro Omar E.Macedo-Perez Oscar Arrieta 
The nuclear retinoic acid receptor may play a critical role in the process of lung carcinogenesis. Alteration or loss of nuclear retinoic acid receptors (RARs) has been associated with progression in premalignant and ...
关键词:Cell Transformation NEOPLASTIC NEOPLASMS RECEPTORS Retinoic Acid Biological Markers RETINOIDS 
Combination therapies improve the anticancer activities of retinoids in neuroblastoma被引量:2
《World Journal of Clinical Oncology》2015年第6期212-215,共4页Belamy B Cheung 
Most therapeutic protocols for child cancers use cytotoxic agents which have a narrow therapeutic index,and resulting in severe acute and chronic toxicities to normal tissues. Despite the fact that most child cancer p...
关键词:RETINOIDS HISTONE DEACETYLASE inhibitors Combination THERAPIES NEUROBLASTOMA FENRETINIDE 
Metabolic balancing acts of vitamin A in type-2 diabetes and obesity被引量:2
《World Journal of Diabetes》2012年第10期174-177,共4页Rajendra Raghow 
Using mice that lack retinaldehyde dehydrogenase 1 gene(Raldh1-/-mice),Kierfer et al demonstrated that retinoids(metabolites of Vitamin A) play an important role in the regulation of cellular metabolisms and energetic...
关键词:RETINALDEHYDE DEHYDROGENASE 1 VITAMIN A RETINOIDS GLUCONEOGENESIS type 2 DIABETES 
Retinoid and Ethanol-Sensitive Benzo(<i>α</i>)Pyrene Induction of Cytochrome P450 in Human Keratinocytes
《Journal of Cancer Therapy》2012年第6期1080-1085,共6页John J. Wille Jong Y. Park 
Polycyclic aromatic hydrocarbons (PAHs) induce cytochrome P-450 monoxygenase enzymes that catalyze the formation of DNA adducts. We investigated the effects benzo(α)pyrene (B[α]P) alone or in combination with ethano...
关键词:CYP1A1 Aryl Hydrocarbon HYDROXYLASE Benzo(α)Pyrene ETHANOL Keratinocytes RETINOIDS 
Amelioration of glomerulosclerosis with all-trans retinoic acid is linked to decreased plasminogen activator inhibitor-1 and α-smooth muscle actin被引量:3
《Acta Pharmacologica Sinica》2011年第1期70-78,共9页Xia LIU Lei LU Bei-bei TAO Ai-ling ZHOU Yi-chun ZHU 
Acknowledgements This work was supported by grants from the Ministry of Science and Technology of China (No 2010CB912601, 2006CB503804, 2009ZX09303-006, 2009ZX09301-011), the National Natural Science Foundation of China (No 30825016, 30971064), the Science and Technology Commission of Shang- hai Municipality (No 09XD1400400, 08JC1401400) and College Natural Science Research Foundation of Jiangsu Province (No 07KJD310171). We would like to thank Dr Peter ROSE for critical comments regarding this manuscript.
Aim: To examine the effects of all-trans retinoic acid (atRA) on renal morphology and function as well as on renal plasminogen activator inhibitor-1 (PAl-1) expression and plasmin activity in rats with 5/6 nephre...
关键词:NEPHRECTOMY plasminogen activator inhibitor 1 PLASMIN RETINOIDS α-smooth muscle actin 
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