INFLAMMASOME

作品数：391被引量：2615H指数：23
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相关机构：第二军医大学广州医科大学华中科技大学安徽医科大学更多>>
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NLRP3 inflammasome and gut microbiota–brain axis:A new perspective on white matter injury after intracerebral hemorrhage
《Neural Regeneration Research》2026年第1期62-80,共19页Xiaoxi Cai Xinhong Cai Quanhua Xie Xueqi Xiao Tong Li Tian Zhou Haitao Sun 
supported by the Guangdong Basic and Applied Basic Research Foundation,No.2023A1515030045(to HS);Presidential Foundation of Zhujiang Hospital of Southern Medical University,No.yzjj2022ms4(to HS)。
Intracerebral hemorrhage is the most dangerous subtype of stroke,characterized by high mortality and morbidity rates,and frequently leads to significant secondary white matter injury.In recent decades,studies have rev...
关键词：gut microbiota gut microbiota–brain axis immune intracerebral hemorrhage NEUROINFLAMMATION NLRP3 protein stroke THERAPEUTICS white matter injury 
Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss被引量：1
《Neural Regeneration Research》2025年第10期3025-3039,共15页Jia Fang Zhuangzhuang Li Pengjun Wang Xiaoxu Zhang Song Mao Yini Li Dongzhen Yu Xiaoyan Li Yazhi Xing Haibo Shi Shankai Yin 
supported by the National Natural Science Foundation of China,Nos.81800919(to YX),82171140(to PW);the International Cooperation and Exchange of the National Natural Science Foundation of China,Nos.82020108008(to HS),81720108010(to SY).
Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial spectrum.However,their use leads to irreversible hearing damage by causing apoptosis of hair cells as ...
关键词：DEGENERATION hearing loss macrophages Mcc950 neuroinflammation NLRP3 inflammasome OTOTOXICITY pyroptosis sensorineural hearing loss spiral ganglion neuron 
FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression
《Neural Regeneration Research》2025年第7期2068-2083,共16页Jing Yao Yuan Li Xi Liu Wenping Liang Yu Li Liyong Wu Zhe Wang Weihong Song 
supported by a grant from Key Laboratory of Alzheimer's Disease of Zhejiang Province,Institute of Aging,Wenzhou Medical University,No.ZJAD-2021002(to ZW)。
Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in...
关键词：5′end trimming Alzheimer's disease AMYLOID-BETA amyloid-β-dependent transcription FUBP3 INFLAMMASOME inflammation neuron NLRP3 tau transcription factor 
Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder
《Neural Regeneration Research》2025年第6期1541-1554,共14页Jinmei Ye Cong Duan Jiaxin Han Jinrong Chen Ning Sun Yuan Li Tifei Yuan Daihui Peng 
supported by the National Natural Science Foundation of China,No.81971269 (to DP);the Science and Technology Commission of Shanghai,No.YDZX20213100001003 (to DP)。
In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release f...
关键词：BIOMARKER cytokine EXOSOMES INFLAMMASOME major depressive disorder MICROGLIA mitochondrial DNA mitochondrial dysfunction NEUROINFLAMMATION Toll-like receptor 
Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease被引量：1
《Neural Regeneration Research》2025年第6期1644-1664,共21页Gabriela Seplovich Yazan Bouchi Juan Pablo de Rivero Vaccari Jennifer C.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang J.Adrian Tyndall Binu Tharakan Firas Kobeissy 
Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of n...
关键词：Alzheimer's disease caspase-1 chronic traumatic encephalopathy INFLAMMASOMES NEURODEGENERATION neuroinflammation NLRP1 NLRP3 PYROPTOSIS TAUOPATHY traumatic brain injury 
Overexpression of low-density lipoprotein receptor prevents neurotoxic polarization of astrocytes via inhibiting NLRP3 inflammasome activation in experimental ischemic stroke被引量：2
《Neural Regeneration Research》2025年第2期491-502,共12页Shuai Feng Juanji Li Tingting Liu Shiqi Huang Xiangliang Chen Shen Liu Junshan Zhou Hongdong Zhao Ye Hong 
supported by the National Natural Science Foundation of China,No.82201460(to YH);Nanjing Medical University Science and Technology Development Fund,No.NMUB20210202(to YH).
Neurotoxic astrocytes are a promising therapeutic target for the attenuation of cerebral ischemia/reperfusion injury.Low-density lipoprotein receptor,a classic cholesterol regulatory receptor,has been found to inhibit...
关键词：inflammation ischemia/reperfusion injury ischemic stroke low-density lipoprotein receptor neuroprotective astrocytes neurotoxic astrocytes NLRP3 inflammasome POLARIZATION 
NLRP3/1-mediated pyroptosis:beneficial clues for the development of novel therapies for Alzheimer’s disease被引量：5
《Neural Regeneration Research》2024年第11期2400-2410,共11页Bo Hu Jiaping Zhang Jie Huang Bairu Luo Xiansi Zeng Jinjing Jia 
supported by the Natural Science Foundation of Zhejiang Province of China,Nos.LQ22H090003(to JJ),LTGY23C090001(to XZ),LY23H020008(to BH);Sci-Tech Planning Project of Jiaxing,Nos.2021AY30001(to XZ)and 2022AY30020(to JJ).
The inflammasome is a multiprotein complex involved in innate immunity that mediates the inflammatory response leading to pyroptosis,which is a lytic,inflammatory form of cell death.There is accumulating evidence that...
关键词：Alzheimer’s disease caspase-1 GSDMD INFLAMMASOME NEUROINFLAMMATION NLRP1 NLRP3 PYROPTOSIS therapeutic strategies 
3'-Deoxyadenosin alleviates methamphetamine-induced aberrant synaptic plasticity and seeking behavior by inhibiting the NLRP3 inflammasome被引量：1
《Neural Regeneration Research》2024年第10期2270-2280,共11页Yize Qi Yao Zhou Jiyang Li Fangyuan Zhu Gengni Guo Can Wang Man Yu Yijie Wang Tengfei Ma Shanwu Feng Li Zhou 
supported by the National Natural Science Foundation of China,No.81971246 (to TM);Opening Foundation of Jiangsu Key Laboratory of Neurodegeneration,Nanjing Medical University,No.KF202204 (to LZ and SF)。
Methamphetamine addiction is a brain disorder characterized by persistent drug-seeking behavior, which has been linked with aberrant synaptic plasticity. An increasing body of evidence suggests that aberrant synaptic ...
关键词：3′-deoxyadenosin hippocampus long-term potentiation METHAMPHETAMINE NOD-like receptor family pyrin domain containing-3(NLRP3)inflammasome synaptic plasticity 
Microglial NLRP3 inflammasome-mediated neuroinflammation and therapeutic strategies in depression被引量：7
《Neural Regeneration Research》2024年第9期1890-1898,共9页Qiuqin Han Wenhui Li Peiqing Chen Lijuan Wang Xiwen Bao Renyan Huang Guobin Liu Xiaorong Chen 
supported by Health Commission of Pudong New Area Health and Family Planning Scientific Research Project,No.PW2020E-4(to GL);Siming Youth Fund Project of Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,No.SGKJ-202119(to RH);Medical Innovation Research Special Project of 2021“Science and Technology Innovation Action Plan”of Shanghai,No.21Y21920200(to GL);Shanghai Rising-Star Program and Shanghai Sailing Program,No.23YF1418200(to QH);Shanghai Municipal Health Commission Foundation grant,No.20234Y0294(to QH);Hundred Teacher Talent Program of Shanghai University of Medicine and Health Sciences,No.A1-2601-23-311007-21(to QH);the Scientific and Technological Innovation Program of Higher Education Institution in Shanxi,No.2021L350(to XC);the Fundamental Research Program of Shanxi Province,No.20210302124194(to XC).
Previous studies have demonstrated a bidirectional relationship between inflammation and depression.Activation of the nucleotide-binding oligomerization domain,leucine-rich repeat,and NLR family pyrin domain-containin...
关键词：DEPRESSION MICROGLIA NEUROINFLAMMATION NLRP3 inflammasome 
Biochanin A attenuates spinal cord injury in rats during early stages by inhibiting oxidative stress and inflammasome activation被引量：3
《Neural Regeneration Research》2024年第9期2050-2056,共7页Xigong Li Jing Fu Ming Guan Haifei Shi Wenming Pan Xianfeng Lou 
supported by the National Natural Science Foundation of China,Nos.LY20H090018(to XL)and LY20H060008(to HS).
Previous studies have shown that Biochanin A,a flavonoid compound with estrogenic effects,can serve as a neuroprotective agent in the context of cerebral ischemia/reperfusion injury;howeve r,its effect on spinal cord ...
关键词：apoptosis AUTOPHAGY Biochanin A heme oxygenase 1 INFLAMMATION Nrf2 protein nuclear factor kappa-B oxidative stress spinal cord injury Toll-like receptor 4 
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